27635

Adipic acid

meets analytical specification of Ph.Eur., BP, E 355, 99.6-101.0% (calc. to the dried substance)

• Synonym(s): Hexanedioic acid
• Linear Formula: HOOC(CH₂)₄COOH
• CAS Number: 124-04-9
• Molecular Weight: 146.14
• Beilstein: 1209788
• EC Number: 204-673-3
• MDL number: MFCD00004420
• eCl@ss: 39021711
• PubChem Substance ID: 329753005

Properties

• vapor density: 5 (vs air)
• vapor pressure: 1 mmHg ( 159.5 °C)
• assay: 99.6-101.0% (calc. to the dried substance)
• form: solid
• autoignition temp.: 788 °F
• quality: meets analytical specification of Ph.Eur., BP, E 355
• impurities: residual solvents, complies; ≤0.001% heavy metals (as Pb); ≤0.2% water (Karl Fischer)
• ign. residue: ≤0.002% (as SO₄)
• loss: ≤0.2% loss on drying, 105 °C
• bp: 265 °C/100 mmHg (lit.)
• mp: 151-154 °C (lit.); 151-154 °C
• solubility: H₂O: slightly soluble; H₂O: soluble (Boiling); acetone: soluble; benzene: insoluble; cyclohexane: slightly soluble; ethanol: freely soluble; methanol: freely soluble; petroleum ether: insoluble
• anion traces: chloride (Cl^-): ≤50 mg/kg; nitrate (NO₃^-): ≤30 mg/kg; sulfate (SO₄^2-): ≤500 mg/kg
• cation traces: As: ≤3 mg/kg; Fe: ≤5 mg/kg; Hg: ≤1 mg/kg; Pb: ≤10 mg/kg; Pb: ≤5 mg/kg
• suitability: passes test for appearance of solution
• SMILES string: OC(=O)CCCCC(O)=O
• InChI: 1S/C6H10O4/c7-5(8)3-1-2-4-6(9)10/h1-4H2,(H,7,8)(H,9,10)
• InChI key: WNLRTRBMVRJNCN-UHFFFAOYSA-N

Description

Application

Adipic acid is an organic acid used for resolving the problem of pH-dependent release of weakly basic drugs.

Biochem/physiol Actions

Presence of adipic acid in the urine of ketotic patients is utilized as a marker for diagnosing the degree of ketosis.

Preparation Note

Adipic acid is freely soluble in ethanol and methanol. It also dissolves in boiling water, and acetone. Additionally, the product is slightly soluble in water and cyclohexane and is practically insoluble in benzene and petroleum ether.