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E Ortmann et al.
Journal of thrombosis and haemostasis : JTH, 13(7), 1207-1216 (2015-04-24)
Viscoelastic point-of-care tests such as thromboelastography (TEG) and rotational thromboelastometry (ROTEM) are increasingly used to guide hemostatic therapy after cardiac surgery. The aim of this study was to assess their clinical utility during cardiopulmonary bypass to predict postbypass coagulation status
Matteo Cargnello et al.
Journal of the American Chemical Society, 137(21), 6906-6911 (2015-05-12)
A simple yet efficient method to remove organic ligands from supported nanocrystals is reported for activating uniform catalysts prepared by colloidal synthesis procedures. The method relies on a fast thermal treatment in which ligands are quickly removed in air, before
Michael Eck et al.
Physical chemistry chemical physics : PCCP, 16(24), 12251-12260 (2014-05-14)
We present a significant efficiency enhancement of hybrid bulk heterojunction solar cells by utilizing CdSe quantum dots attached to reduced graphene oxide (rGO) as the electron accepting phase, blended with the PCPDTBT polymer. The quantum dot attachment to rGO was
Tonye Telema Wokoma et al.
The journal of family planning and reproductive health care, 41(3), 186-192 (2014-06-12)
To determine the main reasons for termination of pregnancy (TOP) requests in a UK city. A survey requesting reasons for a pregnancy termination from women attending a TOP clinic. A TOP pre-assessment clinic in Hull and East Yorkshire Hospitals, UK.
Anke Loregger et al.
Science signaling, 8(393), ra90-ra90 (2015-09-10)
Given its fundamental role in development and cancer, the Wnt-β-catenin signaling pathway is tightly controlled at multiple levels. RING finger protein 43 (RNF43) is an E3 ubiquitin ligase originally found in stem cells and proposed to inhibit Wnt signaling by
Ward van der Stam et al.
ACS nano, 9(11), 11430-11438 (2015-10-10)
The direct synthesis of heteronanocrystals (HNCs) combining different ternary semiconductors is challenging and has not yet been successful. Here, we report a sequential topotactic cation exchange (CE) pathway that yields CuInSe2/CuInS2 dot core/rod shell nanorods with near-infrared luminescence. In our
Lucas A Lane et al.
The journal of physical chemistry. B, 118(49), 14140-14147 (2014-08-27)
Quantum dots (QDs) offer distinct advantages over organic dyes and fluorescent proteins for biological imaging applications because of their brightness, photostability, and tunability. However, a major limitation is that single QDs emit fluorescent light in an intermittent on-and-off fashion called
Bjoern Traenkle et al.
Molecular & cellular proteomics : MCP, 14(3), 707-723 (2015-01-18)
β-catenin is the key component of the canonical Wnt pathway and plays a crucial role in a multitude of developmental and homeostatic processes. The different tasks of β-catenin are orchestrated by its subcellular localization and participation in multiprotein complexes. To
Kim De Nolf et al.
Journal of the American Chemical Society, 137(7), 2495-2505 (2015-01-30)
We investigate the relation between the chain length of ligands used and the size of the nanocrystals formed in the hot injection synthesis. With two different CdSe nanocrystal syntheses, we consistently find that longer chain carboxylic acids result in smaller
Dong-Hui Shin et al.
Oncotarget, 6(19), 17276-17290 (2015-05-06)
Inhibitor of differentiation/DNA binding (Id)1 is a crucial regulator of mammary development and breast cancer progression. However, its effect on stemness and tumorigenesis in mammary epithelial cells remains undefined. Herein, we demonstrate that Id1 induces mammary tumorigenesis by increasing normal
Sandeep Ghosh et al.
ACS nano, 9(8), 8537-8546 (2015-07-24)
We report on pyramid-shaped wurtzite cadmium selenide (CdSe) nanocrystals (NCs), synthesized by hot injection in the presence of chloride ions as shape-directing agents, exhibiting reversed crystal polarity compared to former reports. Advanced transmission electron microscopy (TEM) techniques (image-corrected high-resolution TEM
Neha Arora et al.
Physical chemistry chemical physics : PCCP, 16(23), 11381-11389 (2014-05-07)
Here we present digestive ripening facilitated interatomic diffusion for the phase controlled synthesis of homogeneous intermetallic nanocrystals of Au-Sn system. Au and Sn metal nanoparticles synthesized by a solvated metal atom dispersion (SMAD) method are employed as precursors for the
Junfeng Shi et al.
Biological & pharmaceutical bulletin, 38(9), 1345-1351 (2015-09-04)
Protein kinase CK2 ("casein kinase II") is a protein serine/threonine kinase that plays critical roles in biological processes such as cell growth, cell cycle progression, and apoptosis. So far, we have identified that one catalytic isozyme of CK2, CK2α, is
Yusuke Takahashi et al.
FEBS letters, 589(10), 1143-1149 (2015-03-23)
Aberrant activation of Wnt signaling contributes to ischemia-induced retinal neovascularization in oxygen-induced retinopathy (OIR), although the underlying mechanism is so far unclear. Here, we show that microRNA-184 (miR-184) is significantly down-regulated in the retina of OIR mice, and miR-184 negatively
De-Qing Liu et al.
Scientific reports, 5, 11955-11955 (2015-07-08)
Aberrant expression of receptor interacting protein kinase 4 (RIPK4), a crucial regulatory protein of Wnt/β-catenin signaling, has recently been reported to be involved in several cancers. Here, we report the potential clinical implication and biological functions of RIPK4 in cervical
Weixin Wang et al.
Journal of agricultural and food chemistry, 63(43), 9488-9495 (2015-10-13)
The objective of this study was to investigate the ability of resveratrol and hesperetin to scavenge acrolein at pH 7.4 and 37 °C. About 6.4 or 5.2% of acrolein remained after reaction with resveratrol or hesperetin for 12 h at
Erik J Sheets et al.
Nanoscale, 7(45), 19317-19323 (2015-11-05)
The solution-based synthesis of nanoscale earth-abundant semiconductors has the potential to unlock simple, scalable, and tunable material processes which currently constrain development of novel compounds for alternative energy devices. One such promising semiconductor is zinc tin phosphide (ZnSnP2). We report
Mona Rafipoor et al.
Langmuir : the ACS journal of surfaces and colloids, 31(34), 9441-9447 (2015-08-12)
We investigate clustered CdSe/CdS quantum dots/quantum rods, ranging from single to multiple encapsulated rods within amphiphilic diblock copolymer micelles, by time-resolved optical spectroscopy. The effect of the clustering and the cluster size on the optical properties is addressed. The clusters
Armando Tripodi et al.
Clinical chemistry and laboratory medicine, 53(2), 265-273 (2014-08-26)
Apixaban is a newly developed direct oral anticoagulant targeting activated factor X (FXa). The degree of interference of apixaban with coagulation parameters has not been thoroughly investigated. Increasing amounts of apixaban were added to aliquots of a pooled normal plasma
Jewon Yoo et al.
Advanced materials (Deerfield Beach, Fla.), 27(10), 1712-1717 (2015-01-24)
A simple direct-writing technique can be used to fabricate a stretchable UV-vis-NIR nanowire photodetector (NWPD) consisting of PbS quantum dot (QD)-poly(3-hexylthiopehene) (P3HT) hybrid NWs. The hybrid NWPD shows superior sensitivity and response speed in the UV-vis to NIR range. The
Sophie Carenco et al.
Small (Weinheim an der Bergstrasse, Germany), 11(25), 3045-3053 (2015-03-03)
Bimetallic nanoparticle (NP) catalysts are interesting for the development of selective catalysts in reactions such as the reduction of CO2 by H2 to form hydrocarbons. Here the synthesis of Ni-Co NPs is studied, and the morphological and structural changes resulting
Martin S Engler et al.
Analytical chemistry, 87(10), 5223-5231 (2015-04-18)
The accurate characterization of synthetic polymer sequences represents a major challenge in polymer science. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is frequently used for the characterization of copolymer samples. We present the COCONUT software for estimating the composition
Chengquan Lu et al.
Toxicological sciences : an official journal of the Society of Toxicology, 147(2), 588-606 (2015-07-23)
Household pesticide exposure during pregnancy has been associated with a more than 2-fold increased risk in infant leukemia, and chlorpyrifos (CPF) is among the most frequently applied insecticides. During early fetal development, liver is a hematopoietic organ with majority of
Lamia Nahar et al.
ACS nano, 9(10), 9810-9821 (2015-09-22)
Hybrid nanomaterials composed of metal-semiconductor components exhibit unique properties in comparison to their individual counterparts, making them of great interest for optoelectronic applications. Theoretical and experimental studies suggest that interfacial interactions of individual components are of paramount importance to produce
Jun Chen et al.
Journal of nanobiotechnology, 13, 76-76 (2015-10-30)
X-ray computed tomography (CT) imaging can be used to reveal the three-dimensional structure of deep tissue with high spatial resolution. However, it cannot reveal molecular or cellular changes, and has great limitations in terms of specificity and sensitivity. Fluorescence imaging
Machteld M Tiemessen et al.
Journal of immunology (Baltimore, Md. : 1950), 193(11), 5480-5487 (2014-10-31)
The Wnt-responsive transcription factor T cell factor 1 (Tcf1) is well known for its role in thymic T cell development and the formation of memory CD8(+) T cells. However, its role in the initial phases of CD8(+) T effector cell
Padmanabhan P Pattabiraman et al.
The American journal of pathology, 185(2), 496-512 (2014-12-17)
Ocular hypertension arising from increased resistance to aqueous humor (AH) outflow through the trabecular meshwork is a primary risk factor for open-angle glaucoma, a leading cause of blindness. Ongoing efforts have found little about the molecular and cellular bases of
Glenn W Guglietta et al.
ACS nano, 9(2), 1820-1828 (2015-02-04)
Colloidal semiconductor nanocrystals have been used as building blocks for electronic and optoelectronic devices ranging from field-effect transistors to solar cells. Properties of the nanocrystal films depend sensitively on the choice of capping ligand to replace the insulating synthesis ligands.
Jun Rao et al.
Cancer letters, 358(1), 76-84 (2014-12-23)
Tumor cell stemness has been recognized as a key contributor to tumor initiation, progression and recurrence. Our previous studies have found that semaphorin-3F (SEMA3F), an axon guidance molecule in the development of central nervous system, inhibited the growth and metastasis
Xinde Chen et al.
Journal of medicinal chemistry, 58(21), 8529-8541 (2015-10-20)
Inhibition of lipoprotein-associated phospholipase A2 (Lp-PLA2) has been suggested to be a promising therapeutic strategy for several inflammation-associated diseases, including atherosclerosis, Alzheimer's disease, and diabetic macular edema. Herein, we report the discovery of a novel series of Lp-PLA2 inhibitors constructed
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