PHR1049

Gabapentin

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): 1-(Aminomethyl)-cyclohexaneacetic acid, Neurontin
• Empirical Formula (Hill Notation): C₉H₁₇NO₂
• CAS Number: 60142-96-3
• Molecular Weight: 171.24
• Beilstein: 2359739
• EC Number: 262-076-3
• MDL number: MFCD00865286
• PubChem Substance ID: 329823079
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to USP 1287303
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: NCC1(CC(O)=O)CCCCC1
• InChI: 1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
• InChI key: UGJMXCAKCUNAIE-UHFFFAOYSA-N
• Gene Information: human ... CACNA1A(773) , CACNA1B(774) , CACNA1C(775) , CACNA1D(776) , CACNA1E(777) , CACNA1F(778) , CACNA1G(8913) , CACNA1H(8912) , CACNA1I(8911) , CACNA1S(779) , CACNA2D1(781) , CACNA2D2(9254) , CACNA2D3(55799) , CACNA2D4(93589) , CACNB1(782) , CACNB2(783) , CACNB3(784) , CACNB4(785) , CACNG1(786) , CACNG2(10369) , CACNG3(10368) , CACNG4(27092) , CACNG5(27091) , CACNG6(59285) , CACNG7(59284) , CACNG8(59283)

Description

General description

Gabapentin is an antiepileptic drug, which is a structural analog of γ-aminobu-tyric acid (GABA). It is used in the treatment of partial seizures in adults and children.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Gabapentin is an anti-convulsant drug, which leads to the irreversible inhibition of the enzyme GABA-transaminase, thereby also prevents the physiological degradation of GABA in the brain.

Application

Gabapentin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography, colorimetry and spectrophotometry.

Gabapentin may be used as a reference standard to validate the amount gabapentin present in the following:

• In human plasma samples using high performance liquid chromatography (HPLC).
• In pharmaceutical formulations using isocratic reversed-phase high performance liquid chromatography (RP-HPLC).

Gabapentin may be used pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Packaging

1 g

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAb7794 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Storage Class Code: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable