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I6125

Sigma-Aldrich

Iodoacetamide

≥99% (NMR), crystalline

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Synonym(s):
α-Iodoacetamide, 2-Iodoacetamide
Linear Formula:
ICH2CONH2
CAS Number:
Molecular Weight:
184.96
Beilstein:
1739080
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

Assay

≥99% (NMR)

form

crystalline

mp

92-95 °C (lit.)

solubility

H2O: soluble 0.5 M, clear, colorless

storage temp.

2-8°C

SMILES string

NC(=O)CI

InChI

1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)

InChI key

PGLTVOMIXTUURA-UHFFFAOYSA-N

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This Item
I1149A3221407710
Iodoacetamide ≥99% (NMR), crystalline

Sigma-Aldrich

I6125

Iodoacetamide

-
Iodoacetamide BioUltra

Sigma-Aldrich

I1149

Iodoacetamide

Premium Grade
Iodoacetamide Single use vial of 56 mg

Sigma-Aldrich

A3221

Iodoacetamide

-
Sigma-Aldrich

Sigma-Aldrich

407710

α-Iodoacetamide

-
assay

≥99% (NMR)

assay

≥99% (NMR)

assay

≥99% (HPLC)

assay

≥99% (HPLC)

form

crystalline

form

powder

form

powder

form

crystalline solid

mp

92-95 °C (lit.)

mp

92-95 °C (lit.)

mp

92-95 °C (lit.)

mp

-

solubility

H2O: soluble 0.5 M, clear, colorless

solubility

H2O: 0.5 M, clear, colorless

solubility

H2O: soluble 50 mg/mL, clear, colorless to faintly yellow

solubility

methanol: 1:20, DMF: soluble, ethanol: soluble, water: soluble

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

Biochem/physiol Actions

Iodoacetamide acts as an alkylating reagent for cysteine residues in peptide sequencing. It is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibiting ribonuclease.

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4 - Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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