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L090000

Sigma-Aldrich

Dichloromethane

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Synonym(s):
Methylene chloride
Empirical Formula (Hill Notation):
CH2Cl2
CAS Number:
Molecular Weight:
84.93
Beilstein:
1730800
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

vapor density

2.9 (vs air)

Quality Level

vapor pressure

24.45 psi ( 55 °C)
6.83 psi ( 20 °C)

type

for DNA synthesis

product line

Proligo Reagents

form

liquid

autoignition temp.

1223 °F

contains

amylene as stabilizer

expl. lim.

22 %

storage condition

dry at room temperature

impurities

≤50 ppm water content (Karl Fischer)

color

clear

refractive index

n/D 1.421-1.425
n20/D 1.424 (lit.)

bp

39.8-40 °C (lit.)

mp

−95 °C (lit.)

density

1.325 g/mL at 25 °C (lit.)

SMILES string

ClCCl

InChI

1S/CH2Cl2/c2-1-3/h1H2

InChI key

YMWUJEATGCHHMB-UHFFFAOYSA-N

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This Item
2709972423334856
Dichloromethane

L090000

Dichloromethane

-
Dichloromethane anhydrous, ≥99.8%, contains 40-150 ppm amylene as stabilizer

270997

Dichloromethane

-
Dichloromethane puriss., meets analytical specification of Ph. Eur., NF, ≥99% (GC)

24233

Dichloromethane

Essential Grade
Dichloromethane suitable for HPLC, ≥99.8%, contains amylene as stabilizer

34856

Dichloromethane

-
form

liquid

form

liquid

form

liquid

form

liquid

density

1.325 g/mL at 25 °C (lit.)

density

1.325 g/mL at 25 °C (lit.)

density

1.318-1.322 g/mL at 25 °C, 1.325 g/mL at 25 °C (lit.)

density

1.325 g/mL at 25 °C (lit.)

vapor pressure

24.45 psi ( 55 °C), 6.83 psi ( 20 °C)

vapor pressure

24.45 psi ( 55 °C), 6.83 psi ( 20 °C), 6.86 psi ( 20 °C)

vapor pressure

24.45 psi ( 55 °C), 6.83 psi ( 20 °C)

vapor pressure

24.45 psi ( 55 °C), 6.83 psi ( 20 °C)

autoignition temp.

1223 °F

autoignition temp.

1223 °F

autoignition temp.

1223 °F

autoignition temp.

1223 °F

impurities

≤50 ppm water content (Karl Fischer)

impurities

≤0.001% water, ≤0.005% water (100 mL pkg)

impurities

residual solvents, complies, ≤0.0001% free chlorine (Cl), ≤0.001% carbon tetrachloride (GC), ≤0.001% free acid (as HCl), ≤0.002% non-volatile matter, ≤0.005% trichloromethane (GC), ≤0.02% methanol (GC), ≤0.02% water (Karl Fischer), ≤1 ppm heavy metals (as Pb), ≤2.0% ethanol (GC)

impurities

free chlorine, in accordance, ≤0.001% free acid (as HCl), ≤0.001% non-volatile matter, ≤0.02% water (Karl Fischer)

General description

In the solid-phase synthesis of oligonucleotides, liquid reagents are used in each step of the synthesis cycle. Overall synthesis performance, and therefore total product yield and purity of the crude oligonucleotide, is highly dependent on the chemical purity of the monomers and the supporting liquid reagents and other solvents like ethylacetate, dichloromethane, and dimethylformadine .Dichloromethane is an ordinary organic solvent frequently utilized in peptide synthesis. Under normal circumstances, DCM maintains highly stable and will not cause significant side reactions in peptide synthesis. It is a chlorinated organic solvent that is susceptible to degradation with time. This can be suppressed by adding amylene as a stabilizer.Dichloromethane has been tested as a solvent medium for the dipyridine-chromium(VI) oxide. Solubility was reported to be 12.5g/100ml. The role of the quantity of TiO2 loading on activated carbon support employed in the photodecomposition of dichloromethane has been investigated.

Application

Dichloromethane may be used as a solvent for the preparation of stock solutions of carotenoids. It may be employed as a solvent in the synthesis of polylactide-based (PLA) thin films. IT is also suitable as a solvent for the oxidation of primary and secondary alcohols using dipyridine-chromium(VI) oxide.

Pictograms

Exclamation markHealth hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 2

Flash Point(F)

does not flash

Flash Point(C)

does not flash


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