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Huijin Fan et al.
Targeted oncology, 9(3), 279-286 (2013-07-04)
Fatty acid synthase (FAS) is highly expressed in many kinds of human cancers, including liver cancer. Curcumin is the major active ingredient of Curcuma longa and has long been used to treat a variety of maladies. In the present study
Jeffrey M Witkin et al.
CNS & neurological disorders drug targets, 12(4), 487-497 (2013-04-12)
The root extract, curcumin (diferuloylmethane), is a constituent of the ancient herbal medicine Jiawei-Xiaoyaosan that has been used for dyspepsia, stress, and mood disorders. Curcumin engenders a diverse profile of biological actions that result in changes in oxidative stress, inflammation
Fan Meng et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 71, 12-24 (2015-02-18)
Curcumin (CUR) was used as a poorly soluble drug whereas polyvinyl pyrrolidone K90 (PVP), Eudragit EPO (EPO), hydroxypropyl methylcellulose E5 (HPMC) and polyethylene glycol 8000 (PEG) were used as hydrophilic polymers. CUR polymer miscibility was evaluated by solubility parameter, melting
Wei-Hung Yang et al.
Biochimica et biophysica acta, 1840(12), 3483-3493 (2014-09-18)
Leptin, 16kDa product of obese gene, is adipocytokine playing critical role in regulation of body weight. In recent years, leptin is also defined as potent angiogenic factor involving in tumorigenesis, angiogenesis, and metastasis. However, it is unknown whether leptin regulates
Jia Xu et al.
PloS one, 9(5), e97906-e97906 (2014-05-17)
Typically, most nephropathies can be categorized as complex human diseases in which the cumulative effect of multiple minor genes, combined with environmental and lifestyle factors, determines the disease phenotype. Thus, multi-target drugs would be more likely to facilitate comprehensive renoprotection
Mi-Hsueh Tai et al.
Molecular nutrition & food research, 58(11), 2133-2145 (2014-08-29)
Curcumin has been demonstrated as having numerous desirable characteristics, such as antioxidant, anti-inflammatory, and antiatherogenic activities. We report the hypocholesterolemic effect and molecular mechanism of curcumin. We found that curcumin enhanced LDL receptor (LDLR) level on the cell surface, as
Zijian Xiao et al.
PloS one, 9(7), e101251-e101251 (2014-07-02)
This study was designed to investigate whether telomerase was involved in the neuroprotective effect of curcumin and Cur1. Alzheimer's disease is a consequence of an imbalance between the generation and clearance of amyloid-beta peptide in the brain. In this study
Yingcong Yu et al.
Metabolic brain disease, 30(1), 47-55 (2014-05-09)
Irritable bowel syndrome (IBS) is induced by dysfunction of central nervous and peripheral intestinal systems, which affects an estimated 10-15% population worldwide annually. Stress-related psychiatric disorders including depression and anxiety are often comorbid with gastrointestinal function disorder, such as IBS.
Mingxiang Ye et al.
Cancer letters, 357(1), 196-205 (2014-12-03)
Curcumin has attracted increasing interest as an anti-cancer drug for decades. The mechanisms of action involve multiple cancer-related signaling pathways. Recent studies highlighted curcumin has epigenetic regulatory effects on miRNA in cancers. In the present study, we demonstrated the proapoptotic
Bopaiah Cheppudira et al.
Expert opinion on investigational drugs, 22(10), 1295-1303 (2013-08-02)
Managing burn injury-associated pain and wounds is a major unresolved clinical problem. Opioids, nonsteroidal antiinflammatory drugs (NSAIDs), antidepressants and anticonvulsants remain the most common forms of analgesic therapy to treat burn patients. However, prolonged treatment with these drugs leads to
Kunal Jain et al.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 17(5), 579-591 (2013-08-03)
Cerebral malaria is the most severe and rapidly fatal neurological complication of Plasmodium falciparum infection and responsible for more than two million deaths annually. The current therapy is inadequate in terms of reducing mortality or post-treatment symptoms such as neurological
Mona Fouad Mahmoud et al.
Pharmaceutical biology, 52(8), 972-977 (2014-03-13)
Consumption of high fructose is associated with metabolic abnormalities, insulin resistance, and hypertension. It is not known whether this hypertensive effect of fructose is related to metabolic abnormalities or due to the direct effect of fructose on blood vessels. Here
Tao Zhou et al.
PloS one, 9(9), e107876-e107876 (2014-10-01)
Curcumin, a spice component as well as a traditional Asian medicine, has been reported to inhibit proliferation of a variety of cancer cells but is limited in application due to its low potency and bioavailability. Here, we have assessed the
Thitita Unahabhokha et al.
Pharmaceutical biology, 53(3), 457-463 (2014-10-22)
Keloid is an excessive dermal scar occurring in response to skin injuries. Several therapeutic strategies have been proposed to ease the aggressiveness of keloid scarring. Even though the principle mechanism underlying the disease propagation still remains unidentified, several signaling pathways
Khajeelak Chiablaem et al.
Anticancer research, 34(4), 1857-1864 (2014-04-03)
Vasculogenic mimicry (VM) refers to the process in which highly invasive cancer cells mimic endothelial cells by forming blood channels. In the present study, we investigated the effect of curcumin, a natural product from turmeric, on VM of SK-Hep-1 human
Ian M Williams et al.
Neurobiology of disease, 67, 9-17 (2014-03-19)
Niemann-Pick disease type C (NPC) is a neurodegenerative lysosomal storage disorder characterised by the storage of multiple lipids, reduced lysosomal calcium levels, impaired late endosome:lysosome fusion and neuroinflammation. NPC is caused by mutations in either of the two genes, NPC1
Maurizio Vitadello et al.
The Journal of physiology, 592(12), 2637-2652 (2014-04-09)
Antioxidant administration aimed to antagonize the development and progression of disuse muscle atrophy provided controversial results. Here we investigated the effects of curcumin, a vegetal polyphenol with pleiotropic biological activity, because of its ability to upregulate glucose-regulated protein 94 kDa
Seyung S Chung et al.
Anticancer research, 35(1), 39-46 (2015-01-01)
The cancer stem cell (CSC) model postulates the existence of a small proportion of cancer cells capable of sustaining tumor formation, self-renewal and differentiation. Signal Transducer and Activator of Transcription 3 (STAT3) signaling is known to be selectively activated in
Prakash Ramalingam et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 969, 101-108 (2014-08-30)
Curcumin is a well-known multitherapeutic agent widely employed in neurodegenerative disorders and cancer. A selective, fast, and sensitive method employing liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was developed and validated for the simultaneous determination of curcumin in mouse
Mohammed Anwar et al.
International journal of pharmaceutics, 468(1-2), 158-164 (2014-04-22)
Nano-sized curcumin-loaded super-paramagnetic iron oxide nanoparticles (CUR-OA-SPIONs) were synthesized chemically by co-precipitation method using oleic acid as a stabilizer and Myrj 52 as a surfactant. The synthesized nanoparticles were characterized for their shape, size, surface morphology, electrokinetic potential, magnetic properties
Abo Bakr Abdel Shakor et al.
Biochimica et biophysica acta, 1841(12), 1672-1682 (2014-09-23)
Most anti-cancer agents induce apoptosis, however, a development of multidrug resistance in cancer cells and defects in apoptosis contribute often to treatment failure. Here, the mechanism of curcumin-induced apoptosis was investigated in human leukemia HL60 cells and their HL60/VCR multidrug-resistant
Pramila Chaubey et al.
Expert opinion on drug delivery, 11(8), 1163-1181 (2014-05-31)
The study aims at formulation and optimization of macrophage-targeted curcumin-loaded mannosylated chitosan nanoparticles (Cur-MCNPs) of curcumin (CUR) to improve its therapeutic potential in the treatment of visceral leishmaniasis (VL). Response surface methodology (RSM) using central composite design was employed to
Fangyuan Chen et al.
Journal of cardiovascular pharmacology, 63(6), 544-552 (2014-04-09)
This study aimed to investigate the effects of curcumin on macrophages polarization and possible mechanism involved, and to analyze the molecular basis of its antiatherosclerosis activity. RAW264.7 macrophages (M0) and M1 macrophages were treated with curcumin at 0, 6.25, 12.5
Deepak Yadav et al.
International journal of pharmaceutics, 477(1-2), 564-577 (2014-12-03)
The present work aims to investigate applicability of antisolvent precipitation method for preparation of nanosized curcumin and to control their characteristics by determining the influence of process and solvents on solid-state properties of curcumin nanoparticles. Effects of different experimental parameters
Lei Chong et al.
Inflammation, 37(5), 1476-1485 (2014-04-08)
Curcumin, a natural product derived from the plant Curcuma longa, has been found to have anti-inflammatory, antineoplastic and antifibrosis effects. It has been reported that curcumin attenuates allergic airway inflammation in mice through inhibiting NF-κB and its downstream transcription factor
Youcai Tang et al.
Laboratory investigation; a journal of technical methods and pathology, 94(5), 503-516 (2014-03-13)
Non-alcoholic steatohepatitis (NASH) is a major risk factor for hepatic fibrogenesis. NASH is often found in diabetic patients with hyperglycemia. Hyperglycemia induces non-enzymatic glycation of proteins, yielding advanced glycation end-products (AGEs). Effects of AGEs are mainly mediated by two categories
Yildiz Öner-İyidoğan et al.
Canadian journal of physiology and pharmacology, 92(10), 805-812 (2014-09-12)
High fat diet (HFD) is associated with oxidative stress induced fatty liver. Curcumin, an extract of Curcuma longa, has been shown to possess potent antioxidant and hypolipidemic properties. In this study, we investigated the effect of curcumin treatment on hepatic
R Afrin et al.
Free radical research, 49(3), 279-289 (2014-12-24)
We investigated the effect of curcumin on liver injury in diabetic rats induced by streptozotocin (STZ) through modulation of endoplasmic reticulum stress (ERS) and unfolded protein response (UPR). Experimental diabetes was induced by a single intraperitoneal injection of STZ (55
Feng Xu et al.
The clinical respiratory journal, 9(1), 87-97 (2014-01-28)
Curcumin has remarkable anti-inflammatory and antioxidant properties. However, its effects on bacterium-induced acute lung injury (ALI) are not fully understood. To investigate the protective effects of curcumin on a mouse model of S. aureus-induced ALI. Mice were pretreated with intraperitoneal injection
Rana Tarzemany et al.
PloS one, 10(1), e0115524-e0115524 (2015-01-15)
Connexins (C×s) are a family of transmembrane proteins that form hemichannels and gap junctions (GJs) on the cell membranes, and transfer small signaling molecules between the cytoplasm and extracellular space and between connecting cells, respectively. Among C×s, suppressing C×43 expression
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