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ACHE

acetylcholinesterase

Synonyme:
ACEE, ARACHE, N-ACHE, YT
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(43) Summary: Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]
  • Mouse(11423) acetylcholinesterase
  • Rat(83817) acetylcholinesterase
  • domestic guinea pig(100422792) acetylcholinesterase
  • sheep(101123006) acetylcholinesterase
  • cow(540446) acetylcholinesterase
  • domestic cat(493674) acetylcholinesterase
  • Zebrafish(114549) acetylcholinesterase
  • chicken(396388) acetylcholinesterase
  • naked mole-rat(101705724) acetylcholinesterase
  • dog(489828) acetylcholinesterase

Custom & Knockdown Gene Products

Small Molecule - Activator

Produktnummer
Beschreibung
Spezies
Pyridin-2-Aldoxim-Methochlorid, ,
Spezies
human
Pralidoximchlorid, United States Pharmacopeia (USP) Reference Standard,
Spezies
human

Small Molecule - Agonist

Produktnummer
Beschreibung
Spezies
Acetylthiocholinchlorid, ≥99% (TLC), powder,
Spezies
human

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-Acetylcholinesterase Antibody, clone AE-1, clone AE-1, Chemicon®, from mouse,
Speziesreaktivität
bovine, canine, chicken, guinea pig, human, monkey
Anwendung
ELISA
immunohistochemistry

immunoprecipitation (IP)
Anti-Acetylcholinesterase (AChE) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
immunofluorescence
western blot
Anti-ACHE antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Speziesreaktivität
cat, human, mouse, rabbit, rat
Anwendung
ELISA
flow cytometry

immunofluorescence

western blot
Anti-ACHE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Speziesreaktivität
human
Anwendung
immunofluorescence
Anti-ACHE antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, rat
Anwendung
western blot

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
Donepezil hydrochloride, ≥98% (HPLC),
Spezies
human
Scopoletin, ≥99%,
Spezies
human
Pyridostigminbromid, ,
Spezies
human
Neostigminbromid, ≥98% (HPLC and titration), powder,
Spezies
human
Galanthamine hydrobromide from Lycoris sp., ≥94% (HPLC),
Spezies
human

Kits

Produktnummer
Beschreibung
Spezies
Acetylcholinesterase Activity Assay Kit, sufficient for 100 colorimetric tests,
Spezies
mouse, human

Proteins

Produktnummer
Beschreibung
Spezies
Acetylcholinesterase human, recombinant, expressed in HEK 293 cells, lyophilized powder, ≥1,000 units/mg protein (BCA),
Spezies
human
Acetylcholinesterase aus Humanerythrocyten, buffered aqueous solution, ≥500 units/mg protein (BCA),
Spezies
human

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting human ACHE,
Spezies
human