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91228

Sigma-Aldrich

Trichloroacetic acid

BioUltra, ≥99.5% (T)

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Synonym(s):
TCA
Linear Formula:
Cl3CCOOH
CAS Number:
Molecular Weight:
163.39
Beilstein:
970119
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

vapor density

<1 (vs air)

Quality Level

vapor pressure

1 mmHg ( 51 °C)

product line

BioUltra

Assay

≥99.5% (T)

form

crystals
flakes

impurities

insoluble matter, passes filter test

ign. residue

≤0.05%

refractive index

n20/D 1.62 (lit.)

pH

<1.0 (25 °C, 0.5 M in H2O)

bp

196 °C (lit.)

mp

54-58 °C (lit.)

solubility

H2O: 0.5 M at 20 °C, clear, colorless

density

1.62 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤30 mg/kg
nitrate (NO3-): ≤20 mg/kg
phosphate (PO43-): ≤10 mg/kg
sulfate (SO42-): ≤100 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

SMILES string

OC(=O)C(Cl)(Cl)Cl

λ

0.5 M in H2O

UV absorption

λ: 260 nm Amax: 1.60
λ: 280 nm Amax: 0.15

InChI

1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

YNJBWRMUSHSURL-UHFFFAOYSA-N

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1 of 4

This Item
T9159T4885T6399
Trichloroacetic acid BioUltra, &#8805;99.5% (T)

Sigma-Aldrich

91228

Trichloroacetic acid

Premium Grade
Trichloroacetic acid BioXtra, &#8805;99.0%

Sigma-Aldrich

T9159

Trichloroacetic acid

Premium Grade
Trichloroacetic acid &#8805;99.0% (titration)

Sigma-Aldrich

T4885

Trichloroacetic acid

-
Trichloroacetic acid ACS reagent, &#8805;99.0%

Sigma-Aldrich

T6399

Trichloroacetic acid

-
vapor pressure

1 mmHg ( 51 °C)

vapor pressure

1 mmHg ( 51 °C)

vapor pressure

1 mmHg ( 51 °C)

vapor pressure

1 mmHg ( 51 °C)

assay

≥99.5% (T)

assay

≥99.0%

assay

≥99.0% (titration)

assay

≥99.0%

form

crystals, flakes

form

-

form

-

form

-

impurities

insoluble matter, passes filter test

impurities

≤0.0005% Phosphorus (P), ≤0.1% Insoluble matter

impurities

-

impurities

Substances darkened by sulfuric acid, passes test, ≤0.01% insoluble matter

refractive index

n20/D 1.62 (lit.)

refractive index

n20/D 1.62 (lit.)

refractive index

n20/D 1.62 (lit.)

refractive index

n20/D 1.62 (lit.)

General description

Trichloroacetic acid (TCA) is derived from Trichloroethylene (TCE) metabolism. It is used as an acid decalcifying agent. TCA is used as a fixative for nuclear staining and protein precipitation.

Application

Trichloroacetic acid (TCA) has been used:
  • to determine its effect on avian embryos during an exposure window encompassing cardiac specification
  • as a cell fixative
  • to terminate the O-acetylserine (thiol)lyase (OASTL) enzymatic assay
  • for the precipitation of acidic ribosomal proteins (RPs)

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.

Other Notes

Concentration of protein by quantitative precipitation; Cytochemical demonstration of DNA with a thiazine dye

Pictograms

CorrosionEnvironment

Signal Word

Danger

Hazard Statements

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A

Storage Class Code

8B - Non-combustible, corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

> 113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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