Demethoxycurcumin

Name: Demethoxycurcumin
Brand: SIAL
Price: 296 CHF
Availability: InStock

analytical standard

Synonym(s):

(E,E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione, Curcumin II, Desmethoxycurcumin, Monodemethoxycurcumin

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10 MG

CHF 296.00

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₈O₅

CAS Number:

22608-11-3

Molecular Weight:

338.35

MDL number:

MFCD03427310

UNSPSC Code:

85151701

PubChem Substance ID:

329769932

NACRES:

NA.24

Key Documents

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grade

analytical standard

Quality Level

100

Assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

SMILES string

COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)cc2)ccc1O

InChI

1S/C20H18O5/c1-25-20-12-15(6-11-19(20)24)5-10-18(23)13-17(22)9-4-14-2-7-16(21)8-3-14/h2-12,21,24H,13H2,1H3/b9-4+,10-5+

InChI key

HJTVQHVGMGKONQ-LUZURFALSA-N

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Analytical Chemistry

Analytical Chromatography

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Show Differences

1 of 4

This Item	90594	69727	50202
Supelco 90593 Demethoxycurcumin	Supelco 90594 Bisdemethoxycurcumin	Supelco 69727 Hexahydrocurcumin	Supelco 50202 Tetrahydrocurcumin
application(s) food and beverages	application(s) food and beverages	application(s) food and beverages	application(s) food and beverages
technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable
format neat	format neat	format neat	format neat
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
grade analytical standard	grade analytical standard	grade analytical standard	grade analytical standard
assay ≥95.0% (HPLC)	assay ≥95.0% (HPLC)	assay ≥90.0% (HPLC)	assay ≥95.0% (HPLC)

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

This compound is commonly found in plants of the genus: curcuma

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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The inhibitory effect of turmeric curcuminoids on matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells.

Mathanaporn Boonrao et al.

Archives of pharmacal research, 33(7), 989-998 (2010-07-28)

Matrix metalloproteinase-3 (MMP-3) is a key enzyme with important implications in the invasion and metastasis of breast cancer cells. Curcumin (Cur), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) are major forms of curcuminoids found in turmeric powder with reported anticancer activity. This

The inhibitory effects of different curcuminoids on β-amyloid protein, β-amyloid precursor protein and β-site amyloid precursor protein cleaving enzyme 1 in swAPP HEK293 cells.

Hongying Liu et al.

Neuroscience letters, 485(2), 83-88 (2010-08-24)

The hallmark of Alzheimer's disease (AD) is the accumulation of β-amyloid protein (Aβ). Aβ is generated from the β-amyloid precursor protein (APP) through the proteolysis of β-site APP cleaving enzyme 1 (BACE1) and γ-secretase. Aβ(42) isoform is more easily aggregate

Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-kappaB signaling pathways in N9 microglia induced by lipopolysaccharide.

Lijia Zhang et al.

International immunopharmacology, 10(3), 331-338 (2009-12-19)

Our previous report has showed that demethoxycurcumin (DMC), a natural derivative of curcumin (Cur), exhibited stronger inhibitory activity on nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) production compared with Cur in lipopolysaccharide (LPS) activated rat primary microglia. In the

Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line.

Supachai Yodkeeree et al.

European journal of pharmacology, 627(1-3), 8-15 (2009-10-13)

Demethoxycurcumin (DMC) is one of the main active compounds of curcuminoids found in turmeric powder, which is used as a spice in Asian cooking and traditional medicine. Recent studies reveal that DMC has several biological activities including anti-inflammation and anti-cancer

Direct analysis of curcumin in turmeric by DART-MS.

Hye Jin Kim et al.

Phytochemical analysis : PCA, 20(5), 372-377 (2009-06-18)

The new ion source technique, direct analysis in real time (DART) atmospheric pressure ionisation, allows high resolution mass measurements of gas, liquid and solid samples. As DART-MS produces [M + H](+) molecular ions of most compounds, relatively simple and clear

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Demethoxycurcumin