H2O: 50 mg/mL
human ... HRAS(3265)
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ZIC-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.
HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC
HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.
Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.