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73594

Supelco

Ammonium acetate

LiChropur, eluent additive for LC-MS

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Linear Formula:
CH3CO2NH4
CAS Number:
Molecular Weight:
77.08
Beilstein:
4186741
EC Number:
MDL number:
eCl@ss:
39021908
PubChem Substance ID:
NACRES:
NB.21

grade

eluent additive for LC-MS

Quality Level

Assay

≥99.0% (calc. on dry substance, T)

form

solid

quality

LiChropur

technique(s)

LC/MS: suitable

impurities

insoluble matter, passes filter test
≤1% water

ign. residue

≤0.01% (as SO4)

pH

6.2-7.5 (25 °C, 1 M in H2O)

mp

110-112 °C (dec.) (lit.)

solubility

H2O: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤5 mg/kg
nitrate (NO3-): ≤10 mg/kg
sulfate (SO42-): ≤10 mg/kg

cation traces

Al: ≤1 mg/kg
As: ≤0.1 mg/kg
Ba: ≤1 mg/kg
Bi: ≤1 mg/kg
Ca: ≤5 mg/kg
Cd: ≤1 mg/kg
Co: ≤1 mg/kg
Cr: ≤1 mg/kg
Cu: ≤1 mg/kg
Fe: ≤1 mg/kg
K: ≤5 mg/kg
Li: ≤1 mg/kg
Mg: ≤1 mg/kg
Mn: ≤1 mg/kg
Mo: ≤1 mg/kg
Na: ≤5 mg/kg
Ni: ≤1 mg/kg
Pb: ≤1 mg/kg
Sr: ≤1 mg/kg
Zn: ≤1 mg/kg

λ

1 M in H2O

UV absorption

λ: 260 nm Amax: ≤0.015
λ: 280 nm Amax: ≤0.010

suitability

passes test for LC-MS

SMILES string

N.CC(O)=O

InChI

1S/C2H4O2.H3N/c1-2(3)4;/h1H3,(H,3,4);1H3

InChI key

USFZMSVCRYTOJT-UHFFFAOYSA-N

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This Item
37233132301238074
Ammonium acetate LiChropur™, eluent additive for LC-MS

Supelco

73594

Ammonium acetate

-
Ammonium acetate 99.999% trace metals basis

Sigma-Aldrich

372331

Ammonium acetate

-
Ammonium acetate puriss. p.a., ACS reagent, reag. Ph. Eur., ≥98%

Sigma-Aldrich

32301

Ammonium acetate

Essential Grade
Ammonium acetate ACS reagent, ≥97%

Sigma-Aldrich

238074

Ammonium acetate

-
assay

≥99.0% (calc. on dry substance, T)

assay

99.999% trace metals basis

assay

≥98%

assay

≥97%

form

solid

form

crystalline, solid

form

solid

form

powder, solid

impurities

insoluble matter, passes filter test, ≤1% water

impurities

≤20.0 ppm Trace Metal Analysis

impurities

≤0.005% KMnO4 red. matter (as O), ≤2% water (Karl Fischer), ≤5 mg/kg heavy metals (as Pb)

impurities

≤0.005% insolubles

pH

6.2-7.5 (25 °C, 1 M in H2O)

pH

-

pH

6.7-7.3 (25 °C, 5% in water)

pH

6.7-7.3 (25 °C, 5%)

mp

110-112 °C (dec.) (lit.)

mp

110-112 °C (dec.) (lit.)

mp

110-112 °C (dec.) (lit.)

mp

110-112 °C (dec.) (lit.)

General description

Ammonium acetate exists as a white crystal. It is prepared from acetic acid and ammonia by neutralization to pH 7.0. It is widely used in analytical chemistry, drugs and in textile dyeing.

Application

Ammonium acetate has been used to prepare eluents for UPLC-MS/MS and HPLC-MS/MS to compare the matrix effect of 9 pharmaceutical compounds in aqueous environmental samples. It has also been used as an additive to improve detection of phosphopeptides using MALDI-MS.

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Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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25G
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705578-5MG-PW

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MMYOMAG-74K-13

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Formic acid 98% - 100% for LC-MS LiChropur™

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Formic acid 98% - 100%

Ammonium acetate ACS reagent, ≥97%

Sigma-Aldrich

238074

Ammonium acetate

Comparison of matrix effects in HPLC-MS/MS and UPLC-MS/MS analysis of nine basic pharmaceuticals in surface waters.
Van De Steene JC, Lambert WE.
Journal of the American Society For Mass Spectrometry, 19(5), 713-718 (2008)
Dale L. Perry
Handbook of Inorganic Compounds, 17-17 (1995)
Enhanced detection of phosphopeptides in matrix-assisted laser desorption/ionization mass spectrometry using ammonium salts.
Asara JM, Allison J.
Journal of the American Society For Mass Spectrometry, 10(1), 35-44 (1999)
J M Asara et al.
Journal of the American Society for Mass Spectrometry, 10(1), 35-44 (1999-01-15)
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) has been used successfully to detect phosphorylation sites in proteins. Applications may be limited by the low response of phosphopeptides compared to nonphosphorylated peptides in MALDI MS. The addition of ammonium salts to
Jet C Van De Steene et al.
Journal of the American Society for Mass Spectrometry, 19(5), 713-718 (2008-03-18)
When developing an LC-MS/MS-method matrix effects are a major issue. The effect of co-eluting compounds arising from the matrix can result in signal enhancement or suppression. During method development much attention should be paid to diminishing matrix effects as much

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