β-Nicotinamide adenine dinucleotide 2′-phosphate reduced tetrasodium salt hydrate

≥97% (HPLC)

β-NADPH, Coenzyme II reduced tetrasodium salt, 2′-NADPH hydrate, Triphosphopyridine nucleotide reduced tetrasodium salt, NADPH Na4, TPNH2 Na4, Dihydronicotinamide adenine dinucleotide phosphate tetrasodium salt
Empirical Formula (Hill Notation):
C21H26N7Na4O17P3 · xH2O
CAS Number:
Molecular Weight:
833.35 (anhydrous basis)
EC Number:
MDL number:
PubChem Substance ID:

Quality Level


≥97% (HPLC)
≥97% (spectrophotometric assay)


10 mM NaOH: soluble 50 mg/mL, clear

storage temp.


SMILES string




InChI key


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25, 100, 250, 500 mg in poly bottle
1 g in poly bottle

Biochem/physiol Actions

NADPH is an electron donor and a cofactor for many redox enzymes including nitric oxide synthetase.
β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP).

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Preparation Note

Chemically reduced

Other Notes

Packaged based on solid weight.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC


11 - Combustible Solids

WGK Germany


Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Yan Cai et al.
Experimental neurology, 216(2), 342-356 (2009-01-27)
DCX-immunoreactive (DCX+) cells occur in the piriform cortex in adult mice and rats, but also in the neocortex in adult guinea pigs and rabbits. Here we describe these cells in adult domestic cats and primates. In cats and rhesus monkeys...
Berg, J.M., et al.
Biochemistry (5th Edition) (2002)
Kun Xiong et al.
Experimental neurology, 211(1), 271-282 (2008-04-02)
Doublecortin-immunoreactive (DCX+) cells were detected across the allo- and neo-cortical regions in the adult guinea pig cerebrum, localized to layer II specifically at its border with layer I. The density of labeled cells declined with age, whereas no apparent apoptotic...
William B. Wood
Biochemistry: A Problems Approach, 195-195 null
Allen T Hopper et al.
Journal of medicinal chemistry, 62(3), 1562-1576 (2019-01-10)
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