Benefiting from our leading bioprocess knowledge and engineering expertise in tangential flow filtration (TFF), we have developed multi-use, single-use, and process development systems incorporating many unique, innovative, and intelligent features. Our systems are designed to meet the success criteria for purification by tangential filtration, including low hold-up volume, maximum volume concentration, and optimal product recovery for enhanced process performance.
Our Mobius® FlexReady Solution for TFF and Mobius® TFF 80 system provide a combination of single-use Flexware® assemblies and hardware specifically designed for efficient concentration and diafiltration of proteins. With installable filter area ranging from 0.5 to 20 m2, flow range from 2 to 80 L/min, and tank size from 50 to 500 L, our range of single-use TFF systems can adapt to your process needs from pre-clinical to manufacturing scale. Closed mode of operation is possible with specifically designed flowpath and equipment, allowing to reduce contamination risk and protect operators while increasing flexibility and efficiency. This family of equipment features:
The fully automated Cogent® Process-Scale TFF System is designed to separate and purify monoclonal antibodies, vaccines, plasma, and therapeutic proteins. It is ideally suited for both pilot and production scale applications, thereby supporting rapid scale-up from small- to large-scale operations. Other key system features include:
Our family of Cogent® Lab systems uses similar design, sensing technologies, and accessories as our manufacturing-scale equipment. With a homogeneous design and flow range from 20 to 6000 mL/min, our systems have been specifically created to simplify process development. The Cogent® Lab 150, 800, and 6000 systems are optimized for high product recovery and drainability, ensuring successful small-scale TFF operations.
Our systems are best suited for use with Pellicon® expendables, either in single-use (Pellicon® Capsule) or multi-use applications (Pellicon® 2 and 3). Holders may be included when purchasing a TFF system; please refer to the appropriate data sheet for details. We provide self-standing holders for filtration area from 88 cm² to 130 m² depending on expendables.
Options are available to increase the installed surface and run in single-pass mode.
Data Sheet: Mobius® TFF 80 System
Perf. Guide: Mobius® TFF 80 System
Spare Parts List: Mobius® TFF 80 System
Data Sheet: Mobius® FlexReady Solution for TFF
Performance Guide: Mobius® FlexReady Solution (TF2S) with Smart Flexware® Assemblies for TFF with Closed Enabled Configuration
Spec. Sheet: Mobius® FlexReady Solution with Smart Flexware® Assemblies for TFF
Spare Parts List: Mobius® FlexReady Solution
Data Sheet: Cogent® Process-scale Tangential Flow Filtration System
Many factors contribute to a TFF system design; this webinar explains how to optimize the TFF process parameters to achieve superior product quality, consistent and high product yield, high concentration, and reproducible process flux and time.
This webinar discusses how to evaluate retentate recycle tank performance and how an active retentate mixing step can best enable optimum performance of protein concentration / diafiltration in single-use systems.
This webinar discusses the implementation of closed processing for downstream applications and present the design and performance testing of a single-use manufacturing-scale tangential flow filtration system to be able to operate in both functionally and fully closed mode.
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