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Zijian Xiao et al.
PloS one, 9(7), e101251-e101251 (2014-07-02)
This study was designed to investigate whether telomerase was involved in the neuroprotective effect of curcumin and Cur1. Alzheimer's disease is a consequence of an imbalance between the generation and clearance of amyloid-beta peptide in the brain. In this study
Jia Xu et al.
PloS one, 9(5), e97906-e97906 (2014-05-17)
Typically, most nephropathies can be categorized as complex human diseases in which the cumulative effect of multiple minor genes, combined with environmental and lifestyle factors, determines the disease phenotype. Thus, multi-target drugs would be more likely to facilitate comprehensive renoprotection
Pramila Chaubey et al.
Expert opinion on drug delivery, 11(8), 1163-1181 (2014-05-31)
The study aims at formulation and optimization of macrophage-targeted curcumin-loaded mannosylated chitosan nanoparticles (Cur-MCNPs) of curcumin (CUR) to improve its therapeutic potential in the treatment of visceral leishmaniasis (VL). Response surface methodology (RSM) using central composite design was employed to
Wei-Hung Yang et al.
Biochimica et biophysica acta, 1840(12), 3483-3493 (2014-09-18)
Leptin, 16kDa product of obese gene, is adipocytokine playing critical role in regulation of body weight. In recent years, leptin is also defined as potent angiogenic factor involving in tumorigenesis, angiogenesis, and metastasis. However, it is unknown whether leptin regulates
Mi-Hsueh Tai et al.
Molecular nutrition & food research, 58(11), 2133-2145 (2014-08-29)
Curcumin has been demonstrated as having numerous desirable characteristics, such as antioxidant, anti-inflammatory, and antiatherogenic activities. We report the hypocholesterolemic effect and molecular mechanism of curcumin. We found that curcumin enhanced LDL receptor (LDLR) level on the cell surface, as
James N Jacob et al.
Natural product communications, 8(3), 359-362 (2013-05-18)
Curcumin, obtained from turmeric, has several biological properties to make it a desirable template for drug development. A lipophilic derivative of curcumin, diacetyl curcumin (DAC) and a hydrophilic derivative, diglutaryl curcumin (DGC) were synthesized and their in vivo analgesic and
Zhipeng Chen et al.
Food chemistry, 155, 81-86 (2014-03-07)
The results of TG/DTG when curcumin was used as the food colouring agent indicated that the processing temperature of the food should not exceed 190°C. The decomposition process of curcumin involved two stages. The results of Eα values, determined by
Debanjan Tewari et al.
Biochimica et biophysica acta, 1848(1 Pt A), 151-158 (2014-12-03)
Voltage dependent anion channel (VDAC) of mitochondria plays a crucial role in apoptosis. Human VDAC-1, reconstituted in planar lipid bilayer showed reduced conductance when treated with curcumin. Curcumin interacts with residues in the α helical N-terminus of VDAC and in
Kahkashan Rashid et al.
Biochimica et biophysica acta, 1852(1), 70-82 (2014-12-03)
In the present study, we sought to explore whether curcumin plays any beneficial role against STZ induced testicular abnormalities in diabetic rats, and if so, what possible mechanism it utilizes to provide protection. Exposure to STZ (50mg/kg body weight, i.p.
Michal Heger et al.
Pharmacological reviews, 66(1), 222-307 (2013-12-26)
This review addresses the oncopharmacological properties of curcumin at the molecular level. First, the interactions between curcumin and its molecular targets are addressed on the basis of curcumin's distinct chemical properties, which include H-bond donating and accepting capacity of the
Abo Bakr Abdel Shakor et al.
Biochimica et biophysica acta, 1841(12), 1672-1682 (2014-09-23)
Most anti-cancer agents induce apoptosis, however, a development of multidrug resistance in cancer cells and defects in apoptosis contribute often to treatment failure. Here, the mechanism of curcumin-induced apoptosis was investigated in human leukemia HL60 cells and their HL60/VCR multidrug-resistant
Mohammed Anwar et al.
International journal of pharmaceutics, 468(1-2), 158-164 (2014-04-22)
Nano-sized curcumin-loaded super-paramagnetic iron oxide nanoparticles (CUR-OA-SPIONs) were synthesized chemically by co-precipitation method using oleic acid as a stabilizer and Myrj 52 as a surfactant. The synthesized nanoparticles were characterized for their shape, size, surface morphology, electrokinetic potential, magnetic properties
Fan Meng et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 71, 12-24 (2015-02-18)
Curcumin (CUR) was used as a poorly soluble drug whereas polyvinyl pyrrolidone K90 (PVP), Eudragit EPO (EPO), hydroxypropyl methylcellulose E5 (HPMC) and polyethylene glycol 8000 (PEG) were used as hydrophilic polymers. CUR polymer miscibility was evaluated by solubility parameter, melting
Huijin Fan et al.
Targeted oncology, 9(3), 279-286 (2013-07-04)
Fatty acid synthase (FAS) is highly expressed in many kinds of human cancers, including liver cancer. Curcumin is the major active ingredient of Curcuma longa and has long been used to treat a variety of maladies. In the present study
Angela Storka et al.
Anticancer research, 33(9), 3629-3634 (2013-09-12)
The anti-inflammatory and antiproliferative agent curcumin has poor oral bioavailability and solubility in plasma. Liposomal formulations have therefore been developed, but the toxicity of these preparations is not yet established. We investigated the influence of free and liposomally formulated curcumin
Haiqiang Cao et al.
Molecular pharmaceutics, 12(3), 922-931 (2015-01-27)
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Herein, we first reported the codelivery of sorafenib and curcumin by directed self-assembled nanoparticles (SCN) to enhance the therapeutic effect on HCC. SCN was formed by
Sarvjeet Singh et al.
Anti-cancer agents in medicinal chemistry, 6(3), 259-270 (2006-05-23)
Curcumin, a natural component of the rhizome of curcuma longa has emerged as one of the most powerful chemopreventive and anticancer agents. Its biological effects range from antioxidant, anti-inflammatory to inhibition of angiogenesis and is also shown to possess specific
Prakash Ramalingam et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 969, 101-108 (2014-08-30)
Curcumin is a well-known multitherapeutic agent widely employed in neurodegenerative disorders and cancer. A selective, fast, and sensitive method employing liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was developed and validated for the simultaneous determination of curcumin in mouse
Yingcong Yu et al.
Metabolic brain disease, 30(1), 47-55 (2014-05-09)
Irritable bowel syndrome (IBS) is induced by dysfunction of central nervous and peripheral intestinal systems, which affects an estimated 10-15% population worldwide annually. Stress-related psychiatric disorders including depression and anxiety are often comorbid with gastrointestinal function disorder, such as IBS.
Marichamy Rajasekaran et al.
Journal of nanoscience and nanotechnology, 14(7), 4874-4879 (2014-04-25)
Nanostructured phyto-drugs such as curcumin and quercetin were prepared by simple sonochemical method and studied for their bio-activities. FT-IR spectra indicate that the chemical structures of these nanostructured drugs are identical with their commercially available microcrystalline counterparts. Scanning Electron Microscopic
Daijiro Yanagisawa et al.
Neurobiology of aging, 36(1), 201-210 (2014-09-03)
Recent evidence supports the amyloid cascade hypothesis that a pathological change of amyloid β (Aβ) in the brain is an initiating event in Alzheimer's disease (AD). Accordingly, modulating the abnormal Aβ aggregation is considered a potential therapeutic target in AD.
Tao Zhou et al.
PloS one, 9(9), e107876-e107876 (2014-10-01)
Curcumin, a spice component as well as a traditional Asian medicine, has been reported to inhibit proliferation of a variety of cancer cells but is limited in application due to its low potency and bioavailability. Here, we have assessed the
Mona Fouad Mahmoud et al.
Pharmaceutical biology, 52(8), 972-977 (2014-03-13)
Consumption of high fructose is associated with metabolic abnormalities, insulin resistance, and hypertension. It is not known whether this hypertensive effect of fructose is related to metabolic abnormalities or due to the direct effect of fructose on blood vessels. Here
Ian M Williams et al.
Neurobiology of disease, 67, 9-17 (2014-03-19)
Niemann-Pick disease type C (NPC) is a neurodegenerative lysosomal storage disorder characterised by the storage of multiple lipids, reduced lysosomal calcium levels, impaired late endosome:lysosome fusion and neuroinflammation. NPC is caused by mutations in either of the two genes, NPC1
Tzu-Hua Lin et al.
The Journal of biological chemistry, 288(27), 19359-19369 (2013-05-21)
Despite the fact that androgen deprivation therapy (ADT) can effectively reduce prostate cancer (PCa) size, its effect on PCa metastasis remains unclear. We examined the existing data on PCa patients treated with ADT plus anti-androgens to analyze ADT effects on
Bopaiah Cheppudira et al.
Expert opinion on investigational drugs, 22(10), 1295-1303 (2013-08-02)
Managing burn injury-associated pain and wounds is a major unresolved clinical problem. Opioids, nonsteroidal antiinflammatory drugs (NSAIDs), antidepressants and anticonvulsants remain the most common forms of analgesic therapy to treat burn patients. However, prolonged treatment with these drugs leads to
Mingxiang Ye et al.
Cancer letters, 357(1), 196-205 (2014-12-03)
Curcumin has attracted increasing interest as an anti-cancer drug for decades. The mechanisms of action involve multiple cancer-related signaling pathways. Recent studies highlighted curcumin has epigenetic regulatory effects on miRNA in cancers. In the present study, we demonstrated the proapoptotic
Investigations of curcumin and resveratrol on neurite outgrowth: perspectives on spinal muscular atrophy.
Bora-Tatar G, Erdem-Yurter H, et al.
BioMed Research International, 2014, 709108-709108 (2014)
Elena Creţu et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 116(4), 1223-1229 (2013-05-25)
Nowadays cancer is still a major public health issue. Despite all the progresses made in cancer prevention, diagnosis and treatment, mortality by cancer is on the second place after the one caused by cardiovascular diseases. The high mortality and the
Maurizio Vitadello et al.
The Journal of physiology, 592(12), 2637-2652 (2014-04-09)
Antioxidant administration aimed to antagonize the development and progression of disuse muscle atrophy provided controversial results. Here we investigated the effects of curcumin, a vegetal polyphenol with pleiotropic biological activity, because of its ability to upregulate glucose-regulated protein 94 kDa
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