Merck
All Photos(1)

Documents

PHR1108

Supelco

L-Histidine

Pharmaceutical Secondary Standard; Certified Reference Material

Sign Into View Organizational & Contract Pricing

Synonym(s):
(S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773
Empirical Formula (Hill Notation):
C6H9N3O2
CAS Number:
Molecular Weight:
155.15
Beilstein:
84088
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to Ph. Eur. H0750000
traceable to USP 1308505

API family

histidine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

282 °C (dec.) (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

InChI key

HNDVDQJCIGZPNO-YFKPBYRVSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
7376753319H6034
vibrant-m

PHR1108

L-Histidine

-
vibrant-m

73767

L-Histidine

-
vibrant-m

53319

L-Histidine

Premium Grade
vibrant-m

H6034

L-Histidine

-
format

neat

format

neat

format

-

format

-

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

300

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

cell culture | mammalian: suitable

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, TraceCERT®

grade

-

grade

-

storage temp.

2-30°C

storage temp.

-

storage temp.

-

storage temp.

room temp

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. L-Histidine is an essential amino acid, widely present at the active sites of enzymes. It binds to metal ions and may aid in the transport of copper. It also plays an important role for the binding of heme groups, macromolecules and phosphate groups in the binding sites of proteins.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Precursor of histamine by action of histidine decarboxylase.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7159 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 10

1 of 10

L-Histidine ReagentPlus®, ≥99% (TLC)

Sigma-Aldrich

H8000

L-Histidine

Supelco

Supelco

PHR1176

Tryptophan

L-Histidine suitable for cell culture, meets EP, USP testing specifications, from non-animal source

Sigma-Aldrich

H6034

L-Histidine

L-Isoleucine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1099

L-Isoleucine

L-Alanine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1110

L-Alanine

L-Aspartic acid Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1104

L-Aspartic acid

Glycine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1111

Glycine

L-Serine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1103

L-Serine

Deacetylasperulosidic acid phyproof® Reference Substance

PHL83491

Deacetylasperulosidic acid

L-Phenylalanine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1100

L-Phenylalanine

Shweta Singh et al.
Microbial cell factories, 7, 28-28 (2008-10-14)
The large-scale production of G-protein coupled receptors (GPCRs) for functional and structural studies remains a challenge. Recent successes have been made in the expression of a range of GPCRs using Pichia pastoris as an expression host. P. pastoris has a
Urszula Kosinska Eriksson et al.
Science (New York, N.Y.), 340(6138), 1346-1349 (2013-06-15)
Aquaporins are membrane channels that facilitate the flow of water across biological membranes. Two conserved regions are central for selective function: the dual asparagine-proline-alanine (NPA) aquaporin signature motif and the aromatic and arginine selectivity filter (SF). Here, we present the
Pawel Swietach et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(22), E2064-E2073 (2013-05-17)
Ca(2+) signaling regulates cell function. This is subject to modulation by H(+) ions that are universal end-products of metabolism. Due to slow diffusion and common buffers, changes in cytoplasmic [Ca(2+)] ([Ca(2+)]i) or [H(+)] ([H(+)]i) can become compartmentalized, leading potentially to
Camilla Hofström et al.
Journal of medicinal chemistry, 56(12), 4966-4974 (2013-05-23)
Engineered affibody molecules can be used for high contrast in vivo molecular imaging. Extending a recombinantly produced HER2 binding affibody molecule with a hexa-histidine tag allows for convenient purification by immobilized metal-ion affinity chromatography and labeling with [(99m)Tc(CO)3](+) but increases
H M Golder et al.
Journal of dairy science, 97(8), 5131-5150 (2014-06-03)
Ruminal bacterial community composition (BCC) and its associations with ruminal fermentation measures were studied in dairy heifers challenged with combinations of grain, fructose, and histidine in a partial factorial study. Holstein-Friesian heifers (n=30) were randomly allocated to 5 triticale grain-based

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service