Hexadimethrine bromide

≥94% (titration)

Polybrene, 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide
CAS Number:
MDL number:

Quality Level


≥94% (titration)

storage temp.




InChI key


Looking for similar products? Visit Product Comparison Guide

General description

Hexadimethrine bromide is a quaternary ammonium compound which works as a heparin antagonist. It is also involved in the transformation of low molecular weight DNA.


Hexadimethrine bromide can be used to transfect mammalian cells with DNA. It can be used to increase the efficiency of lipofection transfections.
Hexadimethrine bromide has been used for lentivirus infection in cells. It has been used for infection of cells with retroviral supernatant.


5, 10, 50, 100 g in poly bottle


Exclamation mark





Acute Tox. 4 Oral


11 - Combustible Solids

WGK Germany


Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. Is Product H9268, Hexadimethrine bromide, the same thing as Polybrene?

    Yes, Polybrene (registered trade-mark of Abbott) and 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide, are Synonyms. 

  3. What is the molecular weight of Product H9268, Hexadimethrine bromide?

    According to the information from our supplier, the molecular weight of this product is 4,000-6,000.The chemicals encyclopedia published by the Royal Society of Chemistry provides a general MW range for the chemical of 5,000 - 10,000.

  4. What is the solubility of Product H9268, Hexadimethrine bromide?

    Soluble in water up to 10%.

  5. How do I sterilize Product H9268, Hexadimethrine bromide?

    Hexadimethrine bromide can be filtered sterilized or autoclaved.

  6. What is the solution stability of Product H9268, Hexadimethrine bromide?

    Stock solutions in 0.9% saline solution at 1 mg/mL are stable at least one year stored in the refrigerator.  Stability information is found on the Product Bulletin.

  7. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  8. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  9. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Redei GP
Encyclopedia of Genetics, Genomics, Proteomics, and Informatics (2008)
E2F1 modulates p38 MAPK phosphorylation via transcriptional regulation of ASK1 and Wip1.
Hershko T
The Journal of Biological Chemistry, 281, 31309-31309 (2006)
An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo.
Fang C et al.
Cardiovascular Research, 99, 146-146 (2013)
Molecular pathways regulating pro-migratory effects of Hedgehog signaling.
Hochman E et al.
The Journal of Biological Chemistry, 281, 33860-33860 (2006)
Gaetana Restivo et al.
Nature communications, 8(1), 1988-1988 (2017-12-08)
Cutaneous melanoma represents the most fatal skin cancer due to its high metastatic capacity. According to the "phenotype switching" model, the aggressive nature of melanoma cells results from their intrinsic potential to dynamically switch from a high-proliferative/low-invasive to a low-proliferative/high-invasive...
The introduction of small interfering RNAs (siRNAs) into cultured cells provides a fast and efficient means of knocking down gene expression and has allowed siRNAs to quickly become a ubiquitous tool in molecular biology.
Read More
Introduction of small interfering RNAs (siRNAs) into cultured cells provides a fast and efficient means of knocking down gene expression and has allowed siRNAs to quickly become a ubiquitous tool in molecular biology.
Read More
Our lentiviral vector systems are developed with enhanced safety features. Numerous precautions are in place in the design of our lentiviruses to prevent replication. Good handling practices are a must.
Read More
Successful targeting relies on optimizing key sensitive steps in the process, including lentiviral transduction. Below are some helpful handling and titration tips from our R&D lentiviral experts.
Read More
You are not alone designing successful CRISPR, RNAi, and ORF experiments. Sigma-Aldrich was the first company to commercially offer lentivirus versions of targeted genome modification technologies and has the expertise and commitment to support new generations of scientists.
Read More
FACS (Fluorescence-Activated Cell Sorting) provides a method for sorting a mixed population of cells into two or more groups, one cell at a time, based on the specific light scattering and fluorescence of each cell. This method provides fast, objective, and quantitative recording of fluorescent signals from individual cells.
Read More

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service