L5750

Sodium dodecyl sulfate

92.5-100.5% based on total alkyl sulfate content basis

• Synonym(s): Dodecyl sodium sulfate, Dodecyl sulfate sodium salt, Lauryl sulfate sodium salt, SDS, Sodium lauryl sulfate
• Linear Formula: CH₃(CH₂)₁₁OSO₃Na
• CAS Number: 151-21-3
• Molecular Weight: 288.38
• Beilstein: 3599286
• EC Number: 205-788-1
• MDL number: MFCD00036175
• UNSPSC Code: 12161900
• eCl@ss: 39093306
• PubChem Substance ID: 24896412
• NACRES: NA.21

Properties

• description: anionic
• Quality Level: 200
• Assay: 92.5-100.5% based on total alkyl sulfate content basis
• mol wt: 288.38 g/mol
• aggregation number: 62
• CMC: 7-10 mM (20-25°C)
• mp: 204-207 °C (lit.)
• transition temp: cloud point >100 °C
• solubility: water: soluble
• HLB: 40
• SMILES string: [Na+].CCCCCCCCCCCCOS([O-])(=O)=O
• InChI: 1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1
• InChI key: DBMJMQXJHONAFJ-UHFFFAOYSA-M

Description

Application

Sodium dodecyl sulfate has been used:

• to dissolve insoluble purple formazan in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay
• to perform SDS–PAGE of yeast tubulin
• as an additive in linolenic acid solution to assess the total antioxidative activity (TAA) of the bacteria using the linolenic acid test (LA-test)

Anionic detergent

Biochem/physiol Actions

Sodium dodecyl sulfate (SDS)/lauryl sulfate, an ionic detergent has the ability to distract biological membranes. It can block RNase and deoxyribonuclease (DNase) activity. SDS is one of the main constituents of several reagents, that are used to purify nucleic acids. It is also considered as a permeability enhancer in oral formulations.

Quality

Predominantly (approx. 70%) C₁₂; lauryl sulfate, sodium salt; balance consists of higher homologs.

Analysis Note

Actual composition given on label

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H302,H315,H318,H412
• Precautionary Statements: P264 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2
• WGK: WGK 2
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves