Merck
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SML1537

Sigma-Aldrich

Cantharidin Ready Made Solution

0.1 mg/mL in DMSO

Synonym(s):
3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione, 7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran, Cantharidine, Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione
Empirical Formula (Hill Notation):
C10H12O4
CAS Number:
Molecular Weight:
196.20
EC Number:

biological source

insect

Quality Level

form

solution

concentration

0.1 mg/mL in DMSO

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-

InChI key

DHZBEENLJMYSHQ-XCVPVQRUSA-N

Biochem/physiol Actions

It is a component of mylabris, a traditional Chinese medicine. Cantharidin exhibits anti-tumor activity. In addition, cantharidin can work against multidrug-resistant cells. In the epidermis, it causes release of neutral serine proteases, leading to degeneration of the desmosmal plaque. This results in acantholysis and intraepidermal blistering as well as skin lysis. PP2A is involved in the cell cycle, cell death, growth and cell-fate determination.
Cantharidin inhibits protein phosphatase 2A.

Other Notes

Stable for at least two years at 2-8° C.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

188.6 °F

Flash Point(C)

87 °C

Certificate of Analysis

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Certificate of Origin

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