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t3258
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Elena N Kozlova et al.
Cell transplantation, 21(12), 2537-2554 (2012-04-04)
Transplantation of stem or progenitor cells is an attractive strategy for cell replacement therapy. However, poor long-term survival and insufficiently reproducible differentiation to functionally appropriate cells in vivo still present major obstacles for translation of this methodology to clinical applications.
Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
Mark D Gurden et al.
Cancer research, 75(16), 3340-3354 (2015-07-24)
Acquired resistance to therapy is perhaps the greatest challenge to effective clinical management of cancer. With several inhibitors of the mitotic checkpoint kinase MPS1 in preclinical development, we sought to investigate how resistance against these inhibitors may arise so that
Susanne Muehlich et al.
Molecular and cellular biology, 28(20), 6302-6313 (2008-08-13)
Megakaryoblastic leukemia 1 (MKL1) is a myocardin-related coactivator of the serum response factor (SRF) transcription factor, which has an integral role in differentiation, migration, and proliferation. Serum induces RhoA-dependent translocation of MKL1 from the cytoplasm to the nucleus and also
Kirsten Holthusen et al.
Journal of virology, 89(14), 7277-7290 (2015-05-08)
Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) induces constitutive signaling in EBV-infected cells to ensure the survival of the latently infected cells. LMP1 is localized to lipid raft domains to induce signaling. In the present study, a genome-wide
Jian Lv et al.
Bioorganic & medicinal chemistry letters, 17(15), 4102-4106 (2007-06-16)
Several representative amphiphilic cationic quinine-derived have been synthesized and evaluated against methicillin- resistant Staphylococcus aureus. This is the first reported antibacterial activity of this class of compounds. In vitro the minimal inhibitory concentration values of the best compound Q7 ranged
Larisa Volceanov et al.
mBio, 5(5), e01802-e01814 (2014-10-09)
Chlamydia trachomatis is an obligate intracellular human pathogen that grows inside a membranous, cytosolic vacuole termed an inclusion. Septins are a group of 13 GTP-binding proteins that assemble into oligomeric complexes and that can form higher-order filaments. We report here
Smita Joel et al.
ACS chemical biology, 9(7), 1595-1602 (2014-05-21)
Advancements in biotechnology have allowed for the preparation of designer proteins with a wide spectrum of unprecedented chemical and physical properties. A variety of chemical and genetic methods can be employed to tailor the protein's properties, including its stability and
Nicole Wolter et al.
Antimicrobial agents and chemotherapy, 51(3), 1092-1095 (2007-01-11)
A rare clinical isolate of Streptococcus pneumoniae, highly resistant to telithromycin, contained erm(B) with a truncated leader peptide and a mutant ribosomal protein L4. By transformation of susceptible strains, this study shows that high-level telithromycin resistance is conferred by erm(B)
Bhaskar S Dawane et al.
European journal of medicinal chemistry, 45(1), 387-392 (2009-11-10)
Several 1-(4-(4'-chlorophenyl)-2-thiazolyl)-3-aryl-5-(2-butyl-4-chloro-1H-imidazol-5yl)-2-pyrazoline derivatives were prepared by the base catalyzed treatment of appropriate chalcones with 4-(4'-chlorophenyl)-2-hydrazino-thiazole in poly (ethylene glycol) (PEG-400) as an alternative reaction solvent. All the synthesized compounds were tested for their antimicrobial activities against Escherichia coli (MTCC 2939)
Babasaheb P Bandgar et al.
Bioorganic & medicinal chemistry, 17(24), 8168-8173 (2009-11-10)
A novel series of 1-(2,4-dimethoxy-phenyl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)-propenone (3) have been prepared by the Claisen-Schmidt condensation of 1-(2,4-dimethoxy-phenyl)-ethanone (1) and substituted 1,3-diphenyl-1H-pyrazole-4-carbaldehydes (2). Substituted 1,3-diphenyl-1H-pyrazole-4-carbaldehydes (2) were prepared by Vilsmeir-Haack reaction on acetophenonephenylhydrazones to offer the target compounds. The structures of the compounds
Stefanie Heller et al.
Antimicrobial agents and chemotherapy, 51(6), 1956-1961 (2007-03-28)
BAL19403 exemplifies a new family of macrolide antibiotics with excellent in vitro activity against propionibacteria. MICs indicated that BAL19403 was very active against erythromycin-resistant and clindamycin-resistant propionibacteria with mutations in the region from positions 2057 to 2059 (Escherichia coli numbering)
Maurice Ducret Awouafack et al.
Journal of natural products, 74(2), 272-278 (2011-01-27)
Two new isopropenyl-dihydrofuranoisoflavones exhibiting antimicrobial properties have been isolated along with eight known compounds from the Cameroonian medicinal plant Crotalaria lachnophora. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and high-resolution mass spectrometry as
V Plasencia et al.
Antimicrobial agents and chemotherapy, 51(7), 2574-2581 (2007-05-02)
We studied the mechanisms and dynamics of the development of resistance to ceftazidime (CAZ) alone or combined with tobramycin (TOB) or ciprofloxacin (CIP) in vitro and in vivo (using a mouse model of lung infection with human antibiotic regimens). Pseudomonas
C L Ward et al.
Cell death & disease, 5, e1572-e1572 (2014-12-17)
Fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is a multifunctional RNA/DNA-binding protein that is pathologically associated with cancer and neurodegeneration. To gain insight into the vital functions of FUS and how a loss of FUS function impacts cellular homeostasis
Increased risk of acute pancreatitis among tetracycline users in a Swedish population-based case-control study
Rickard Ljung, Jesper Lagergren, et al.
Gut, 10.1136, 300949-300949 (2011)
Robert Bucki et al.
Antimicrobial agents and chemotherapy, 54(6), 2525-2533 (2010-03-24)
The rising number of antibiotic-resistant bacterial strains represents an emerging health problem that has motivated efforts to develop new antibacterial agents. Endogenous cationic antibacterial peptides (CAPs) that are produced in tissues exposed to the external environment are one model for
Lourdes Santana et al.
Journal of medicinal chemistry, 51(21), 6740-6751 (2008-10-07)
The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives
Ronald N Jones et al.
Diagnostic microbiology and infectious disease, 75(4), 402-405 (2013-03-22)
Tetracycline class agents vary widely in their activity against emerging important antimicrobial-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter spp. Also, published susceptibility breakpoints are discordant between the Clinical and Laboratory Standards Institute (CLSI), the European Committee on
Guntis Cepurnieks et al.
Journal of pharmaceutical and biomedical analysis, 102, 184-192 (2014-10-06)
A new multi-class method has been developed for the identification and quantification of the residues of 26 antibiotics from different classes (sulfonamides, macrolides, tetracyclines, penicillins, and quinolones) in milk and meat by ultra performance liquid chromatography coupled to hybrid quadrupole
Yan-Qiang Huang et al.
World journal of gastroenterology, 21(14), 4225-4231 (2015-04-22)
To investigate the inhibitory effects of emodin, baicalin, etc. on the hefA gene of multidrug resistance (MDR) in Helicobacter pylori (H. pylori). The double dilution method was used to screen MDR H. pylori strains and determine the minimum inhibitory concentrations
Jun Okuda et al.
Antimicrobial agents and chemotherapy, 54(11), 4917-4919 (2010-09-02)
A mini-Tn5 insertion into a ciprofloxacin (CIP)-resistant mutant of Vibrio cholerae O1 revealed that overexpression of the vca0421 gene, which encodes a hypothetical protein, in the CIP-resistant mutant carrying a mutation in the quinolone resistance-determining region (QRDR) of the gyrA
Melissa Stemig et al.
PloS one, 10(4), e0123843-e0123843 (2015-04-16)
Molecular regulators of osteoclast formation and function are an important area of research due to the central role of osteoclasts in bone resorption. Transcription factors such as MITF are essential for osteoclast generation by regulating expression of the genes required
Christoph D Mayer et al.
European journal of medicinal chemistry, 46(8), 3227-3236 (2011-05-17)
A series of steroid and azasteroid analogues containing a six-membered ring A with various functionalities were synthesized. Furthermore, the syntheses of tetracyclic analogues bearing a five-membered A-ring and the syntheses of a number of bicyclic secosteroid analogues were carried out.
Nuno M Oliveira et al.
PLoS biology, 13(7), e1002191-e1002191 (2015-07-15)
Bacteria form dense surface-associated communities known as biofilms that are central to their persistence and how they affect us. Biofilm formation is commonly viewed as a cooperative enterprise, where strains and species work together for a common goal. Here we
Thithiwat May et al.
Antimicrobial agents and chemotherapy, 53(11), 4628-4639 (2009-09-02)
Biofilms gain resistance to various antimicrobial agents, and the presence of antibiotic resistance genes is thought to contribute to a biofilm-mediated antibiotic resistance. Here we showed the interplay between the tetracycline resistance efflux pump TetA(C) and the ampicillin resistance gene
Qing Xie et al.
Biomaterials, 66, 67-82 (2015-07-22)
Mesenchymal stem cells (MSCs) have been extensively applied in the field of tissue regeneration. MSCs derived from various tissues exhibit different characteristics. In this study, a cluster of cells were isolated from human ethmoid sinus mucosa membrane and termed as
Alireza Nezamzadeh-Ejhieh et al.
Chemosphere, 107, 136-144 (2014-05-31)
Photodegradation of tetracycline (TC) aqueous solution by FeO doped onto nano-clinoptilolite particles was investigated using a high pressure Hg lamp as radiation source. Nano-particles of clinoptilolite were prepared using ball-milling of micro crystals of zeolite. The pretreated nano-particles ion exchanged
Imran Nafees Siddiqui et al.
Journal of natural products, 74(3), 365-373 (2011-01-20)
Chemical investigation of the fungal strain Microdiplodia sp. isolated from the shrub Lycium intricatum led to the isolation of four new compounds: a hexahydroxanthone (2), a 2,3-dihydrochroman-4-one (3), a 7-oxoxanthone derivative (4), and a 1,4-oxazepan-7-one (5). The relative configurations of
B L M de Jonge et al.
Antimicrobial agents and chemotherapy, 53(8), 3331-3336 (2009-05-13)
Pyrazolopyrimidinediones are a novel series of compounds that inhibit growth of Helicobacter pylori specifically. Using a variety of methods, advanced analogues were shown to suppress the growth of H. pylori through the inhibition of glutamate racemase, an essential enzyme in
Stuart Ainsworth et al.
Applied and environmental microbiology, 80(14), 4341-4349 (2014-05-13)
Lactococcus lactis subsp. cremoris strains are used globally for the production of fermented dairy products, particularly hard cheeses. Believed to be of plant origin, L. lactis strains that are used as starter cultures have undergone extensive adaptation to the dairy
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