F6889

Famotidine

• Synonym(s): N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine
• Empirical Formula (Hill Notation): C₈H₁₅N₇O₂S₃
• CAS Number: 76824-35-6
• Molecular Weight: 337.45
• MDL number: MFCD00079297
• PubChem Substance ID: 24278442
• NACRES: NA.77

Properties

• Quality Level: 100
• originator: Johnson & Johnson
• SMILES string: N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1
• InChI: 1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
• InChI key: XUFQPHANEAPEMJ-UHFFFAOYSA-N
• Gene Information: human ... HRH2(3274)

Description

Application

Famotidine has been used to test its effect on the human ether-a-go-go-related gene (hERG) binding transfected in HEK293 membrane. It has also been used in polycaprolactone based drug delivery studies.

Packaging

500 mg

1, 5 g

Biochem/physiol Actions

Famotidine is not effective on muscarinic and nicotinic receptors. It competitively inhibits the secretion of gastric acid and elicits mucosal injury protection.

H₂ histamine receptor antagonist; anti-ulcer agent

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves