HomeWebinarsSulfonyl Fluorides in Chemical Biology and Drug Discovery

Sulfonyl Fluorides in Chemical Biology and Drug Discovery


Sulfonyl fluorides are privileged protein-reactive functional groups due to their context-specific reactivity with a broad range of amino acid residues (tyrosine, serine, lysine, threonine, cysteine, and histidine). As a result, they are ideally suited to a myriad of applications in chemical biology and drug discovery. To highlight the growing utility of sulfonyl fluoride chemical probes, examples will be provided from the literature and work in which Dr. Jones has been involved.

What Will You Learn?

Topics to be discussed include

  • Sulfonyl fluorides as biocompatible, protein-reactive groups
  • Covalent modification of amino acid residues in a context-specific manner
  • Synthetic chemistry compatible with the sulfonyl fluoride functionality
  • Current applications of sulfonyl fluoride probes – utility in drug discovery
  • Predicting amino acid reactivity
  • Future prospects for sulfonyl fluoride chemical biology – expanding the toolbox


Dr. Lyn Jones


Head of Rare Diseases Chemistry, Chemical Biology

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