All Photos(5)

G7879

Sigma-Aldrich

D-Glucose 6-phosphate sodium salt

crystalline

Synonym(s):
Robison ester, D(+)-Glucopyranose 6-phosphate sodium salt, G-6-P Na
Empirical Formula (Hill Notation):
C6H12NaO9P
CAS Number:
Molecular Weight:
282.12
Beilstein:
5787568
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Quality Level

biological source

synthetic (organic)

assay

≥98% (HPLC)

form

crystalline

application(s)

HPLC: suitable

mp

204 °C (dec.) (lit.)

SMILES string

[Na+].O[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H](O)[C@H]1O

InChI

1S/C6H13O9P.Na/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8;/h2-10H,1H2,(H2,11,12,13);/q;+1/p-1/t2-,3-,4+,5-,6-;/m1./s1

InChI key

ZALKNDISPIVVKC-WYRLRVFGSA-M

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Application

D-glucose-6-phosphate sodium can be used as an energy source for Mycobacterium tuberculosis.

Packaging

500 mg in poly bottle
1, 5, 25 g in poly bottle

Biochem/physiol Actions

In cells, D-glucose 6-phosphate (G6P) is generated when glucose is phosphorylated by hexokinase or glucokinase or by the conversion of glucose-1-phosphate by phosphoglucomutase during glycogenolysis. G6P lies at the beginning of both glycolysis and the pentose phosphate pathways. It also can be stored as glycogen when blood glucose levels are high.

Caution

Non-hygroscopic, and very stable to atmospheric moisture at room temperature, unlike the disodium salt.

Storage Class Code

11 - Combustible Solids

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Iain J Abbott et al.
Antimicrobial agents and chemotherapy, 64(6) (2020-04-08)
There are limited treatment options for enterococcal urinary tract infections, especially vancomycin-resistant Enterococcus (VRE). Oral fosfomycin is a potential option, although limited data are available guiding dosing and susceptibility. We undertook pharmacodynamic profiling of fosfomycin against E. faecalis and E....
Iain J Abbott et al.
The Journal of antimicrobial chemotherapy, 75(4), 988-996 (2019-12-25)
To assess the antibacterial effects of a single 3 g oral fosfomycin dose on Escherichia coli and Klebsiella pneumoniae clinical isolates within a dynamic bladder infection model. An in vitro model simulating dynamic urinary fosfomycin concentrations was used. Target fosfomycin exposure...
Iain J Abbott et al.
Antimicrobial agents and chemotherapy, 64(3) (2020-01-08)
Oral fosfomycin trometamol is licensed as a single oral dose for the treatment of uncomplicated urinary tract infections, with activity against multidrug-resistant uropathogens. The impact of interindividual variability in urinary concentrations on antimicrobial efficacy, and any benefit of giving multiple...
Iain J Abbott et al.
Journal of microbiological methods, 171, 105861-105861 (2020-02-09)
The impact of the bladder environment on fosfomycin activity and treatment response is uncertain. Standard laboratory media does not reflect the biomatrix of urine, where limited nutritional factors are important for growth and antimicrobial kill rates. We compared fosfomycin activity...
Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes.
Carter, et al.
Cell Metabolism, 32, 561-574 (2021)

Articles

Nucleotide Synthesis in Cancer Cells

Neoplastic cells are highly dependent on the de novo synthesis of nucleotides to maintain sufficient pools to support DNA replication and the production of RNA.

Insulin Signaling and Energy Homeostasis

Glucose metabolism is regulated by the opposing actions of insulin and glucagon. Insulin is released from pancreatic ß cells in response to high blood glucose levels and regulates glucose metabolism through its actions on muscle, liver, and adipose tissue.

Aerobic Glycolysis and the Warburg Effect

We presents an article about the Warburg effect, and how it is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not.

Protocols

Enzymatic Activity of Glucose-6-Phosphatase [EC 3.1.3.9]

Objective: To standardize a procedure for the enzymatic determination of Glucose-6-phosphatase activity

Enzymatic Assay of Glucose-6-Phosphate Dehydrogenase (EC 1.1.1.49)

Enzymatic Assay of Glucose-6-Phosphate Dehydrogenase (EC 1.1.1.49)

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