A9187

Sigma-Aldrich

Adenosine 5′-triphosphate magnesium salt

≥95%, bacterial

Synonym(s):
ATP magnesium salt
Empirical Formula (Hill Notation):
C10H16N5O13P3 · xMg2+
CAS Number:
Molecular Weight:
507.18 (free acid basis)
MDL number:
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.51

Quality Level

biological source

bacterial

assay

≥95%

solubility

H2O: 50 mg/mL

storage temp.

−20°C

SMILES string

[Mg].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C3O

InChI

1S/C10H16N5O13P3.Mg.2H/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;

InChI key

CPGAIACWYFBIFN-UHFFFAOYSA-N

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Related Categories

Application

Adenosine 5′-triphosphate magnesium salt has been used:
  • as a supplement in intracellular medium for Ca2+ retention assay and fluorescence wide field imaging analysis
  • as a component in potassium methane sulfonate-based internal solution for in vitro electrophysiology of cortical neurons
  • as a component in action potential intracellular solution

Packaging

100, 500 mg in poly bottle
1 g in poly bottle

Biochem/physiol Actions

Adenosine 5γ-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is use in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. ATP serves as a coenzyme in a wide array of enzymatic reactions.
P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems

pictograms

Health hazard

signalword

Warning

hcodes

pcodes

hazcat

STOT SE 2

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificate of Analysis

Certificate of Origin

Hyun Jong Kim et al.
European journal of pharmacology, 791, 686-695 (2016-10-30)
Pyrazole derivatives were originally suggested as selective blockers of the transient receptor potential cation 3 (TRPC3) and channel. In particular, pyr3 and 10 selectively inhibit TRPC3, whereas pyr2 (BTP2) and 6 inhibit ORAI1. However, their effects on background K+ channel...
Lea Wagmann et al.
Archives of toxicology, 92(9), 2875-2884 (2018-08-08)
Transporter-mediated drug-drug interactions (DDI) may induce adverse clinical events. As drugs of abuse (DOA) are marketed without preclinical safety studies, only very limited information about interplay with membrane transporters are available. Therefore, 13 DOA of various classes were tested for...
Spatial separation of mitochondrial calcium uptake and extrusion for energy-efficient mitochondrial calcium signaling in the heart.
De La Fuente S, et al.
Cell reports, 24(12), 3099-3107 (2018)
A subpopulation of striatal neurons mediates Levodopa-induced dyskinesia.
Girasole AE, et al.
Neuron, 97(4), 787-795 (2018)
Lea Wagmann et al.
Journal of chromatography. A, 1521, 123-130 (2017-09-28)
Interactions with the human breast cancer resistance protein (hBCRP) significantly influence the pharmacokinetic properties of a drug and can even lead to drug-drug interactions. As efflux pump from the ABC superfamily, hBCRP utilized energy gained by adenosine 5'-triphosphate (ATP) hydrolysis...

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