Merck
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H2779

Sigma-Aldrich

HistoChoice® Clearing Agent

greener alternative
NACRES:
NA.47

form

liquid

Quality Level

greener alternative product characteristics

Designing Safer Chemicals
Learn more about the Principles of Green Chemistry.

color

colorless

density

0.760-0.820 g/mL

application(s)

hematology
histology

greener alternative category

Aligned

storage temp.

room temp

General description

HistoChoice® is a patented, complex mixture of agents that allow tissues to retain their structure, antigenic sites and nucleic acid sites. This formulation in non-citrus, contains no mercury, formaldehyde or glutaraldehyde.

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has Inherently Safer Chemistry, compared to the standard use of formalin for tissue processing.

Application

HistoChoice® Clearing Agent is suitable as an alternative to toluene and xylene for dewaxing paraffin tissue sections. Prepared slides are suitable for antibody probing applications and in situ hybridizations.

Features and Benefits

  • Non-toxic and odorless
  • Preserves native antigenic and nucleic acid sites
  • Tissues retain original structure

Legal Information

HistoChoice is a registered trademark of Amresco, Inc.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

142.0 °F

Flash Point(C)

61.1 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Is HistoChoice Clearing Agent, product H2779, compatible with polycarbonate?

    The supplier of HistoChoice Clearing Agent has reported no incompatibilities were observed when polycarbonate was exposed to HistoChoice Clearning Agent for at least 1 hour.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Uthpala Apekshani Jayawardena et al.
Environmental toxicology and chemistry, 36(10), 2855-2867 (2017-05-06)
Heavy metal contamination may have adverse effects on wetland biota, particularly on amphibians. Severe immunotoxic effects elicited in Euphlyctis hexadactylus (Indian green frog) because of metal exposure (Cd, Cr, Cu, Pb, and Zn) in the Bellanwila-Attidiya Sanctuary, a polluted urban
Bjarke Veierskov et al.
American journal of botany, 95(6), 766-771 (2008-06-01)
Meristematic activity in the bud meristem of Abies nordmanniana was visualized by ubiquitin immunohistochemical localization from before bud break and throughout shoot expansion. Ubiquitin was detected in meristematic cells either in the cytosol or nucleus, or both, depending on tissue
Sathyanesan Samuel Newton et al.
Brain research. Brain research protocols, 9(3), 214-219 (2002-07-13)
A method is described to perform combined immunohistochemistry and in situ hybridization in mouse brain sections. The protocol is specific to sections mounted on glass slides. In contrast to earlier methods that require either paraffin embedding or perfusion of the
Anita S Patel et al.
The Journal of investigative dermatology, 128(12), 2888-2893 (2008-06-13)
An increasing number of studies report that genus beta human papillomaviruses (HPVs) are associated with skin cancer, with suggestions of specificity for squamous cell carcinoma (SCC) of the skin. We have conducted a systematic examination of HPV DNA in tumors
Janine A Duckworth et al.
Reproduction (Cambridge, England), 133(1), 177-186 (2007-01-25)
In a previous study, three infertility-relevant epitopes of possum ZP2 (Pep12 (amino acids 111-125), Pep31 (amino acids 301-315), and Pep44 (amino acids 431-445)) were identified using sera from possums (Trichosurus vulpecula) immunized with recombinant possum zona pellucida 2 (ZP2) constructs

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