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K M D'Souza et al.
American journal of physiology. Heart and circulatory physiology, 309(8), H1346-H1353 (2015-09-16)
Transient angiotensin-converting enzyme (ACE) inhibition induces persistent changes that protect against future nitric oxide synthase (NOS) inhibitor-induced cardiac fibrosis and inflammation. Given the role of fibroblasts in mediating these effects, the present study investigates whether prior ACE inhibition produced persistent
Yanbo Wei et al.
The Analyst, 140(4), 1298-1305 (2015-01-09)
A very uniform 2,5-dihydroxybenzoic acid (DHB) layer was for the first time constructed and used as a matrix for matrix-assisted laser desorption ionization Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR MS) for quickly exploring the changes in lipids within
Yukiko Ohwaki et al.
Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence, 48(2), 126-144 (2013-07-03)
The goal of the study was to examine the status, Stages of Change and motivation, alcohol dependence, and harmful use of alcohol in gastroenterological inpatients. We interviewed 141 gastroenterological inpatients and analyzed their medical charts. The interviews used the Alcohol
Zhen Long et al.
Analytica chimica acta, 872, 77-83 (2015-04-22)
This study investigated the influence of organic sample solvents on separation efficiency of basic compounds under strong cation exchange (SCX) mode. The mixtures of acidic aqueous solution and organic solvent such as acetonitrile, ethanol, methanol and dimethyl sulfoxide (DMSO) were
Xing Xiao et al.
Pain, 156(4), 597-608 (2015-03-20)
Transient receptor potential vanilloid 1 (TRPV1) receptors are expressed in nociceptive neurons of rat dorsal root ganglions (DRGs) and mediate inflammatory pain. Nonspecific inhibition of protein-tyrosine phosphatases (PTPs) increases the tyrosine phosphorylation of TRPV1 and sensitizes TRPV1. However, less is
Benjamin D Sachs et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(8), 2557-2562 (2015-02-13)
Brain serotonin (5-HT) deficiency and exposure to psychosocial stress have both been implicated in the etiology of depression and anxiety disorders, but whether 5-HT deficiency influences susceptibility to depression- and anxiety-like phenotypes induced by psychosocial stress has not been formally
Theodore R Hobbs et al.
Journal of the American Association for Laboratory Animal Science : JAALAS, 54(6), 687-693 (2015-12-04)
Most biomedical facilities that use rhesus macaques (Macaca mulatta) limit the amount of blood that may be collected for experimental purposes. These limits typically are expressed as a percentage of blood volume (BV), estimated by using a fixed ratio of
Manuela Eisenhardt et al.
Alcoholism, clinical and experimental research, 39(4), 752-762 (2015-04-04)
One of the most commonly used approaches to induce ethanol (EtOH) dependence in rodents is EtOH vapor inhalation. This procedure requires the co-administration of pyrazole-an inhibitor of the alcohol dehydrogenase-to obtain stable blood EtOH concentrations (BECs) during the entire induction
Rishil J Kathawala et al.
Oncotarget, 6(1), 510-521 (2014-11-18)
Paclitaxel exhibits clinical activity against a wide variety of solid tumors. However, resistance to paclitaxel significantly attenuates the response to chemotherapy. The ABC transporter subfamily C member 10 (ABCC10), also known as multi-drug resistance protein 7 (MRP7) efflux transporter, is
Jérémy A Ferreira Barbosa et al.
Virology journal, 12, 188-188 (2015-11-19)
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens in the swine industry and causes important economic losses. No effective antiviral drugs against it are commercially available. We recently reported that the culture supernatant of
Hesheng Liu et al.
Journal of natural medicines, 68(3), 521-529 (2014-04-10)
To evaluate the beneficial effects of Chinese bayberry (Myrica rubra Sieb. et Zucc.) flavonoid extract (CBFE) on chronic alcohol-induced liver oxidative injury in mice, experimental mice were pretreated with different doses of CBFE (50-200 mg/kg) for 4 weeks by gavage feeding. Biochemical
Eunice Molinar-Toribio et al.
PloS one, 9(8), e104637-e104637 (2014-08-15)
SHROB rats have been suggested as a model for metabolic syndrome (MetS) as a situation prior to the onset of CVD or type-2 diabetes, but information on descriptive biochemical parameters for this model is limited. Here, we extensively evaluate parameters
Koichi Sakakura et al.
Cancer science, 106(1), 1-8 (2014-10-24)
The immunological significance of autophagy in the tumor microenvironment remains unclear. To explore the relationship between autophagy and anti-tumor immune responses, we investigated the expression of autophagy-related proteins and infiltration of immune cells using immunohistochemistry (IHC). The expression of three
Bum-Ho Bin et al.
PloS one, 9(8), e105965-e105965 (2014-08-30)
Many tissues of the human body encounter hyperosmotic stress. The effect of extracellular osmotic changes on melanin production has not yet been elucidated. In this study, we determined that hyperosmotic stress induced by organic osmolytes results in reduced melanin production
Quoc-Chon Le et al.
Colloids and surfaces. B, Biointerfaces, 123, 150-157 (2014-09-23)
A systematic study was carried out on monolayer films and lipid vesicles to elucidate the interactions between membrane lipids and commercial particles of titanium dioxide TiO2 (TiO2-P25). Pressure-area isotherms of lipids at various pH values were recorded on a Langmuir
J H Lee et al.
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 19(2), 250-253 (2013-05-23)
Multiple treatment options have been introduced for the treatment of sacral tumoral bone pain. These options include pre-operative sacral embolization, percutaneous cryoablation, alcohol ablation, and sacroplasty. We intend to show that in the correct clinical scenario, a combination of the
Sebastian Schmidt et al.
Oncotarget, 5(13), 4799-4810 (2014-07-13)
Mechanisms underlying therapy resistance of tumor cells include protein kinase Akt. Putative Akt targets include store-operated Ca(2+)-entry (SOCE) accomplished by pore forming ion channel unit Orai1 and its regulator STIM1. We explored whether therapy resistant (A2780cis) differ from therapy sensitive
Adriano Valentin-Silva et al.
American journal of botany, 102(4), 626-633 (2015-04-17)
Dichogamy is a common characteristic among angiosperms, including Piper species. In this genus, the tiny flowers are morphologically similar and have an asynchronous stamen development. However, there is no information on the duration of stigma receptivity and whether it overlaps
Tiffany A Wills et al.
Cold Spring Harbor perspectives in medicine, 3(4), a012161-a012161 (2013-02-22)
The extended amygdala is a series of interconnected, embryologically similar series of nuclei in the brain that are thought to play key roles in aspects of alcohol dependence, specifically in stress-induced increases in alcohol-seeking behaviors. Plasticity of excitatory transmission in
Anshita Rai et al.
Developmental biology, 398(1), 110-119 (2014-12-17)
The maternal blood space in the mouse placenta is lined not by endothelial cells but rather by various subtypes of trophoblast giant cells (TGCs), defined by their location and different patterns of gene expression. While TGCs invade the spiral arteries
Scott A Rankin et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 244(1), 69-85 (2014-08-27)
Respiratory system development is regulated by a complex series of endoderm-mesoderm interactions that are not fully understood. Recently Xenopus has emerged as an alternative model to investigate early respiratory system development, but the extent to which the morphogenesis and molecular
Cem Kuscu et al.
Nature biotechnology, 32(7), 677-683 (2014-05-20)
RNA-guided genome editing with the CRISPR-Cas9 system has great potential for basic and clinical research, but the determinants of targeting specificity and the extent of off-target cleavage remain insufficiently understood. Using chromatin immunoprecipitation and high-throughput sequencing (ChIP-seq), we mapped genome-wide
Vez Repunte-Canonigo et al.
Addiction biology, 19(5), 791-799 (2013-03-02)
We have investigated the expression of chromatin-regulating genes in the prefrontal cortex and in the shell subdivision of the nucleus accumbens during protracted withdrawal in mice with increased ethanol drinking after chronic intermittent ethanol (CIE) vapor exposure and in mice
Amit Ganguly et al.
Indian journal of experimental biology, 51(7), 556-566 (2013-08-01)
An efficient conversion of lignocellulose into fermentable sugars is a key step in producing bioethanol in a cost effective and eco-friendly manner. Alternative source like water hyacinth biomass (WHB) (Eichhornia crassipes) may be used as a supplement for the routine
Olga Shakhova et al.
PLoS genetics, 11(1), e1004877-e1004877 (2015-01-30)
Melanoma is the most fatal skin cancer, but the etiology of this devastating disease is still poorly understood. Recently, the transcription factor Sox10 has been shown to promote both melanoma initiation and progression. Reducing SOX10 expression levels in human melanoma
Renee C Gentzel et al.
Neuropharmacology, 99, 256-263 (2015-06-06)
Phosphodiesterase 10A (PDE10A) has garnered attention as a potential therapeutic target for schizophrenia due to its prominent striatal expression and ability to modulate striatal signaling. The present study used the selective PDE10A inhibitor MP-10 and the dopamine D2 antagonist haloperidol
Yu Gao et al.
Stem cells (Dayton, Ohio), 33(5), 1618-1629 (2015-02-03)
In both the embryonic and adult brain, a critical step in neurogenesis is neuronal maturation. Deficiency of MeCP2 leads to Rett syndrome, a severe neurodevelopmental disorder. We have previously shown that MeCP2 plays critical roles in the maturation step of
Aaron W Puri et al.
Applied and environmental microbiology, 81(5), 1775-1781 (2014-12-31)
Aerobic methanotrophs oxidize methane at ambient temperatures and pressures and are therefore attractive systems for methane-based bioconversions. In this work, we developed and validated genetic tools for Methylomicrobium buryatense, a haloalkaliphilic gammaproteobacterial (type I) methanotroph. M. buryatense was isolated directly
Ana M Romero et al.
Neurotoxicity research, 27(1), 43-54 (2014-07-16)
The specific traffic of the membrane components in neurons is a major requirement to establish and maintain neuronal domains-the axonal and the somatodendritic domains-and their polarized morphology. Unlike axons, dendrites contain membranous organelles, which are involved in the secretory pathway
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