A2383

Adenosine 5′-triphosphate disodium salt hydrate

Grade I, ≥99%, from microbial

• Synonym(s): ATP disodium salt
• Empirical Formula (Hill Notation): C₁₀H₁₄N₅Na₂O₁₃P₃ · xH₂O
• CAS Number: 34369-07-8
• Molecular Weight: 551.14 (anhydrous basis)
• EC Number: 213-579-1
• MDL number: MFCD00150755
• eCl@ss: 32160414
• PubChem Substance ID: 24890481
• NACRES: NA.51

Properties

• biological source: microbial
• Quality Level: 200
• type: Grade I
• Assay: ≥99%
• form: powder
• solubility: H₂O: 50 mg/mL
• storage temp.: −20°C
• SMILES string: O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1
• InChI key: NTBQNWBHIXNPRU-MSQVLRTGSA-L

Description

Application

Adenosine 5′-triphosphate disodium salt hydrate has been used:

• to prepare adenosine triphosphate (ATP) standard solutions to determine ATP levels in various bacterial cultures
• bone marrow-derived macrophages (BMDM) treatment
• as a preparation free of contaminating guanine nucleotides to study the binding effects of coatomer β subunit (β-COP)

Biochem/physiol Actions

Adenosine 5′-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is used in many cellular processes, respiration, biosynthetic reactions, active transport, and motility. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase that produce the secondary messenger cyclic adenosine monophosphate (cAMP). ATP provides the metabolic energy to drive metabolic pumps. It serves as a coenzyme in a wide array of enzymatic reactions.

P₂ purinergic agonist; increases activity of Ca²⁺-activated K⁺ channels; substrate for ATP-dependent enzyme systems

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves