Bisdemethoxycurcumin

Name: Bisdemethoxycurcumin
Brand: SIAL
Price: 248 CHF

analytical standard

Synonym(s):

(E,E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione, Bisdesmethoxycurcumin, Curcumin III, Didemethoxycurcumin

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10 MG

CHF 248.00

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₆O₄

CAS Number:

33171-05-0

Molecular Weight:

308.33

UNSPSC Code:

85151701

NACRES:

NA.24

PubChem Substance ID:

329769933

MDL number:

MFCD03419284

Beilstein/REAXYS Number:

3149384

Key Documents

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InChI

1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+

SMILES string

Oc1ccc(cc1)\C=C\C(=O)CC(=O)\C=C\c2ccc(O)cc2

InChI key

PREBVFJICNPEKM-YDWXAUTNSA-N

grade

analytical standard

assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

Quality Level

100

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Analytical Chemistry

Analytical Chromatography

Chromatography Standards

Phytochemical Standards

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1 of 4

This Item	90593	69727	50202
Supelco 90594 Bisdemethoxycurcumin	Supelco 90593 Demethoxycurcumin	Supelco 69727 Hexahydrocurcumin	Supelco 50202 Tetrahydrocurcumin
application(s) food and beverages	application(s) food and beverages	application(s) food and beverages	application(s) food and beverages
technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable
format neat	format neat	format neat	format neat
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
grade analytical standard	grade analytical standard	grade analytical standard	grade analytical standard
assay ≥95.0% (HPLC)	assay ≥95.0% (HPLC)	assay ≥90.0% (HPLC)	assay ≥95.0% (HPLC)

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Structure-activity relationship studies of curcumin analogues.

James R Fuchs et al.

Bioorganic & medicinal chemistry letters, 19(7), 2065-2069 (2009-03-03)

Two series of curcumin analogues, a total of twenty-four compounds, were synthesized and evaluated. The most potent compound, compound 23, showed potent growth inhibitory activities on both prostate and breast cancer lines with IC(50) values in sub-micromolar range, fifty times

Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors.

Xu Qiu et al.

Bioorganic & medicinal chemistry, 16(17), 8035-8041 (2008-08-06)

Series of curcumin derivatives were synthesized; the inhibitory activities on thioredoxin reductase (TrxR) of all analogues were evaluated by DTNB assay in vitro. It is found that most of the analogues can inhibit TrxR in the low micromolar range; Structure-activity

Studies on the role of some synthetic curcuminoid derivatives in the inhibition of tumour specific angiogenesis.

P V Leyon et al.

Journal of experimental & clinical cancer research : CR, 22(1), 77-83 (2003-05-03)

In this study, some of the synthetic curcuminoid derivatives are analyzed for their anti-angiogenic activity. Intraperitoneal administration of the compounds tetrahydrocurcumin (THC), salicyl curcumin (SC) and curcuminIII (C-III) reduced the number of tumour directed capillaries induced by injecting B16F-10 melanoma

In vitro peroxynitrite scavenging activity of diarylheptanoids from Curcuma longa.

Jung Eun Kim et al.

Phytotherapy research : PTR, 17(5), 481-484 (2003-05-16)

Peroxynitrite is a cytotoxic intermediate produced by the reaction between the superoxide anion (O(2)) and nitric oxide (NO). The aim of this study was to investigate the scavenging effects of Curcuma longa L. on authentic peroxynitrite, and further studies are

Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder.

W Chearwae et al.

Biochemical pharmacology, 68(10), 2043-2052 (2004-10-13)

P-glycoprotein (Pgp, ABCB1) is an ATP-dependent drug efflux pump linked to development of multidrug resistance (MDR) in cancer cells. Previously [Biochem Pharmacol 2002;64:573-82], we reported that a curcumin mixture could modulate both function and expression of Pgp. This study focuses

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Bisdemethoxycurcumin