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Single Molecule Counting (SMC®) Technology

Originally developed by Singulex®, Inc., Single Molecule Counting (SMC®) technology with the SMCxPRO® platform enables researchers to measure femtogram levels of biomarkers and better understand the clinical relevance from healthy to disease. Learn more about SMC® technology, immunoassay kits, and how you can design your own custom assay to meet your critical research needs.

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Products

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Product Number
Product Description
Pricing
03-0078-00
SMC® Bead-Based Immunoassay Development Buffer Kit
03-0077-02
SMC® Capture Antibody Labeling Kit
02-0111-03
Erenna 10X System Buffer w/ Proclin
03-0076-02
SMC® Detection Antibody Labeling Kit
03-0188-00
SMC® Human Phospho-α-Synuclein (S129) High Sensitivity Immunoassay Kit
03-0184-00
SMC® Human Phospho-Tau (T181) High Sensitivity Immunoassay Kit
03-0154-00
SMC® Human cTNi High Sensitivity Kit, 1 kit sufficient for 96 wells, input: serum, plasma
03-0146-00
SMC® Amyloid Beta 42 High Sensitivity Kit, 1 kit sufficient for 96 wells, input: serum, plasma, cerebrospinal fluid (CSF)
03-0160-00
SMC® Human IL-1β High Sensitivity Kit, 1 kit sufficient for 96 wells, input: plasma, serum
03-0155-00
SMC® Human Interleukin 6 (IL-6) High Sensitivity Immunoassay Kit, The sensitivity of the Single Molecule Counting (SMC®) technology gives the SMC Human Interleukin 6 (IL-6) High Sensitivity Immunoassay Kit unparalleled performance in the quantification of IL-6 in human serum and plasma.
03-0186-00
SMC® Human IFN-α2 High Sensitivity Immunoassay Kit
03-0125-01
SMC® Mouse IL-17F Discovery Immunoassay Kit
03-0123-00
SMC® Mouse IL-17A Discovery Immunoassay Kit
03-0145-00
SMC® Amyloid Beta 1-40 High Sensitivity Immunoassay Kit
03-0185-00
SMC® Human Total Tau High Sensitivity Immunoassay Kit
03-0128-00
SMC® Plate-Based Immunoassay Development Kit
03-0163-00
SMC® Human TNFα High Sensitivity Kit, 1 kit sufficient for 96 wells, input: plasma, serum
03-0122-00
SMC® optimization kit, Bead-Based Assay Buffer Optimization Kit
03-0159-00
SMC® Human IL-17A High Sensitivity Kit, 1 kit sufficient for 96 wells, input: plasma, serum
03-0180-00
SMC® Human VEGF-A High Sensitivity Immunoassay Kit
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Digital Counting Improves Sensitivity and Dynamic Range

Providing maximum immunoassay performance while following a workflow similar to traditional ELISA technology, SMC® technology combines a unique assay elution step and robust digital counting to achieve improved signal-to-noise ratios over traditional immunoassay technologies. The SMC® technology thus provides enhanced quantification at both low and high levels of expression on one complete system. The SMCxPRO® instrument captures the sum of all digital events counted above the background threshold. The digital event algorithm of the SMCxPRO® instrument computes digital events across a spectrum of time series for a single standard. The digital counting of molecules thus improves the assay sensitivity and extends the assay dynamic range beyond what can be achieved with traditional methods.

Verification Criteria for SMC® Immunoassays

A comprehensive set of criteria evaluating ultimate performance are used to qualify verified SMC® immunoassays, including:

  • Lower limit of quantification
  • Inter- and intra-assay precision
  • Spike recovery
  • Dilutional linearity and parallelism

Request Info

Have questions about SMC® Technology, SMC® kits, or the SMCxPRO® platform? Request more infomation by filling out our form.

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Related Product Resources

Learn more about how SMC® technology can take your research to the next level by exploring the topics below.

SMC® Research Areas

Browse all the ways researchers are using SMC® technology including drug development, neuroscience, cardiotoxicity, immunology research, and more.

Browse Research Areas >

Why Choose SMC® Technology?

See why choosing ultrasensitive SMC® technology can help you take a deeper look at your research to discover even more.

See Why >

SMCxPRO® Platform

SMC® assays are run on the state-of-the-art SMCxPRO® detection instrument. Discover more about this ultrasensitive immunoassay platform.

Discover More >

Other SMC® Instrumentation

View info on ancillary kits and equipment for SMC® assays that help optimize your workflows.

View Equipment >

Custom Assay Services

Explore more about our Custom Assay Development & Innovation (CADI) services and request more info.

Explore Services >

Tips and Support for SMC® Products

Get tips and tricks for running SMC® assays straight from the experts.

Get Tips & Tricks >

Subscribe to Our Newsletter

Stay up to date on the latest immunoassay research trends and our newest product offerings by subscribing to our Analyte Update newsletter or explore our current immunoassay offerings in the Analyte Quarterly.

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