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F6889

Sigma-Aldrich

Famotidine

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Synonym(s):
N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine
Empirical Formula (Hill Notation):
C8H15N7O2S3
CAS Number:
Molecular Weight:
337.45
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

originator

Johnson & Johnson

SMILES string

N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1

InChI

1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

InChI key

XUFQPHANEAPEMJ-UHFFFAOYSA-N

Gene Information

human ... HRH2(3274)

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1 of 4

This Item
BP6531269200PHR1055
vibrant-m

F6889

Famotidine

vibrant-m

BP653

Famotidine

vibrant-m

1269200

Famotidine

vibrant-m

PHR1055

Famotidine

originator

Johnson & Johnson

originator

-

originator

-

originator

-

Gene Information

human ... HRH2(3274)

Gene Information

human ... HRH2(3274)

Gene Information

human ... HRH2(3274)

Gene Information

human ... HRH2(3274)

Application

Famotidine has been used to test its effect on the human ether-a-go-go-related gene (hERG) binding transfected in HEK293 membrane. It has also been used in polycaprolactone based drug delivery studies.

Biochem/physiol Actions

Famotidine is not effective on muscarinic and nicotinic receptors. It competitively inhibits the secretion of gastric acid and elicits mucosal injury protection.
H2 histamine receptor antagonist; anti-ulcer agent

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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USP

USP

1269232

Famotidine Related Compound C

vibrant-m

Y0000409

Famotidine impurity D

Ranitidine hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1598405

Ranitidine hydrochloride

Lansoprazole ≥98% (TLC), powder

Sigma-Aldrich

L8533

Lansoprazole

Enalaprilat analytical standard

Supelco

43301

Enalaprilat

Furosemide

Sigma-Aldrich

F4381

Furosemide

Omeprazole solid

Sigma-Aldrich

O104

Omeprazole

Cantharidin

Sigma-Aldrich

C7632

Cantharidin

Acycloguanosine ≥99% (HPLC), powder

Sigma-Aldrich

A4669

Acycloguanosine

Minoxidil ≥99% (TLC)

Sigma-Aldrich

M4145

Minoxidil

Polycaprolactone thin-film drug delivery systems: empirical and predictive models for device design
Schlesinger E, et al.
Materials Science and Engineering, C, 57, 232-239 (2015)
Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs
Taha AS, et al.
The New England Journal of Medicine, 334(22), 1435-1439 (1996)
Famotidine: an update review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied disease
Healther DL, et al.
Drugs, 38(3), 551-590 (2015)
Makoto Anraku et al.
International journal of pharmaceutics, 487(1-2), 142-147 (2015-04-18)
An intermolecular complex formed from a 1:1 weight ratio of chitosan (CS, molecular weight 30 kDa) and sulfobutyl ether β-cyclodextrin (SBE-β-CyD, degree of substitution 7) was less soluble than either of the original components. The release of famotidine from tablets
The [3H] dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+] o
Diaz GJ, et al.
Journal of Pharmacological and Toxicological Methods, 50(3), 187-199 (2004)

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