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1609002

USP

Salicylic acid

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):
2-Hydroxybenzoic acid
Linear Formula:
2-(HO)C6H4CO2H
CAS Number:
Molecular Weight:
138.12
Beilstein:
774890
MDL number:
PubChem Substance ID:

grade

pharmaceutical primary standard

vapor density

4.8 (vs air)

vapor pressure

1 mmHg ( 114 °C)

API family

salicylic acid

manufacturer/tradename

USP

bp

211 °C (lit.)

mp

158-161 °C (lit.)

solubility

alcohol: freely soluble
benzene: slightly soluble
boiling water: soluble
chloroform: sparingly soluble
ether: freely soluble
toluene: slightly soluble
water: slightly soluble

density

1.44 g/cm3 at 20 °C

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

OC(=O)c1ccccc1O

InChI

1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)

InChI key

YGSDEFSMJLZEOE-UHFFFAOYSA-N

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1 of 4

This Item
S0200000BP77584210
Salicylic acid United States Pharmacopeia (USP) Reference Standard

USP

1609002

Salicylic acid

Salicylic acid European Pharmacopoeia (EP) Reference Standard

S0200000

Salicylic acid

Salicylic acid British Pharmacopoeia (BP) Reference Standard

BP775

Salicylic acid

Salicylic acid puriss. p.a., ≥99.0% (T)

Sigma-Aldrich

84210

Salicylic acid

manufacturer/tradename

USP

manufacturer/tradename

EDQM

manufacturer/tradename

BP

manufacturer/tradename

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical

application(s)

-

format

neat

format

neat

format

neat

format

-

vapor density

4.8 (vs air)

vapor density

4.8 (vs air)

vapor density

4.8 (vs air)

vapor density

4.8 (vs air)

vapor pressure

1 mmHg ( 114 °C)

vapor pressure

1 mmHg ( 114 °C)

vapor pressure

1 mmHg ( 114 °C)

vapor pressure

1 mmHg ( 114 °C)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Salicylic acid USP reference standard for use in specified quality tests and assays.

Also used to prepare standard solutions for the assay, impurity analysis, and performance test by using liquid chromatography in conjunction with a UV detector according to the given below monographs of United States Pharmacopeia (USP) :
  • Salicylic Acid
  • Methyl Salicylate
  • Magnesium Salicylate Tablets
  • Aspirin Boluses

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued certificate and SDS can be found here.
Sales restrictions may apply.

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

314.6 °F - closed cup

Flash Point(C)

157 °C - closed cup


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Salicylic acid

Salicylic Acid
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(6), 3970-3970 (2020)
Methyl Salicylate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 46(3) (2021)
Magnesium Salicylate Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 40(4), 2724-2724 (2015)
Aspirin Boluses
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(4), 388-388 (2017)
Jyoti Shah
Current opinion in plant biology, 6(4), 365-371 (2003-07-23)
Salicylic acid is an important signal molecule in plant defense. In the past two years, significant progress has been made in understanding the mechanism of salicylic-acid biosynthesis and signaling in plants. A pathway similar to that found in some bacteria

Protocols

Separation of Acetylsalicylic acid, analytical standard; Salicylic acid, BioXtra, ≥99.0%

Separation of Salicylic acid, meets analytical specification of Ph. Eur., BP, USP, 99.5-100.5% (calc. to the dried substance); Acetylsalicylic acid, purum, ≥99.0% (HPLC)

HPLC Analysis of Benzoic Acid Derivatives on Ascentis® C18

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