Merck
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C7165

Sigma-Aldrich

Citrate-phosphate-dextrose solution

aseptically filled

Synonym(s):
Citrate-phosphate-glucose
NACRES:
NA.25

sterility

aseptically filled

Quality Level

form

liquid

pH

5.2-5.8

storage temp.

2-8°C

Related Categories

General description

Citrate-phosphate-dextrose solution (CPD) is an anticoagulant solution. It has 15% less citrate ion over citrate-phosphate-dextrose solution with adenine (ACD) and provides improved isotonicity, oxygen release function and posttransfusion viability for red blood cells.

Application

Citrate-phosphate-dextrose solution has been used as an anti-coagulant in bovine blood. It has also been used in the storage of fluorescein isothiocyanate (FITC) labeled erythrocytes. Citrate-phosphate-dextrose solution is suitable for erythrocyte survival studies and whole blood storage.

Other Notes

Suggested anticoagulant: whole blood ratio: 1:14

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

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  5. For the anticoagulant Product C7165, Citrate-Phosphate-Dextrose solution, what is the proper anticoagulant to whole blood ratio to use?

    Our search of the literature shows that Citrate-Phosphate-Dextrose solution is typically used at a ratio of 1:7 or 1:9, but we do indeed test it at 1:14...the thinking being that if it works at 1:14, it will surely work at 1:7 or 1:9. The description of Product C7165, Citrate-Phosphate-Dextrose solution, suggests using it at an anticoagulant to whole blood ratio of 1.4 to 10 (about 1:7), but the specification sheet shows that it is tested at an anticoagulant to whole blood ratio of 1:14.

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Citrate phosphate dextrose (CPD) anticoagulant in blood transfusion
McCullough J and Weiblen BJ
Minnesota Medicine, 56(11), 980-982 (1973)
J J Macoskey et al.
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Malaria journal, 7, 243-243 (2008-11-26)
Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes (IE) is a parasite adhesion phenotype that has been associated with severe malaria in some, but not all, field isolate studies. A variety of experimental conditions have been used to study clumping in vitro
Alexander P Duryea et al.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 62(12), 2068-2078 (2015-12-17)
Remanent bubble nuclei generated by primary cavitation collapse can limit the efficiency of histotripsy softtissue fractionation. When these residual bubbles persist from one histotripsy pulse to the next, they can seed the repetitive nucleation of cavitation bubbles at a discrete

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