50046

All Photos(4)

50046

Glycine

BioUltra, for molecular biology, ≥99.0% (NT)

All Photos(4)

Synonym(s):

Aminoacetic acid, Aminoethanoic acid, Glycocoll

Linear Formula:

NH₂CH₂COOH

CAS Number:

56-40-6

Molecular Weight:

75.07

Beilstein:

635782

EC Number:

200-272-2

MDL number:

MFCD00008131

eCl@ss:

32160406

PubChem Substance ID:

57651233

NACRES:

NA.26

grade

for molecular biology

Quality Level

100

product line

BioUltra

Assay

≥99.0% (NT)

form

crystalline

impurities

DNases, none detected
RNases, none detected
insoluble matter, passes filter test
phosphatases, none detected
proteases, none detected

ign. residue

≤0.05% (as SO₄)

loss

≤0.05% loss on drying, HV, 20-26 °C

color

white

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

solubility

1 M HCl: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl^-): ≤50 mg/kg
sulfate (SO₄^2-): ≤100 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
NH₄⁺: ≤200 mg/kg
Na: ≤100 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

SMILES string

NCC(O)=O

λ

1 M in 1 M HCl

UV absorption

λ: 260 nm A_max: 0.05
λ: 280 nm A_max: 0.05

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

Gene Information

rat ... Grin2a(24409)

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1 of 4

This Item	33226	G5417	G7403
Sigma-Aldrich 50046 Glycine	Sigma-Aldrich 33226 Glycine	SAFC G5417 Glycine	Sigma-Aldrich G7403 Glycine
grade for molecular biology	grade -	grade -	grade -
product line BioUltra	product line -	product line -	product line BioXtra
assay ≥99.0% (NT)	assay 99.7-101% (calc. to the dried substance)	assay ≥98.5%	assay ≥99% (titration)
form crystalline	form crystalline powder	form crystalline powder	form powder
impurities DNases, none detected, RNases, none detected, insoluble matter, passes filter test, phosphatases, none detected, proteases, none detected	impurities ≤0.001% heavy metals (as Pb), ≤0.02% ammonium (NH₄), ≤0.1% water (Karl Fischer), ≤1.0% ninhydrin-positive substances	impurities endotoxin, heavy metals, trace metals, residual solvents, tested	impurities Insoluble matter, passes filter test
color white	color -	color -	color white

Application

Glycine has been used as a component of the viral extraction mixture for adenovirus viral extraction.

Biochem/physiol Actions

Glycine is a non-essential amino acid. It is involved in the synthesis of purines, serine and porphyrins. Glycine-gated channels mediate the influx of calcium through cell membranes. It also acts as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. In cancer cells, the synthesis of glycine might be increased due to increased demand for the amino acid.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)