HPLC Analysis of Aripiprazole and Dehydro Aripiprazole Using a Titan C18 Column
Materialien
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CONDITIONS
column
Titan C18, 10 cm x 3.0 mm I.D., 1.9 μm particles (577160-U)
mobile phase
[A] 10 mM ammonium formate; pH 3.0 with formic acid [B] 0.1% formic acid in methanol
gradient
40% B for 0.5 minutes followed by a linear gradient to 95% B for 3.5 minutes, followed by a hold at 95% B for 2 minutes.
flow rate
0.5 mL/min
pressure
6500 psi (445 bar)
column temp.
35 °C
detector
UV, 245 nm
injection
2 μL
sample
50 μg/mL in 10% methanol
Beschreibung
Hinweis zur Analyse
Aripiprazole is marketed as the atypical antipsychotic Abilify® for the treatment of schizophrenia, bipolar disorder and clinical depression. Dehydroapiprazole is the primary metabolite of Aripiprazole.
Rechtliche Hinweise
Abilify is a registered trademark of Otsuka Pharmaceutical Co.
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