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PHG0007

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Eleri Hughes et al.
PloS one, 9(9), e106746-e106746 (2014-09-17)
Phospholamban (PLB) is a pentameric protein that plays an important role in regulating cardiac contractility via a reversible inhibitory association with the sarcoplasmic reticulum Ca2+ATPase (SERCA), the enzyme responsible for maintaining correct calcium homeostasis. Here we study the functional and...
Jiping Zhao et al.
Inflammation, 38(4), 1464-1472 (2015-02-07)
The aim of our study was to elucidate the function and signaling pathway of found in inflammatory zone 1 (FIZZ1) in airway remodeling in asthma. We used a mice model sensitized and challenged by ovalbumin (OVA) to evaluate the expression...
M B Camarada et al.
Physical chemistry chemical physics : PCCP, 17(29), 19001-19011 (2015-07-02)
Cationic dendrimers, such as PAMAM, are known to be positively charged at neutral pH allowing their unspecific interaction with proteins and other cellular components. Especially, ferritin, which has an important role in iron homeostasis, presents a negative electrostatic potential at...
Rajendra Prasad et al.
Nucleic acids research, 42(10), 6337-6351 (2014-04-29)
Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme in mammalian cells. The enzyme synthesizes polymers of ADP-ribose from the coenzyme NAD(+) and plays multifaceted roles in cellular responses to genotoxic stress, including DNA repair. It had been shown that mouse...
C Arimany-Nardi et al.
British journal of pharmacology, 171(16), 3868-3880 (2014-05-02)
Inhibitors of DNA methyltransferases (DNMTs), such as azacytidine, decitabine and zebularine, are used for the epigenetic treatment of cancer. Their action may depend upon their translocation across the plasma membrane. The aim of this study was to identify transporter proteins...
Zhifeng Dong et al.
International journal of cardiology, 179, 397-408 (2014-12-03)
Clinically, approximately one-third of patients with chronic heart failure (CHF) exhibit some degree of renal dysfunction. This renal dysfunction is referred to as cardiorenal syndrome (CRS) and plays an important role in the poor prognosis of CHF. Mounting evidence suggests...
Zhiping Jiang et al.
Journal of molecular biology, 426(24), 4074-4086 (2014-12-03)
Pmel17 is an important protein for pigmentation in human skin and eyes. Proteolytic fragments from Pmel17 form fibrils upon which melanin is deposited in melanosomes. The repeat domain (RPT) derived from Pmel17 only forms fibrils under acidic melanosomal conditions. Here...
Seock Hwan Choi et al.
Journal of biomedical materials research. Part A, 103(4), 1391-1403 (2014-07-22)
Acellular scaffolds, possessing an intact three-dimensional extracellular matrix (ECM) architecture and biochemical components, are promising for regeneration of complex organs, such as the kidney. We have successfully developed a porcine renal acellular scaffold and analyzed its physical/biochemical characteristics, biocompatibility, and...
Junghui Koo et al.
The Journal of biological chemistry, 290(22), 14120-14129 (2015-04-22)
Rictor, an essential component of mTOR complex 2 (mTORC2), plays a pivotal role in regulating mTOR signaling and other biological functions. Posttranslational regulation of rictor (e.g. via degradation) and its underlying mechanism are largely undefined and thus are the focus...
Arturo Luna-Tapia et al.
Antimicrobial agents and chemotherapy, 59(4), 2410-2420 (2015-02-11)
The azole antifungals block ergosterol biosynthesis by inhibiting lanosterol demethylase (Erg11p). The resulting depletion of cellular ergosterol and the accumulation of "toxic" sterol intermediates are both thought to compromise plasma membrane function. However, the effects of ergosterol depletion upon the...
P Massoner et al.
British journal of cancer, 111(5), 955-964 (2014-07-06)
Expression of epithelial cell adhesion molecule (EpCAM) is deregulated in epithelial malignancies. Beside its role in cell adhesion, EpCAM acts as signalling molecule with tumour-promoting functions. Thus, EpCAM is part of the molecular network of oncogenic receptors and considered an...
Patricia L Bustos et al.
Parasitology, 142(8), 1024-1032 (2015-04-01)
Cyclosporin A (CsA) specifically inhibits the mitochondrial permeability transition pore (mPTP). Opening of the mPTP, which is triggered by high levels of matrix [Ca2+] and/or oxidative stress, leads to mitochondrial dysfunction and thus to cell death by either apoptosis or...
Hikmet Nural-Guvener et al.
International journal of molecular sciences, 16(5), 11482-11499 (2015-05-23)
Recent studies have linked histone deacetylases (HDAC) to remodeling of the heart and cardiac fibrosis in heart failure. However, the molecular mechanisms linking chromatin remodeling events with observed anti-fibrotic effects are unknown. Here, we investigated the molecular players involved in...
Tara L Croston et al.
American journal of physiology. Heart and circulatory physiology, 307(1), H54-H65 (2014-04-30)
The mitochondrion has been implicated in the development of diabetic cardiomyopathy. Examination of cardiac mitochondria is complicated by the existence of spatially distinct subpopulations including subsarcolemmal (SSM) and interfibrillar (IFM). Dysfunction to cardiac SSM has been reported in murine models...
Nan Zhang et al.
BMC genomics, 16, 685-685 (2015-09-09)
Bacillus amyloliquefaciens SQR9 is a plant growth-promoting rhizobacteria (PGPR) with outstanding abilities to enhance plant growth and to control soil-borne diseases. Root exudates is known to play important roles in plant-microbe interactions. To explore the rhizosphere interactions and plant-beneficial characteristics...
Tomoaki Harada et al.
Physical chemistry chemical physics : PCCP, 16(28), 14947-14952 (2014-06-17)
Luminescent europium (Eu) and dysprosium (Dy) doped yttrium-vanadate (Y-V) nanoparticles (NPs) were synthesized in the cavity of the protein, apoferritin. Y-V NPs were synthesized by incubating a solution of apoferritin with Y(3+) and VO3(-) ions in the presence of ethylene...
Kailash P Patra et al.
Infection and immunity, 83(5), 1799-1808 (2015-02-19)
A vaccine to prevent the transmission of malaria parasites from infected humans to mosquitoes is an important component for the elimination of malaria in the 21st century, yet it remains neglected as a priority of malaria vaccine development. The lead...
Fabio Fuselli et al.
Journal of the science of food and agriculture, 95(13), 2757-2762 (2014-11-27)
Prevention of food fraud in the dairy field is a difficult issue for researchers, industries and policy makers, both for commercial and health reasons. Currently, no analytical method allows detection of the addition of bovine whey to water buffalo ricotta...
Malik M Keshwani et al.
The Biochemical journal, 466(2), 311-322 (2014-12-23)
The alternative splicing of human genes is dependent on SR proteins, a family of essential splicing factors whose name derives from a signature C-terminal domain rich in arginine-serine dipeptide repeats (RS domains). Although the SRPKs (SR-specific protein kinases) phosphorylate these...
Frédéric Lamoth et al.
Journal of clinical microbiology, 53(10), 3176-3181 (2015-07-24)
Invasive mold infections are life-threatening diseases for which appropriate antifungal therapy is crucial. Their epidemiology is evolving, with the emergence of triazole-resistant Aspergillus spp. and multidrug-resistant non-Aspergillus molds. Despite the lack of interpretive criteria, antifungal susceptibility testing of molds may...
Shota Tanaka et al.
Biological & pharmaceutical bulletin, 38(3), 435-440 (2015-03-12)
Epithelial-mesenchymal transition (EMT) and changes in the expression of the microRNA-200 (miR-200) family were examined in the human colorectal cancer (CRC) cell line SW620 with acquired oxaliplatin (L-OHP) resistance. Two CRC cell lines, SW480, derived from primary CRC, and SW620...
Shunsuke Izaki et al.
Journal of pharmaceutical sciences, 104(6), 1929-1937 (2015-03-27)
Development of high-concentration antibody formulations for subcutaneous administration remains challenging. Recently, a precipitation-redissolution method was proposed to prepare suspensions or precipitates of salt-dissociable protein-poly(amino acid) complexes. To elucidate the utility of this method for protein therapy, we investigated the feasibility...
Nripendra Nath Mishra et al.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 18(3), 287-293 (2014-01-07)
Candida albicans utilizes arachidonic acid (AA) released during the course of infection (Candidiasis) from phospholipids of infected host cell membranes and synthesizes extracellular prostaglandin(s) which play an important role in hyphae formation and host cell damage. C. albicans biofilms secrete...
Karolin Zerulla et al.
PloS one, 9(4), e94819-e94819 (2014-04-16)
Haloferax volcanii uses extracellular DNA as a source for carbon, nitrogen, and phosphorous. However, it can also grow to a limited extend in the absence of added phosphorous, indicating that it contains an intracellular phosphate storage molecule. As Hfx. volcanii...
Marta Luna-Sánchez et al.
EMBO molecular medicine, 7(5), 670-687 (2015-03-25)
Primary coenzyme Q10 (CoQ10) deficiency is due to mutations in genes involved in CoQ biosynthesis. The disease has been associated with five major phenotypes, but a genotype-phenotype correlation is unclear. Here, we compare two mouse models with a genetic modification...
Dominique E Williams et al.
Chembiochem : a European journal of chemical biology, 16(10), 1474-1482 (2015-05-09)
With the goal of designing a lysosomal phospholipase mimic, we optimized experimental variables to enhance Ce(IV) -assisted hydrolysis of phosphatidylcholine (PC) liposomes. Our best result was obtained with the chelating agent bis-tris propane (BTP). Similar to the hydrolytic enzyme, Ce(IV)...
Mineaki Kitamura et al.
Biological & pharmaceutical bulletin, 38(2), 193-200 (2015-03-10)
Long-term peritoneal dialysis therapy causes inflammation and histological changes in the peritoneal membrane. Inflammation generally activates fibroblasts and results in fibroblast-myofibroblast differentiation. Heat-shock protein 47 (HSP 47), a collagen-specific molecular chaperone, is localized in myofibroblasts and is involved in the...
Chloe Kim et al.
Nanoscale, 7(42), 17820-17826 (2015-10-13)
Current diagnostic methods for traumatic brain injury (TBI), which accounts for 15% of all emergency room visits, are limited to neuroimaging modalities. The challenges of accurate diagnosis and monitoring of TBI have created the need for a simple and sensitive...
Sandy G Y Szeto et al.
Experimental cell research, 330(2), 248-266 (2014-12-03)
In cell culture, many adherent mammalian cells undergo substantial actin cytoskeleton rearrangement prior to mitosis as they detach from the extracellular matrix and become spherical. At the end of mitosis, the actin cytoskeleton is required for cytokinesis and the reassembly...
Frederik De Bruyn et al.
Biotechnology and bioengineering, 112(8), 1594-1603 (2015-03-03)
Glycosylation of small molecules can significantly alter their properties such as solubility, stability, and/or bioactivity, making glycosides attractive and highly demanded compounds. Consequently, many biotechnological glycosylation approaches have been developed, with enzymatic synthesis and whole-cell biocatalysis as the most prominent...
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