ABAT
4-aminobutyrate aminotransferase
Synonymes:
GABA-AT, GABAT, NPD009
Espèce(s):
Human ABAT (18), Mouse Abat (268860), Rat Abat (81632), Horse ABAT (100051470), cow ABAT (280969), sheep ABAT (101105462), Goat ABAT (100861058), domestic guinea pig Abat (100725419), domestic cat ABAT (101089064), naked mole-rat Abat (101712584) ...Plus
ID UniProtKB:
ID du gène:
- Human(18) Summary: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(268860) 4-aminobutyrate aminotransferase
- Rat(81632) 4-aminobutyrate aminotransferase
- Horse(100051470) 4-aminobutyrate aminotransferase
- cow(280969) 4-aminobutyrate aminotransferase
- sheep(101105462) 4-aminobutyrate aminotransferase
- Goat(100861058) 4-aminobutyrate aminotransferase
- domestic guinea pig(100725419) 4-aminobutyrate aminotransferase
- domestic cat(101089064) 4-aminobutyrate aminotransferase
- naked mole-rat(101712584) 4-aminobutyrate aminotransferase
- chicken(416642) 4-aminobutyrate aminotransferase
- Zebrafish(378968) 4-aminobutyrate aminotransferase
- dog(479856) 4-aminobutyrate aminotransferase
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Antibodies
Numéro du produit
Description
Espèces réactives
Application
Anti-ABAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Anti-ABAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Anti-ABAT antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
bovine, dog, goat, guinea pig, human, mouse, rabbit, rat
Application
western blot
Anti-GABA transaminase (ABAT) Antibody, clone 10V1K9, Rabbit Monoclonal, ,
Espèces réactives
human, rat
Application
immunohistochemistry
western blot
western blot
Small Molecule - Inhibitor
Numéro du produit
Description
Espèce(s)
Vigabatrin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human