240850

Sigma-Aldrich

D-Sorbitol

99%

Synonym(s):
D-Glucitol
Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
Molecular Weight:
182.17
Beilstein/REAXYS Number:
1721899
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

vapor density

<1 (vs air)

Quality Level

vapor pressure

<0.1 mmHg ( 25 °C)

assay

99%

form

powder

optical activity

[α]20/D +104°, c = 0.4 in acidified ammonium molybdate

mp

98-100 °C (lit.)

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-JGWLITMVSA-N

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Application

May be used for washing spheroplasts and in isoelectric focusing to minimize endoosmotic flow in agarose gels. May be used to induce osmotic stress.
Sorbitol, a bacterial culture supplement, has been used for the preparation of selective plating media to culture Sorbitol-fermenting bacteria including strains of Escherichia coli and Yersinia enterocolitica. It has also been used as one of the ingredients to prepare Drosophila embryos for immunoelectron microscopy. It has also been used as an additive to glucuronoxylan as potential food packaging material.

Packaging

5, 100 g in poly bottle

Biochem/physiol Actions

D-Sorbitol is a sugar alcohol that is commonly used as a sugar substitute. It occurs naturally and is also produced synthetically from glucose. The food industry uses D-sorbitol as an additive in the form of a sweetener, humectant, emulsifier, thickener, or dietary supplement. D-Sorbitol has also been found in cosmetics, paper, and pharmaceuticals. Naturally, D-sorbitol occurs widely in plants via photosynthesis, ranging from algae to higher order fruits of the family Rosaceae.
Sorbitol is a slowly metabolized sugar alcohol produced by reduction of glucose. In the polyol pathway, sorbitol is further oxidized to fructose by sorbitol dehydrogenase. Sorbitol does not diffuse easily across the cell membranes and may cause osmotic damage to the cells. The metabolism of sorbitol is most important in the pathology of diabetes related vascular complications.

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Maria Gröndahl et al.
Biomacromolecules, 5(4), 1528-1535 (2004-07-13)
Free films based on glucuronoxylan isolated from aspen wood were prepared by casting from aqueous solutions and drying in a controlled environment. Addition of xylitol or sorbitol facilitated film formation and thus examination of the material properties of these films....
J Jeffery et al.
Proceedings of the National Academy of Sciences of the United States of America, 80(4), 901-905 (1983-02-01)
A pathway from glucose via sorbitol bypasses the control points of hexokinase and phosphofructokinase in glucose metabolism. It also may produce glycerol, linking the bypass to lipid synthesis. Utilization of this bypass is favored by a plentiful supply of glucose--hence...
M Brownlee
Nature, 414(6865), 813-820 (2001-12-14)
Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All...
Shiliang Zhang et al.
Methods in molecular biology (Clifton, N.J.), 475, 275-297 (2008-11-04)
Myoblast fusion in Drosophila has become a powerful genetic system with which to unravel the mechanisms underlying cell fusion. The identification of important components of myoblast fusion by genetic analysis has led to a molecular pathway toward our understanding of...
Preparation of extracts from yeast.
S M Jazwinski
Methods in enzymology, 182, 154-174 (1990-01-01)

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