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Ke Chen et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(13), 3428-3441 (2016-11-24)
Purpose: Deregulation or mutation of theEZH2gene causes various tumors, including clear cell renal cell carcinoma (ccRCC). Although several splice variants of EZH2 have been identified, little is known about how EZH2 splicing is regulated or the contribution of alternative splicing...
Wanju Jiao et al.
Oncogene, 37(20), 2728-2745 (2018-03-08)
Recent studies reveal the emerging functions of enhancer RNAs (eRNAs) in gene expression. However, the roles of eRNAs in regulating the expression of heparanase (HPSE), an established endo-β-D-glucuronidase essential for cancer invasion and metastasis, still remain elusive. Herein, through comprehensive...
Felipe C Beckedorff et al.
PLoS genetics, 9(8), e1003705-e1003705 (2013-08-31)
The down-regulation of the tumor-suppressor gene RASSF1A has been shown to increase cell proliferation in several tumors. RASSF1A expression is regulated through epigenetic events involving the polycomb repressive complex 2 (PRC2); however, the molecular mechanisms modulating the recruitment of this...
Loss of long noncoding RNA FOXF1-AS1 regulates epithelial-mesenchymal transition, stemness and metastasis of non-small cell lung cancer cells.
Miao, L; Huang, Z; Zengli, Z; Li, H; Chen, Q; Yao, C; Cai, H; Xiao, Y; Xia, H; Wang, Y
Oncotarget null
Up-regulation of long noncoding RNA FALEC predicts poor prognosis and promotes melanoma cell proliferation through epigenetically silencing p21.
Ni, N; Song, H; Wang, X; Xu, X; Jiang, Y; Sun, J
Biomedicine and Pharmacotherapy null
Søren Lykke-Andersen et al.
Genes & development, 28(22), 2498-2517 (2014-11-19)
Eukaryotic RNAs with premature termination codons (PTCs) are eliminated by nonsense-mediated decay (NMD). While human nonsense RNA degradation can be initiated either by an endonucleolytic cleavage event near the PTC or through decapping, the individual contribution of these activities on...
Yan-Xing Guan et al.
Journal of cellular biochemistry, 119(10), 7971-7981 (2017-12-14)
To explore the mechanism of lnc SNHG20 in the regulation of proliferation, invasion, and migration of breast cancer cells. mRNA levels of SNHG20, miR-495, and HER2 were detected by qRT-PCR. Protein level of HER2 was measured by Western blot. Cell...
Long Non-coding RNA TUSC7, a Target of miR-23b, Plays Tumor-Suppressing Roles in Human Gliomas.
Shang, C; Guo, Y; Hong, Y; Xue, YX
Frontiers in Cellular Neuroscience null
Jianxin Wang et al.
International journal of oncology, 59(2) (2021-07-20)
Intrinsic or acquired resistance to temozolomide (TMZ) is a frequent occurrence in patients with glioblastoma (GBM). Accumulating evidence has indicated that the exosomal transfer of proteins and RNAs may confer TMZ resistance to recipient cells; however, the potential molecular mechanisms...
Kee K Kim et al.
Nucleic acids research, 39(8), 3064-3078 (2010-12-24)
Fox-1 family (Fox) proteins, which consist of Fox-1 (A2BP1), Fox-2 (Rbm9) and Fox-3 (NeuN) in mammals, bind to the RNA element UGCAUG and regulate alternative pre-mRNA splicing. However the mechanisms for Fox-regulated splicing are largely unknown. We analyzed the expression...
Carrie E Barnum et al.
Human molecular genetics, 29(12), 2076-2097 (2020-05-19)
Mutations of the RNA granule component TDRD7 (OMIM: 611258) cause pediatric cataract. We applied an integrated approach to uncover the molecular pathology of cataract in Tdrd7-/- mice. Early postnatal Tdrd7-/- animals precipitously develop cataract suggesting a global-level breakdown/misregulation of key...
Jianlan Gu et al.
Nucleic acids research, 45(10), 6177-6193 (2017-03-24)
In the brains of individuals with Alzheimer's disease (AD) and chronic traumatic encephalopathy, tau pathology is accompanied usually by intracellular aggregation of transactive response DNA-binding protein 43 (TDP-43). However, the role of TDP-43 in tau pathogenesis is not understood. Here...
Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS.
Shiga, A; Ishihara, T; Miyashita, A; Kuwabara, M; Kato, T; Watanabe, N; Yamahira et al.
Testing null
Knockdown of LncRNA ANRIL suppresses cell proliferation, metastasis, and invasion via regulating miR-122-5p expression in hepatocellular carcinoma.
Ma, J; Li, T; Han, X; Yuan, H
Journal of Cancer Research and Clinical Oncology null
Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3.
Han, D; Gao, X; Wang, M; Qiao, Y; Xu, Y; Yang, J; Dong, N; He, J; Sun, Q; Lv, G; Xu et al.
Oncotarget null
Diane Moujalled et al.
Human molecular genetics, 26(9), 1732-1746 (2017-03-24)
TAR DNA binding protein 43 (TDP-43) is a major disease-associated protein involved in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). Our previous studies found a direct association between TDP-43 and heterogeneous nuclear...
Jie Guo et al.
Oncology research, 25(7), 1189-1197 (2017-03-01)
Nasopharyngeal carcinoma (NPC) is a distinct head and neck cancer, which is occurring at a high frequency in Southern China. Emerging studies have shown that long noncoding RNAs (lncRNAs) play a critical role in carcinogenesis and progression. In this study...
Bo Li et al.
Molecular therapy. Nucleic acids, 19, 814-826 (2020-01-21)
Mesenchymal stem cells (MSCs) have been reported to hold promise to accelerate the wound-healing process in diabetic foot ulcer (DFU) due to the multilineage differentiation potential. Hence, this study intended to explore the wound healing role of MSC-derived exosomes containing...
Qingchun Lu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(7), 3957-3967 (2018-02-22)
Long noncoding RNAs participate in the progression and initiation of non-small cell lung cancer (NSCLC), although the mechanism remains unknown. The lncRNA identified as small nucleolar RNA host gene 1 ( SNHG1) is a novel lncRNA that is increased in...
TUG1 knockdown ameliorates atherosclerosis via up-regulating the expression of miR-133a target gene FGF1.
Zhang, L; Cheng, H; Yue, Y; Li, S; Zhang, D; He, R
Cardiovascular Pathology : the Official Journal of the Society For Cardiovascular Pathology null
LINC00037 Inhibits Proliferation of Renal Cell Carcinoma Cells in an Epidermal Growth Factor Receptor-Dependent Way.
Gong, X; Du, X; Xu, Y; Zheng, W
Cellular Physiology and Biochemistry null
Tong-Peng Xu et al.
Cell death & disease, 8(6), e2837-e2837 (2017-06-02)
Recent evidence indicates that E2F1 transcription factor have pivotal roles in the regulation of cellular processes, and is found to be dysregulated in a variety of cancers. Long non-coding RNAs (lncRNAs) are also reported to exert important effect on tumorigenesis....
Timothy E Baroni et al.
Methods in molecular biology (Clifton, N.J.), 383, 227-244 (2008-01-26)
In this chapter, we present an approach using genomic and ribonomic profiling to investigate functional gene programs in a tumor growth model. To reach this goal, ribonomic profiling was combined with RNA interference in a tumor dormancy model. Strategies merging...
Caifeng Yan et al.
Scientific reports, 6, 22640-22640 (2016-03-05)
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is implicated in liver cell proliferation. However, its role in hepatic steatosis and insulin resistance remain poorly understood. The aim of this study was to investigate the effects of MALAT1 on hepatic lipid accumulation...
Xianxiang Cao et al.
Cancer gene therapy, 25(1-2), 10-17 (2017-12-14)
More and more evidences have ensured the crucial functions of long non-coding RNAs (lncRNAs) in multiple tumors. It has been discovered that lncRNA-SNHG16 is involved in many tumors. Even so, it is still necessary to study SNHG16 comprehensively in bladder...
Knockdown of pseudogene derived from lncRNA DUXAP10 inhibits cell proliferation, migration, invasion, and promotes apoptosis in pancreatic cancer.
Lian, Y; Xiao, C; Yan, C; Chen, D; Huang, Q; Fan, Y; Li, Z; Xu, H
Journal of Cellular Biochemistry null
Long intergenic non-coding RNA 00152 promotes tumor cell cycle progression by binding to EZH2 and repressing p15 and p21 in gastric cancer.
Chen, WM; Huang, MD; Sun, DP; Kong, R; Xu, TP; Xia, R; Zhang, EB; Shu, YQ
Oncotarget null
miR?188 suppresses tumor progression by targeting SOX4 in pediatric osteosarcoma.
Pan, L; Meng, L; Liang, F; Cao, L
Molecular Medicine Reports null
Young-Dae Kim et al.
Nucleic acids research, 39(10), 4300-4314 (2011-02-08)
Nuclear speckles are known to be the storage sites of mRNA splicing regulators. We report here the identification and characterization of a novel speckle protein, referred to as NSrp70, based on its subcellular localization and apparent molecular weight. This protein...
Ming Li et al.
Cell death & disease, 9(5), 554-554 (2018-05-12)
Mesenchymal stem cells (MSCs) are important pluripotent stem cells and a major source of adipocytes in the body. However, the mechanism of adipogenic differentiation has not yet been completely elucidated. In this study, the long noncoding RNA GAS5 was found...
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