Merck
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I9016

Sigma-Aldrich

Anti-Interferon-γ antibody produced in goat

IgG fraction of antiserum

Synonym(s):
Anti-IFN-γ
EC Number:
MDL number:
NACRES:
NA.41

biological source

goat

Quality Level

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

technique(s)

neutralization: suitable
western blot: suitable

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... IFNG(3458)

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General description

Interferons (IFNs) are cytokines that are secreted in response to viral or bacterial infections and tumorigenesis. There are two types of IFNs, type I (IFN-α and IFN-β) and type II (IFN-γ). IFN-γ binds to specific receptor complex consisting of IFNγR1 and IFNγR2.[1][2] There are many pathways that are mediated by IFN-γ binding such as JAK/STAT1, AP-1, NF-κB, STAT3 and STAT5.[3][4] IFN-γ is pleotropic and performs various functions related to immune response, inflammation, differentiation and activation of T cells, cell cycle and apoptosis. The most studied function of IFN-γ is priming the antigen presenting cells by upregulating major histocompatibility (MHC) Class I molecules.[1][4] IFN-γ has clinical applications in autoimmune diseases (rheumatoid arthritis), multiple sclerosis, cancer, HIV and fungal infections[1][5]
Anti-Interferon-γ recognizes human Interferon-γ. It does not bind specifically to mouse, hamster or bovine IFN-γ.

Specificity

The antibody shows no cross-reactivity with recombinant mouse IFN-γ.

Immunogen

recombinant human IFN-γ.

Application

Anti-interferon-γ antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. The antibody is suitable for neutralization reactions.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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