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E3876

Sigma-Aldrich

N-Ethylmaleimide

crystalline, ≥98% (HPLC)

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Synonym(s):
NEM
Empirical Formula (Hill Notation):
C6H7NO2
CAS Number:
Molecular Weight:
125.13
Beilstein:
112448
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

biological source

synthetic (organic)

Quality Level

Assay

≥98% (HPLC)

form

crystalline

storage condition

(Tightly closed. Dry. Keep in a well-ventilated place. )

technique(s)

activity assay: suitable
co-immunoprecipitation (co-IP): suitable
immunoblotting: suitable

color

white to faint yellow

bp

210 °C (lit.)

mp

43-46 °C (lit.)

solubility

ethanol: 50 mg/mL, clear to slightly hazy, colorless to faint yellow or tan

suitability

suitable for Western blot

application(s)

life science and biopharma

storage temp.

2-8°C

SMILES string

CCN1C(=O)C=CC1=O

InChI

1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3

InChI key

HDFGOPSGAURCEO-UHFFFAOYSA-N

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This Item
E1271C13408WH0056479M1
vibrant-m

E3876

N-Ethylmaleimide

-
vibrant-m

E1271

N-Ethylmaleimide

Premium Grade
Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

biological source

synthetic (organic)

biological source

-

biological source

synthetic (organic)

biological source

mouse

Gene Information

human ... KCNQ2(3785), KCNQ4(9132), KCNQ5(56479), SLC6A3(6531), SLC6A4(6532)

Gene Information

human ... SLC6A3(6531), SLC6A4(6532)

Gene Information

-

Gene Information

human ... KCNQ5(56479)

storage condition

(Tightly closed. Dry. Keep in a well-ventilated place. )

storage condition

-

storage condition

-

storage condition

-

solubility

ethanol: 50 mg/mL, clear to slightly hazy, colorless to faint yellow or tan

solubility

95% ethanol: 50 mg/mL, clear to slightly hazy (colorless to faint yellow)

solubility

water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

-

Application

Reagent for the covalent modification of cysteine residues in proteins.

Biochem/physiol Actions

Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.

Preparation Note

NEM gives a clear solution in ethanol at 50 mg/ml. NEM dissolves in water (>50 mg in 4 ml); however, aqueous solutions are unstable. The rate of hydrolysis is pseudo-first order and significantly dependent on pH.

Other Notes

For additional information on our range of Biochemicals, please complete this form.

comparable product

Pictograms

CorrosionSkull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

163.2 °F

Flash Point(C)

72.9 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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