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Hydrogen chloride

ReagentPlus®, ≥99%

Linear Formula:
CAS Number:
Molecular Weight:
MDL number:
PubChem Substance ID:

Quality Level

vapor density

1.3 (vs air)

vapor pressure

613 psi ( 21.1 °C)

product line







−85 °C (lit.)


−114 °C (lit.)


1.2 g/mL at 25 °C (lit.)

SMILES string




InChI key


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General description

Hydrogen chloride (HCl) exists in gaseous form under normal conditions. It can be used either in the gaseous or solution form. HCl is generally used in the synthesis of organic, inorganic compounds, salt formation, pH control, neutralizations and surface cleaning.


HCl can be used:
  • As a catalyst in the synthesis of β-amino ketone in presence of H2O-SDS system by Mannich reaction.
  • In the synthesis of polymer-layered silicate nanocomposites.


227 g in steel cylinder

Other Notes

For 295426-230G-EU packaging: 1000 mL of steel cylinder equipped with stainless steel valve.
For 295426-227G steel cylinder with ASB valve.(See recommended products)

Recommended products

  • For 295426-227G: Z148504/Z148512 CGA 180 Regulators, OR Z146978 CGA 110 Valve, and Z146986 washer for valve. Also recommended Z562629 CGA 180 Lecture Bottle Station.
  • For 295426-230G-EU: outlet fitting: DIN 477-1 no.1, Z742162 or Z742164 are the recommended regulators.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Signal Word


Hazard Statements

Hazard Classifications

Acute Tox. 3 Inhalation - Eye Dam. 1 - Press. Gas Compr. Gas - Skin Corr. 1A

Storage Class Code

2A - Gases



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What type of cylinder does the Product 295426, Hydrogen Chloride, come in?

    The Hydrogen Chloride is packaged in a lecture bottle.  The cylinder will be about one foot in length and about two inches in diameter.  For 295426-227G, the valve on the cylinder has a CGA 180M / 110F fitting on it, while DIN 477-1 fittings are found on 295426-230-EU.  The cylinder mass is approximately 1023g (empty) and the valve mass is approximately 206g, giving a total approximate mass of 1229g.  The cylinders are DOT rated (rating is stamped on cylinder).

  4. What is the pressure of the cylinder containing Product 295426, Hydrogen Chloride?

    Approximately 600psi.

  5. Can empty lecture bottles be returned?

    Yes, empty lecture bottles can be returned using one of two methods.  You can either call Technical Service at 1-800-231-8327 or send an email to to have a Lecture Bottle Return Packet sent to you.  The packet will include terms and conditions for returning the cylinder(s) and fees.  Cylinders cannot yet be returned in Europe.  Please note:  Cylinders must be empty to be accepted.

  6. What equipment is needed to use the Hydrogen Chloride cylinder for Product 295426?

    Since Hydrogen Chloride is a corrosive gas, only Stainless Steel or Monel equipment should be used.  For 295426-227G, Monel control valve Z146978 or Monel gas regulators Z406058, Z406066 are recommended.  We would also recommend a Cross Purge Assembly, Z562483 be used in conjunction with the regulators.  A Stainless Steel Hose Barb Adapter Z146838 may also be needed depending on the setup being used.  For 295426-230-EU, regulators Z742162 or Z742164 are recommended.

  7. Is there a deposit for the cylinder containing Product 295426, Hydrogen Chloride,?

    No, we do not require a deposit for lecture bottle cylinders.  However, you can return the lecture bottles. 

  8. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  9. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Corrosion inhibition of mild steel by plant extract in dilute HCl medium
Chauhan LR and Gunasekaran G
Corrosion Science, 49(3), 1143-1161 (2007)
HCl-catalyzed stereoselective Mannich reaction in H2O-SDS system
Akiyama T, et al.
Synlett, 2005(02) (2005)
Polymer-layered silicate nanocomposites: preparation, properties and uses of a new class of materials
Alexandre M and Dubois P
Materials Science & Engineering. R, Reports : A Review Journal, 28(1-2), 1-63 (2000)
Confused HCl: hydrogen chloride or hydrochloric acid?
Perumalla, SR and Sun CC
Chemistry?A European Journal , 18(21), 6462-6464 (2012)
Charlotte Strandgren et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3193-3205 (2015-04-17)
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder that is most commonly caused by a de novo point mutation in exon 11 of the LMNA gene, c.1824C>T, which results in an increased production of a truncated form of

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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