If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
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For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
472301
Dimethyl sulfoxide
ACS reagent, ≥99.9%
Synonym(s):
DMSO
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About This Item
grade
ACS reagent
Quality Segment
vapor density
2.7 (vs air)
vapor pressure
0.42 mmHg ( 20 °C)
assay
≥99.9%
form
liquid
autoignition temp.
573 °F
expl. lim.
42 %, 63 °F
dilution
(for analytical testing)
impurities
≤0.001 meq/g Titr. acid, ≤0.1% water
evapn. residue
≤0.01%
color
clear colorless
refractive index
n20/D 1.479 (lit.)
bp
189 °C (lit.)
mp
16-19 °C (lit.)
density
1.10 g/mL (lit.)
SMILES string
CS(C)=O
InChI
1S/C2H6OS/c1-4(2)3/h1-2H3
InChI key
IAZDPXIOMUYVGZ-UHFFFAOYSA-N
General description
Premium ACS Solvents: Our solvents meet or exceed the stringent standards set by the American Chemical Society, ensuring high quality and reliability for your laboratory applications.
Replicable and Publishable Results: Designed for consistency, our solvents deliver results that can be reliably reproduced, making them ideal for research that requires publication.
Versatile Applications: Suitable for routine chemical synthesis, drying, purification, and critical labware cleaning, our solvents cater to a wide range of research needs in the laboratory.
Application
- in the preparation of ethyl 4-[18F]fluorobenzoate.[1]
- in the culture medium for 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay.[2]
- as a solvent in chemical synthesis.
- to dissolve and prepare stock solutions of small molecules, drugs, and chemical compounds for various assays and experiments.
Other Notes
Dimethyl Sulfoxide Miscibility/Immiscibility Table
Disclaimer
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥99.9% | assay ≥99.9% (GC) | assay ≥99.9% (GC) | assay ≥99% (GC) |
| grade ACS reagent | grade ACS reagent, puriss. p.a. | grade ACS reagent, puriss. p.a. | grade - |
| Quality Level 200 | Quality Level - | Quality Level 300 | Quality Level 100 |
| form liquid | form liquid | form liquid | form liquid |
| bp 189 °C (lit.) | bp 189 °C (lit.) | bp 189 °C (lit.) | bp 189 °C (lit.) |
| vapor pressure 0.42 mmHg ( 20 °C) | vapor pressure 0.42 mmHg ( 20 °C) | vapor pressure 0.42 mmHg ( 20 °C) | vapor pressure 0.42 mmHg ( 20 °C) |
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
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How can I determine the shelf life / expiration / retest date of this product?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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I know that this substance is of 2 types, with smell and without smell. What type is this?
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This is a high purity DMSO. While odor is not a tested specification, high purity products are expected to be odorless. A disagreeable odor is due to the sulfur moiety in the material. DMSO may also contain small amounts of un-reacted Dimethyl Sulfide (DMS). This DMS is generally contributes to a disagreeable odor.
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Can I use this DMSO for cell freezing?Is it sterile
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While DMSO is commonly used as a cryoprotectant in cell freezing, this product has not been tested for use in cell culture. This product is also not sterile. See the links below to review the sterile, cell culture tested DMSO product options:
D2438, DMSO, sterile-filtered, BioPerformance Certified, meets EP & USP testing specifications, suitable for hybridoma
https://www.sigmaaldrich.com/product/sigma/d2438D2650, sterile-filtered, Bioreagent, suitable for hybridoma
https://www.sigmaaldrich.com/product/sigma/d2650Helpful?
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Is Dimethyl sulfoxide a sterile product?
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No, this product is not considered sterile. Product Nos. D2560 and D2438 are sterile-filtered.
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Dimethyl sulfoxide (DMSO) should be a liquid. Why did it arrive as a solid?
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DMSO supercools easily, and re-melts slowly at room temperature. The melting point is 16-19 °C. The solidified product can be re-liquefied by warming to room temperature without detriment to the product.
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What is the molarity of DMSO?
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DMSO will have a molarity of 14.1M, based on a density of 1.1 g/mL and a molecular weight of 78.13 g/mol.
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Where does DMSO come from?
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DMSO is known to have been isolated from tree bark in the past. It is now a commericially synthesized solvent.
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Does DMSO have any synthetic utility?
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DMSO has been used to oxidize thiols and disulfides to sulfonic acids, hydrolysis of epoxides, thioalkylation of phenols, and oxidation of primary alcohols and halides, and esters of primary alcohols to aldehydes.
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What is the DMSO dissolved in?
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DMSO is not dissolved in any solvent. It is a pure chemical compound that is a liquid at room temperature.
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