Chemical Biology Tools

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Dexterity Kits

Dexterity Kits are an easy, all-in-one method to perform high sensitivity proximity labeling for any protein as long as there is a known antibody or small molecule specific for their protein of interest (POI). These protein labeling kits allow you to perform precise micromapping within 4 nm of your POI. Dexterity Kits provide:

  • Facile incorporation of small molecules as an amide linkage, either with an amine or acid group
  • Short labeling radius
  • Benign method of activation (visible light)
  • Catalytic signal amplification

DNA-Encoded Libraries (DELs)

DNA Encoded Fragment Library

The fragment DELs from our partner DyNAbind provides an entire screening library in a single tube, making your drug discovery process faster, more effective, and less expensive. We’ve lowered the barriers to DyNAbind DEL technology to provide:

  • Off-the-shelf, affordable access to DEL technology
  • Dynamic fragment library for a revolutionary approach to screening with DELs
  • High-level quality control of every fragment component maximizes data reliability and validation of good hits
  • Rule-of-Three used in library design ensures compounds are in favorable fragment space with good ligand efficiency and plenty of room for optimization
  • Ability to perform and validate initial DEL screening internally before engaging service provider
  • A library with maximized diversity, ready to deploy against nearly any druggable target

10 Million Compound DNA-Encoded Library (DEL)

This DNA-encoded library from our partner DyNAbind contains a library of 10 million small molecule compounds each tagged with a DNA barcode. This DEL provides:

  • 10 Million compound, off-the-shelf, affordable DEL
  • Fits in a single microcentrifuge tube
  • No sophisticated robotics required to use the kit
  • Rapid assay by binding, washing, PCR, and next gen sequencing
  • Free analysis on our website portal
  • Structures are revealed for 50 hits or up to 60 with ties at no additional charge
  • The label license allows any use of hits in research and development or manufacturing at no additional charge

Chemical Probes and Tools

Probe Building Blocks: Design Your Own Probe

With our selection of reactive groups, scaffolds, linkers and tags, you can design probes to include functionalities compatible for:

  • Target engagement
  • Enrichment
  • Fluorescence
  • Bioorthogonal chemistries

Target-Based Probes: Selective and Characterized

Choose from probes with high-specificity for one target or subset of a protein to provide insight into biological processes, protein activity and localization, and cell signaling networks.

Bioorthogonal Reporter Tags: Investigate Without Interference

Probes containing an alkyne, azide or tetrazine handle are paired with bioorthogonally compatible fluorescent or biotinylated tags

Baseclick EdU Cell Proliferation Monitoring Kits: Rapid Quantification of Cell Growth

Detect cell proliferation especially for in vivo experiments with the EdU nucleoside:

  • Nontoxic to animals
  • Directly incorporated into replicating DNA
  • Contains an alkyne handle for click chemistry labeling with azide florescent probes

Boger Serine Hydrolase Inhibitors: An Irreversible Bind

Access a library of molecules from the Dale Boger lab with broad spectrum inhibition of the serine hydrolase family. Tune the compounds to a desired reactivity and selectivity through functional group attachment at an amine site and develop inhibitors to specific subclasses of serine hydrolase enzymes.

Quorum Sensing Modulators: Interfere with Bacterial Signaling

Quorum sensing is a chemical communication mechanism used by many common bacteria. New quorum sensing modulators developed by the Helen Blackwell laboratory are some of the most potent inhibitors and activators reported for Gram-negative species.


Crosslinkers: A Variety of Linkers for a Variety of Biological Needs

We offer crosslinkers that vary in length, solubility and functional group reactivity.

  • Common bioconjugation linkers including NHS esters for amines or maleimide for thiols
  • Improved thiol coupling with APN reactivity
  • Enhanced solubility with sulfo-NHS esters and PEGylated linkers
  • Cleavable crosslinkers also available

We also provide crosslinkers designed for click chemistry reactivity.

  • Azide and alkyne linkers for copper click chemistry
  • Dibenzocyclooctyne (DBCO), azide, tetrazine or transcyclooctyne for copper-free click chemistry

Potassium Acyltrifluoroborates (KATs): A New Approach to Bioconjugation

As a unique class of functional groups, KATS:

  • Offer innovative approaches to protein conjugation and hydrogel formation
  • Undergo rapid, chemoselective amide-forming reactions under aqueous conditions without the need for activating agents or protecting groups

Late Stage Conjugation: Native Chemical Tagging of Bioactive Small Molecules

We offer Baran Diversinate crosslinkers with a metal sulfinate on one end to attach directly to otherwise inert C-H bonds and an azide on the other end for attaching to alkynes. We offer various alkyne and strained alkyne crosslinkers for attachment to the azide crosslinker.

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