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CHRM2

cholinergic receptor, muscarinic 2

Synonymes:
HM2
Espèce(s):
Human CHRM2 (1129), Mouse Chrm2 (243764), Rat Chrm2 (81645), Domestic Rabbit CHRM2 (100342878), naked mole-rat Chrm2 (101714286), chicken CHRM2 (418126), domestic guinea pig Chrm2 (100715343), dog CHRM2 (403858), cow CHRM2 (522170), domestic cat CHRM2 (101099790) ...Plus
ID UniProtKB:
P08172, Q4VBK6, Q9P1X9
ID du gène:
  • Human(1129) Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(243764) cholinergic receptor, muscarinic 2, cardiac
  • Rat(81645) cholinergic receptor, muscarinic 2
  • Domestic Rabbit(100342878) cholinergic receptor, muscarinic 2
  • naked mole-rat(101714286) cholinergic receptor, muscarinic 2
  • chicken(418126) cholinergic receptor, muscarinic 2
  • domestic guinea pig(100715343) cholinergic receptor, muscarinic 2
  • dog(403858) cholinergic receptor, muscarinic 2
  • cow(522170) cholinergic receptor, muscarinic 2
  • domestic cat(101099790) cholinergic receptor, muscarinic 2
  • sheep(101102897) cholinergic receptor, muscarinic 2
  • sheep(100628317) cholinergic receptor, muscarinic 2

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Small Molecule - Agonist

Numéro du produit
Description
Espèce(s)
P6503
Pilocarpine hydrochloride, ≥99% (titration), powder,
Espèce(s)
human
A2251
Acetyl-β-methylcholine chloride, ≥98% (TLC), powder,
Espèce(s)
human
P6628
Pilocarpine nitrate salt, ≥98% (HPLC),
Espèce(s)
human
O100
Oxotremorine M, solid,
Espèce(s)
human
M104
(±)-Muscarine chloride hydrate, ≥98% (HPLC),
Espèce(s)
human

Small Molecule - Antagonist

Numéro du produit
Description
Espèce(s)
M105
Methoctramine hydrate, ≥97% (NMR), solid,
Espèce(s)
human
SML1102
Darifenacin hydrobromide, ≥98% (HPLC),
Espèce(s)
human
1485103
Oxybutynin chloride, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
O0288000
Oxybutynin hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
1164200
Darifenacin hydrobromide, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human

Antibodies

Numéro du produit
Description
Espèces réactives
Application
MAB367
Anti-Muscarinic Acetylcholine Receptor m2 Antibody, clone M2-2-B3, clone M2-2-B3, Chemicon®, from rat,
Espèces réactives
human, mammals, monkey, rat
Application
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
AB9452
Anti-Muscarinic Acetylcholine Receptor M2 Antibody, Chemicon®, from rabbit,
Espèces réactives
human
Application
immunohistochemistry
WH0001129M1
Monoclonal Anti-CHRM2 antibody produced in mouse, clone 4B5, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
western blot
SAB5702535
Anti-Muscarinic AChR M2 (ACM2) Antibody, clone 3T5W8, Rabbit Monoclonal, ,
Espèces réactives
human, rat
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Numéro du produit
Description
Espèce(s)
A8404
Amitriptyline hydrochloride, ≥98% (TLC), powder,
Espèce(s)
human
D4526
Doxepin hydrochloride, ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder,
Espèce(s)
human
H1512
Haloperidol, powder,
Espèce(s)
human, rat

Small Molecule - Ligand

Numéro du produit
Description
Espèce(s)
A138
Aminobenztropine, solid,
Espèce(s)
human

Proteins

Numéro du produit
Description
Espèce(s)
HTS115M
ChemiSCREEN Membrane Preparation Recombinant Human M2 Muscarinic Acetylcholine Receptor, Human M2 GPCR membrane prepation for Radioligand binding Assays.,
Espèce(s)
human

esiRNA

Numéro du produit
Description
Espèce(s)
EHU120771
MISSION® esiRNA, targeting human CHRM2,
Espèce(s)
human