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M4530

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Se-Hyuk Kim et al.
Hepatology (Baltimore, Md.), 63(1), 247-259 (2015-10-13)
Hepatocyte chromosome polyploidization is an important feature of liver development and seems to be required for response to liver stress and injury signals. However, the question of how polyploidization can be tightly regulated in liver growth remains to be answered....
David M Barry et al.
Nature communications, 10(1), 5705-5705 (2019-12-15)
Although kidney parenchymal tissue can be generated in vitro, reconstructing the complex vasculature of the kidney remains a daunting task. The molecular pathways that specify and sustain functional, phenotypic and structural heterogeneity of the kidney vasculature are unknown. Here, we...
Lei Luo et al.
Frontiers in cell and developmental biology, 9, 604232-604232 (2021-03-12)
SIN3A is the central scaffold protein of the SIN3/histone deacetylase (HDAC) transcriptional repressor complex. SIN3A participates in the mouse preimplantation development by fine-tuning HDAC1 expression. However, it remains unresolved if this functional significance of SIN3A was conserved in other mammals....
Olatunji A Akerele et al.
Reproduction (Cambridge, England), 154(2), 153-165 (2017-06-01)
There is clear evidence that nutritional strategy employed during pregnancy has profound influence on the offspring health outcomes. However, the effect of the quality and the quantity of maternal fat intake on maternal metabolic profile during different stages of pregnancy...
V van Duinen et al.
Scientific reports, 7(1), 18071-18071 (2017-12-24)
Current in vitro models to test the barrier function of vasculature are based on flat, two-dimensional monolayers. These monolayers do not have the tubular morphology of vasculature found in vivo and lack important environmental cues from the cellular microenvironment, such...
E Canon et al.
Reproduction (Cambridge, England), 156(2), 145-161 (2018-06-06)
The POU5F1 gene encodes one of the 'core' transcription factors necessary to establish and maintain pluripotency in mammals. Its function depends on its precise level of expression, so its transcription has to be tightly regulated. To date, few conserved functional...
Joshua R St Clair et al.
American journal of physiology. Heart and circulatory physiology, 309(3), H490-H498 (2015-05-24)
Pacemaker myocytes in the sinoatrial node of the heart initiate each heartbeat by firing spontaneous action potentials. However, the molecular processes that underlie pacemaking are incompletely understood, in part because of our limited ability to manipulate protein expression within the...
Sebastian Steven et al.
Redox biology, 13, 370-385 (2017-07-02)
Hyperglycemia associated with inflammation and oxidative stress is a major cause of vascular dysfunction and cardiovascular disease in diabetes. Recent data reports that a selective sodium-glucose co-transporter 2 inhibitor (SGLT2i), empagliflozin (Jardiance®), ameliorates glucotoxicity via excretion of excess glucose in...
Patrick C Baer et al.
International journal of molecular sciences, 21(2) (2020-01-16)
Gliflozins are inhibitors of the renal proximal tubular sodium-glucose co-transporter-2 (SGLT-2), that inhibit reabsorption of urinary glucose and they are able to reduce hyperglycemia in patients with type 2 diabetes. A renoprotective function of gliflozins has been proven in diabetic...
Yun Fei Diao et al.
PloS one, 9(6), e100205-e100205 (2014-06-14)
Histone H3 lysine 36 (H3K36) methylation is known to be associated with transcriptionally active genes, and is considered a genomic marker of active loci. To investigate the changes in H3K36 methylation in pig, we determined the mono-, di-, and tri-methylations...
Pawel Kordowitzki et al.
Aging, 12(8), 7576-7584 (2020-04-28)
Maternal aging-associated reduction of oocyte viability is a common feature in mammals, but more research is needed to counteract this process. In women, the first aging phenotype appears with a decline in reproductive function, and the follicle number gradually decreases...
S K Kavoussi et al.
Molecular human reproduction, 15(10), 687-692 (2009-08-01)
The aim of this study was to investigate whether peroxisome proliferator-activated receptor (PPAR)-gamma activation has an effect on the attachment of endometrial cells to peritoneal mesothelial cells in a well-established in vitro model of the early endometriotic lesion. The endometrial...
C Ling et al.
Diabetologia, 51(4), 615-622 (2008-02-14)
Insulin secretion in pancreatic islets is dependent upon mitochondrial function and production of ATP. The transcriptional coactivator peroxisome proliferator activated receptor gamma coactivator-1 alpha (protein PGC-1alpha; gene PPARGC1A) is a master regulator of mitochondrial genes and its expression is decreased...
Mahdi Heidari et al.
Animal reproduction science, 205, 62-69 (2019-04-22)
The aims of the present study were to determine the concentrations of lipopolysaccharide (LPS), hormonal progesterone, estradiol-17β, insulin growth factor (IGF-1) and magnesium in the serum and the preovulatory follicle follicular fluid (FF) in repeat breeder (RB) cows without (nSCE)...
Claudia Rehwald et al.
British journal of cancer, 122(3), 421-433 (2019-11-28)
We aimed at clarifying the role of lipocalin-2 (LCN-2) in clear-cell renal cell carcinoma (ccRCC). Since LCN-2 was recently identified as a novel iron transporter, we explored its iron load as a decisive factor in conferring its biological function. LCN-2...
Sanghoon Lee et al.
International journal of molecular sciences, 22(5) (2021-04-04)
The purpose of this study is to investigate the effectiveness of sphingosine-1-phosphate (S1P) and Z-VAD-FMK (Z-VAD) as anti-apoptotic agents to preserve ovarian function and prevent tissue damage during ovarian tissue cryopreservation and transplantation. This study consisted of two steps, in...
Vincent W W van Eif et al.
Development (Cambridge, England), 146(8) (2019-04-03)
The rate of contraction of the heart relies on proper development and function of the sinoatrial node, which consists of a small heterogeneous cell population, including Tbx3+ pacemaker cells. Here, we have isolated and characterized the Tbx3+ cells from Tbx3+/Venus...
Muath Q Al-Ghadi et al.
Saudi journal of biological sciences, 27(9), 2280-2286 (2020-09-05)
Although, it has been success in the generation of animal clones from somatic cells in various animal species, the information related to nuclear reprogramming of cloned embryos is found to be limited. This study aims to compares the effect of...
Sanghoon Lee et al.
International journal of molecular sciences, 20(13) (2019-07-11)
Two methods for the cryopreservation of human ovarian tissue were compared using a xenotransplantation model to establish a safe and effective cryopreservation method. Ovarian tissues were obtained from women who underwent benign ovarian surgery in the gynecology research unit of...
A Moretti et al.
Nature medicine, 26(2), 207-214 (2020-01-29)
Frameshift mutations in the DMD gene, encoding dystrophin, cause Duchenne muscular dystrophy (DMD), leading to terminal muscle and heart failure in patients. Somatic gene editing by sequence-specific nucleases offers new options for restoring the DMD reading frame, resulting in expression...
Immacolata Castellano et al.
Oxidative medicine and cellular longevity, 2018, 2087373-2087373 (2018-06-01)
Chronic hyperglycemia is associated with oxidative stress and vascular inflammation, both leading to endothelial dysfunction and cardiovascular disease that can be weakened by antioxidant/anti-inflammatory molecules in both healthy and diabetic subjects. Among natural molecules, ovothiol A, produced in sea urchin...
Fu Liang Ng et al.
Human molecular genetics, 26(5), 989-1002 (2017-01-15)
Genome-wide association studies have revealed an association between variation at the SLC4A7 locus and blood pressure. SLC4A7 encodes the electroneutral Na+/HCO3- co-transporter NBCn1 which regulates intracellular pH (pHi). We conducted a functional study of variants at this locus in primary...
Amanda Fanous et al.
Plastic and reconstructive surgery, 143(3), 760-767 (2019-01-03)
Keloid scarring is a serious condition that mostly affects patients of African or Asian descent. Often disfiguring, this condition can have devastating psychosocial consequences. To date, no treatment modality has been proven ideal. The authors' objectives were (1) to determine...
Jorgelina Manes et al.
Theriogenology, 85(5), 856-861 (2015-12-03)
The use of intravaginal sponges (IS) to synchronize estrous onset in ewes provokes vaginitis, an increase in the vaginal bacterial load, and growth of bacterial species that are not present during spontaneous estrous behavior. The objective of the study was...
Melanie Wirkner et al.
Chembiochem : a European journal of chemical biology, 12(17), 2623-2629 (2011-11-08)
We report the synthesis and properties of a photoactivatable caged RGD peptide and its application for phototriggering integrin- and cell-binding to surfaces. We analysed in detail 1) the differences in the integrin-binding affinity of the caged and uncaged forms by...
Christian Zierhut et al.
Cell, 178(2), 302-315 (2019-07-13)
Pathogenic and other cytoplasmic DNAs activate the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway to induce inflammation via transcriptional activation by IRF3 and nuclear factor κB (NF-κB), but the functional consequences of exposing cGAS to chromosomes upon mitotic nuclear...
Kai Wang et al.
PloS one, 6(7), e22197-e22197 (2011-07-30)
Global activation of the embryonic genome (EGA), one of the most critical steps in early mammalian embryo development, is recognized as the time when interspecies somatic cell nuclear transfer (iSCNT) embryos fail to thrive. In this study, we analyzed the...
Chaitra Rao et al.
eLife, 10 (2021-05-11)
The epithelial-to-mesenchymal transition (EMT) is considered a transcriptional process that induces a switch in cells from a polarized state to a migratory phenotype. Here, we show that KSR1 and ERK promote EMT-like phenotype through the preferential translation of Epithelial-Stromal Interaction...
Venkata Ramana Vaka et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 316(5), R441-R447 (2019-02-28)
Preeclampsia (PE) is characterized by new-onset hypertension during pregnancy and is associated with immune activation and placental oxidative stress. Mitochondrial dysfunction is a major source of oxidative stress and may play a role in the pathology of PE. We (Vaka...
Katharina Ehrenhöfer-Wölfer et al.
Scientific reports, 9(1), 11661-11661 (2019-08-14)
SMARCA4/BRG1 and SMARCA2/BRM, the two mutually exclusive catalytic subunits of the BAF complex, display a well-established synthetic lethal relationship in SMARCA4-deficient cancers. Using CRISPR-Cas9 screening, we identify SMARCA4 as a novel dependency in SMARCA2-deficient esophageal squamous cell carcinoma (ESCC) models...
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