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Wen-Quan Zhang et al.
Biomedical chromatography : BMC, 29(6), 902-910 (2014-12-18)
Metabonomics based on GC-MS was used to study the possible anti-inflammatory mechanisms of volatile oils of Angelica sinensis (VOAS) in rats with acute inflammation. Acute inflammation was induced by subcutaneous injection of carrageenan in rats. The levels of prostaglandin E2
Seon-Young Han et al.
The Journal of nutrition, 143(5), 632-639 (2013-03-22)
Resveratrol is a phytoalexin abundantly found in red grape skin and is effective in antitumor and antiinflammation associated with immune responses. This study investigated whether resveratrol suppressed immunoglobulin (Ig)E-mediated allergic responses and passive cutaneous anaphylaxis (PCA) in rat RBL-2H3 mast
Yusuke Sakota et al.
Biological & pharmaceutical bulletin, 37(6), 1014-1020 (2014-06-03)
Collagen gel contraction assay is a method for evaluating contraction of cells embedded in collagen gel matrices through measuring the gel size. In the present study, we established a protocol for collagen gel contraction assay using human bronchial smooth muscle
Dominique Laroche et al.
Anesthesiology, 121(2), 272-279 (2014-05-03)
The diagnosis of acute life-threatening allergic reactions during anesthesia relies on clinical signs, histamine and/or tryptase measurements, and allergic testing. In patients who die after the reaction, skin tests cannot be performed, and the effect of resuscitation manoeuvres on mediator
Yasuko Fukushi et al.
Biochemical and biophysical research communications, 447(1), 38-43 (2014-04-01)
Secretion from the gastric gland involves the activation of various types of cells in a coordinated manner. In order to elucidate the mechanisms underlying the coordination of secretion, we studied live fluorescence images of guinea pig gastric glands stained with
Dimitrios A Kyriakidis et al.
Frontiers in bioscience (Landmark edition), 17, 1108-1119 (2011-12-29)
Histamine is a key mediator governing vital cellular processes in mammals beyond its decisive role in inflammation. Recent evidence implies additional actions in both eukaryotes and prokaryotes. Besides its function in host defense against bacterial infections, histamine elicits largely undefined
Q M Zhao et al.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., 58(4), 440-450 (2014-02-13)
In vivo dynamic evaluation of atherosclerosis could be clinically significant in the prevention of cardiovascular events. We aimed to monitor Fluorine-18 fluorodeoxyglucose (18F-FDG) uptake in different stages of atherosclerosis, and investigate the feasibility of detecting vulnerable plaques using positron emission
E C Liao et al.
Journal of investigational allergology & clinical immunology, 23(2), 112-119 (2013-05-10)
Genetically modified organisms (GMOs) provide modern agriculture with improvements in efficiency and the benefits of enhanced food production; however, the potential impact of GMOs on human health has not yet been clarified. To investigate the allergenicity of isopentenyltransferase (ipt)-transformed broccoli
James R F Hockley et al.
Pain, 155(10), 1962-1975 (2014-06-28)
Chronic visceral pain affects millions of individuals worldwide and remains poorly understood, with current therapeutic options constrained by gastrointestinal adverse effects. Visceral pain is strongly associated with inflammation and distension of the gut. Here we report that the voltage-gated sodium
Therese S Salameh et al.
Journal of Alzheimer's disease : JAD, 47(3), 715-728 (2015-09-25)
Intranasal insulin has shown efficacy in patients with Alzheimer's disease (AD), but there are no preclinical studies determining whether or how it reaches the brain. Here, we showed that insulin applied at the level of the cribriform plate via the
Yuko Mitobe et al.
Bioorganic & medicinal chemistry letters, 19(15), 4075-4078 (2009-06-26)
Radioligands are powerful tools for examining the pharmacological profiles of chemical leads and thus facilitate drug discovery. In this study, we identified and characterized 3-([1,1,1-(3)H]methyl)-2-(4-{[3-(1-pyrrolidinyl)propyl]oxy} phenyl)-4(3H)-quinazolinone ([(3)H]1) as a potent and selective radioligand for histamine H(3) receptors. Radioligand [(3)H]1 exhibited
Hannah R Moser et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(14), 6093-6101 (2013-04-05)
Intrathecal application of morphine is among the most powerful methods used to treat severe chronic pain. However, this approach commonly produces itch sufficiently severe that patients are forced to choose between relief of pain or itch. The neuronal populations responsible
Rebecca K Martin et al.
Journal of leukocyte biology, 96(1), 151-159 (2014-03-13)
It has been shown recently that MCs are required for differential regulation of the immune response by granulocytic versus monocytic MDSCs. Granulocytic MDSCs promoted parasite clearance, whereas monocytic MDSCs enhanced tumor progression; both activities were abrogated in MC-deficient mice. Herein
Kenji Abe et al.
Drug and chemical toxicology, 38(2), 167-173 (2014-06-05)
An itch is experientially well known that the scratching response of conditions such as atopic dermatitis is enhanced under psychological stress. Morphine is typical narcotic drug that induces a scratching response upon local application as an adverse drug reaction. Although
Fatemeh Naddafi et al.
American journal of Alzheimer's disease and other dementias, 28(4), 327-336 (2013-05-17)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by beta-amyloid plaques accumulation and cognitive impairment. Both environmental factors and heritable predisposition have a role in AD. Histamine is a biogenic monoamine that plays a role in several physiological functions, including
Xuezhi Bai et al.
Food chemistry, 141(2), 1026-1031 (2013-06-26)
Chunjang and Jajang samples were analysed for biogenic amine contents by using HPLC equipped with a UV-Vis detector. Chunjang samples contained relatively large amounts of histamine (up to 273mg/kg) and tyramine (up to 131mg/kg), whereas Jajang samples had relatively small
Jayati Chakrabarti et al.
NPJ Regenerative medicine, 7(1), 3-3 (2022-01-14)
Sonic Hedgehog (Shh), secreted from gastric parietal cells, contributes to the regeneration of the epithelium. The recruitment of macrophages plays a central role in the regenerative process. The mechanism that regulates macrophage recruitment in response to gastric injury is largely
Vanessa Cousins et al.
Progress in neuro-psychopharmacology & biological psychiatry, 54, 200-205 (2014-06-24)
Tobacco smoking is characterized by repeated self-administration of nicotine by placing the cigarette in the mouth. The repeated hand-to-mouth self-administration is essentially a consummatory act. We recently developed a paradigm in which rats lick one of two spouts to trigger
Martina Sandberg Abelius et al.
Journal of reproductive immunology, 106, 100-109 (2014-07-23)
The immunological milieu in the placenta may be crucial for priming the developing foetal immune system. Early imbalances may promote the establishment of immune-mediated diseases in later life, including allergies. The initial exposure to allergens seems to occur in utero
P J Turner et al.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 25(7), 657-661 (2014-10-10)
Most children with egg allergy tolerate egg in baked foods, such as cake, but tolerance cannot be predicted with conventional allergy testing. We hypothesized that the skin prick test (SPT) wheal to unprocessed raw egg might predict tolerance of baked
Yvonne Hagenlocher et al.
Molecular immunology, 63(1), 25-31 (2014-02-15)
In the past decades an increasing prevalence of allergic disorders was observed in industrialized countries. Thus, it is necessary to develop adequate therapeutic and preventive strategies. Many of the conservative strategies possess diverse harmful side effects. Therefore agents with fewer
Mu A et al.
Nature cell biology, 21(5), 592-602 (2019-04-10)
Inverted formin 2 (INF2) is a member of the formin family of actin assembly factors. Dominant missense mutations in INF2 are linked to two diseases: focal segmental glomerulosclerosis, a kidney disease, and Charcot-Marie-Tooth disease, a neuropathy. All of the disease
Fuat Bicer et al.
American journal of physiology. Renal physiology, 308(2), F103-F113 (2014-09-12)
The cause of chronic pelvic pain in interstitial cystitis/painful bladder syndrome (IC/PBS) remains unclear; autoimmunity is a possible etiology. We have recently shown that injection of a single immunogenic peptide of uroplakin 3A (UPK3A 65-84) induces experimental autoimmune cystitis (EAC)
Ahmed Lazrak et al.
American journal of physiology. Lung cellular and molecular physiology, 308(9), L891-L903 (2015-03-10)
Chlorine (Cl2) inhalation induces severe oxidative lung injury and airway hyperresponsiveness (AHR) that lead to asthmalike symptoms. When inhaled, Cl2 reacts with epithelial lining fluid, forming by-products that damage hyaluronan, a constituent of the extracellular matrix, causing the release of
Maja Johansson et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(5), G400-G409 (2015-07-04)
Hepatic encephalopathy (HE) is one of the primary complications of liver cirrhosis. Current treatments for HE, mainly directed to reduction of ammonia levels, are not effective enough because they cannot completely eliminate hyperammonemia and inflammation, which induce the neurological alterations.
David Acton et al.
Cell reports, 28(3), 625-639 (2019-07-18)
Acute itch can be generated by either chemical or mechanical stimuli, which activate separate pathways in the periphery and spinal cord. While substantial progress has been made in mapping the transmission pathway for chemical itch, the central pathway for mechanical
Rong-Rong Zhai et al.
Virology, 442(2), 163-172 (2013-05-09)
Altered cytokine profiles and imbalanced frequencies of CD4(+) T helper cell subsets are thought to be linked with HIV-1/AIDS pathogenesis, but the causes need to be further clarified. Histamine, a biogenic amine with many functions, shows enhancement in HIV-1 infected
Alexander F Hagel et al.
Naunyn-Schmiedeberg's archives of pharmacology, 386(9), 789-793 (2013-05-15)
Histamine plays an important role in the development of symptoms in allergic, infectious, neoplastic and other diseases. Empirical findings have suggested beneficial effects of ascorbic acid supplementation in those diseases, and these effects are assumed to be related to a
Giannina Descalzi et al.
Journal of neurochemistry, 126(5), 636-650 (2013-06-22)
Recent investigations into the mechanisms mediating itch transmission have focused on spinal mechanisms, whereas few studies have investigated the role of the cerebral cortex in itch-related behaviors. Human imaging studies show that several cortical regions are active in correspondence with
Kenji Maeda et al.
The Journal of pharmacology and experimental therapeutics, 350(3), 589-604 (2014-06-21)
Brexpiprazole (OPC-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one) is a novel drug candidate in clinical development for psychiatric disorders with high affinity for serotonin, dopamine, and noradrenaline receptors. In particular, it bound with high affinity (Ki < 1 nM) to human serotonin 1A (h5-HT1A)-, h5-HT2A-
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