1.37028

SAFC

Glycerol

anhydrous (vegetable), EMPROVE® EXPERT, Ph. Eur., BP, JP, USP, ACS reagent

Synonym(s):
1,2,3-Propanetriol, Trihydroxylpropane, Protol, Glycerin, 1,2,3-Propanetriol, Glycerin
Linear Formula:
HOCH2CH(OH)CH2OH
CAS Number:
Molecular Weight:
92.09
Beilstein/REAXYS Number:
635685
MDL number:
EC Index Number:
200-289-5

storage conditions

Store at +5°C to +30°C.

Quality Level

grade

ACS reagent

Agency/Method

BP
JP
Ph. Eur.
USP

vapor density

3.1 (vs air)

vapor pressure

<1 mmHg ( 20 °C)

product line

EMPROVE® EXPERT

assay

≤98.0-101.0% (calculated on anhydrous substance, alkalimetric)
≥99.5% (calculated on anhydrous substance, GC)

form

liquid

autoignition temp.

698 °F

potency

12600 mg/kg LD50, oral (Rat)
>18700 mg/kg LD50, skin (Rabbit)

expl. lim.

2.6-11.3 % (v/v)

application(s)

electrophoresis: suitable

refractive index

n20/D 1.474 (lit.)

pH

5 (20 °C, 100 g/L in H2O)

bp

182 °C/20 mmHg (lit.)

mp

20 °C (lit.)

transition temp

flash point 199 °C

density

1.25 g/mL (lit.)

storage temp.

2-30°C

SMILES string

OCC(O)CO

InChI

1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2

InChI key

PEDCQBHIVMGVHV-UHFFFAOYSA-N

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General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Glycerol can be used in a wide variety of solid, semi-solid and liquid formulations, including ophthalmic, oral solid and oral liquid dosages, tablet coatings, creams and gels. It is applied for its humectant, emollient, solvent/cosolvent, viscosity increasing, and plasticizer properties.
Glycerol anhydrous (vegetable) Emprove® Expert is low in endotoxins and bioburden, making it the right choice for your high-risk applications.
Glycerol is used both in sample preparation and gel formation for polyacrylamide gel electrophoresis. Glycerol (5-10%) increases the density of a sample so that the sample will layer at the bottom of a gel′s sample well. Glycerol is also used to aid in casting gradient gels and as a protein stabilizer and storage buffer component.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

storage_class_code

10 - Combustible liquids

WGK Germany

WGK 1

Flash Point F

390.2 °F - Pensky-Martens closed cup

Flash Point C

199 °C - Pensky-Martens closed cup

Certificate of Analysis

Certificate of Origin

What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials.

Material Qualification Dossier

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Operational Excellence Dossier

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