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David J Burke et al.
International journal of molecular sciences, 16(10), 23630-23650 (2015-10-09)
In this study, we investigated the effect of positively and negatively charged Fe₃O₄ and TiO₂ nanoparticles (NPs) on the growth of soybean plants (Glycine max.) and their root associated soil microbes. Soybean plants were grown in a greenhouse for six
Juan D Chavez et al.
Nature protocols, 14(8), 2318-2343 (2019-07-05)
This protocol describes a workflow for utilizing large-scale cross-linking with mass spectrometry (XL-MS) to make systems-level structural biology measurements in complex biological samples, including cells, isolated organelles, and tissue samples. XL-MS is a structural biology technique that provides information on
Meagan J Bemer et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 20(10), 1544-1552 (2014-06-14)
Mycophenolic acid, the active metabolite of mycophenolate mofetil (MMF), inhibits inosine monophosphate dehydrogenase (IMPDH) activity. IMPDH is the rate-limiting enzyme involved in de novo synthesis of guanosine nucleotides and catalyzes the oxidation of inosine 5'-monophosphate to xanthosine 5'-monophosphate (XMP). We
Ju-Young Kim et al.
Drug development and industrial pharmacy, 41(2), 292-299 (2013-11-21)
The purpose of the present study was to prepare desmopressin orally disintegrating microparticles (ODMs) using organic-aqueous crossover coating process which featured an organic sub-coating followed by an aqueous active coating. Sucrose beads and hydroxypropyl cellulose (HPC) were used as inert
Mykhailo Azarkh et al.
Nature protocols, 8(1), 131-147 (2012-12-22)
Double electron-electron resonance (DEER) is an electron paramagnetic resonance (EPR) technique used to determine distance distributions in the nanometer range between spin labels by measuring their dipole-dipole interactions. Here we describe how in-cell DEER can be applied to spin-labeled DNA
Blanca Estela Jaramillo-Loranca et al.
Synapse (New York, N.Y.), 69(4), 213-225 (2015-02-17)
Sigma (σ) receptors have generated a great deal of interest due to their possible role in psychosis, neuroprotection, and various other behaviors including addictive processes. Sigma receptors have been located in brain areas involved in motor functions, including the dopaminergic
Madhuri Chakravarthy et al.
Genes, 10(9) (2019-09-25)
Amyloid beta-peptide is produced by the cleavage of amyloid precursor protein by two secretases, a β-secretase, beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) and a γ-secretase. It has been hypothesised that partial inhibition of BACE1 in individuals with a
A Kaufmann et al.
Analytica chimica acta, 862, 41-52 (2015-02-16)
An ultra-high performance liquid chromatography based method, coupled to high resolution mass spectrometry (UHPLC-HRMS), was developed to permit the detection and quantification of various nitrofuran and chloramphenicol residues in a number of animal based food products. This method is based
A Farag et al.
Journal of dental research, 93(12), 1313-1319 (2014-10-02)
The periodontal ligament is the key tissue facilitating periodontal regeneration. This study aimed to fabricate decellularized human periodontal ligament cell sheets for subsequent periodontal tissue engineering applications. The decellularization protocol involved the transfer of intact human periodontal ligament cell sheets
Mahdi Shahmiri et al.
Scientific reports, 5, 16378-16378 (2015-11-18)
Aurein 1.2 is a 13 residue antimicrobial peptide secreted by the Australian tree frog Litoria Aurea. It is a surface-acting membrane disrupting peptide that permeabilizes bacterial membranes via the carpet mechanism; the molecular details of this process are mostly unknown.
Lisa Fischer et al.
International journal of legal medicine, 129(2), 279-287 (2014-10-12)
Insurance agencies might request laboratories to differentiate whether a deceased has been a smoker or not to decide about refunding of his nonsmoker rate. In this context, the question on a solid proof of tobacco alkaloids and major metabolites in
Michael A Gardner et al.
Journal of analytical toxicology, 39(2), 118-125 (2014-12-11)
Fentanyl is a synthetic narcotic anesthetic ∼80-100 times more potent than morphine. Owing to the potential for its abuse, the drug may be included in a forensic toxicology work-up, which requires fast, precise and accurate measurements. Here, the stability of
Yunjia Yang et al.
Journal of agricultural and food chemistry, 62(46), 11130-11137 (2014-10-29)
This study aimed to develop a selective analytical method for the simultaneous determination of seven bisphenol analogues in beverage and canned food samples by using a new molecularly imprinted polymer (MIP) as a sorbent for solid-phase extraction (SPE). Liquid chromatography
Yi Hong et al.
Colloids and surfaces. B, Biointerfaces, 123, 68-74 (2014-09-13)
In this study, we investigated the differences between amorphous and anatase TiO2 at the biomolecular level which could explain differences in the osteoblast response on these surfaces. The number of surface hydroxyl groups in the TiOHT form on amorphous and
Mohammad Saraji et al.
Journal of chromatography. A, 1366, 24-30 (2014-09-28)
A magnesium-aluminum layered double hydroxide coated on magnetic nanoparticles was synthesized and used as a sorbent to extract some phenolic acids including p-hydroxy benzoic acid, caffeic acid, syringic acid, p-coumaric acid and ferulic acid from fruit juices. After extraction, the
Ravi Chand Bollineni et al.
The Analyst, 140(24), 8109-8117 (2015-11-07)
Depletion of highly abundant proteins is an approved step in blood plasma analysis by mass spectrometry (MS). In this study, we explored a precipitation and differential protein solubility approach as a fractionation strategy for abundant protein removal from plasma. Total
Stef R A Molenaar et al.
Journal of chromatography. A, 1639, 461922-461922 (2021-02-05)
A peak-tracking algorithm was developed for use in comprehensive two-dimensional liquid chromatography coupled to mass spectrometry. Chromatographic peaks were tracked across two different chromatograms, utilizing the available spectral information, the statistical moments of the peaks and the relative retention times
Yufeng Hu et al.
Nature communications, 6, 6634-6634 (2015-03-24)
Flexibility is an intrinsic property of proteins and essential for their biological functions. However, because of structural flexibility, obtaining high-quality crystals of proteins with heterogeneous conformations remain challenging. Here, we show a novel approach to immobilize traditional precipitants onto molecularly
Maira Di Tano et al.
Nature communications, 11(1), 2332-2332 (2020-05-13)
Fasting-mimicking diets delay tumor progression and sensitize a wide range of tumors to chemotherapy, but their therapeutic potential in combination with non-cytotoxic compounds is poorly understood. Here we show that vitamin C anticancer activity is limited by the up-regulation of
Johongir M Muradov et al.
Experimental neurology, 249, 59-73 (2013-08-28)
The mechanisms contributing to axon loss after spinal cord injury (SCI) are largely unknown but may involve microvascular loss as we have previously suggested. Here, we used a mild contusive injury (120 kdyn IH impactor) at T9 in rats focusing
Mei-Quan Cai et al.
Environmental science and pollution research international, 22(3), 1854-1867 (2014-09-10)
A simultaneous determination method of 14 multi-class pharmaceuticals using solid-phase extraction (SPE) followed by high-performance liquid chromatography-tandem mass spectrometer (HPLC-MS/MS) was established to measure the occurrence and distribution of these pharmaceuticals in tap water and a drinking water treatment plant
Alexandre Grand-Guillaume Perrenoud et al.
Journal of chromatography. A, 1262, 205-213 (2012-09-25)
While neutral and acidic compounds are well separated by supercritical fluid chromatography (SFC), basic analytes are more challenging to separate and often problems occur with their peak shapes. Two different methods were explored in the present paper to reduce these
Ahmad Umar et al.
Dalton transactions (Cambridge, England : 2003), 44(48), 21081-21087 (2015-11-26)
Herein, we report the development of a simple and highly sensitive hydroquinone (HQ) chemical sensor based on an electrochemically activated iron-doped (Fe-doped) zinc oxide nanorod (ZnO NR) modified screen-printed electrode (SPE). The Fe-doped ZnO NRs were prepared using a hydrothermal
Saroj Kumar Das et al.
BMC neuroscience, 16, 2-2 (2015-04-17)
Although there have been several reports on social isolation induced mood alterations, the independent contribution of monotonous environment in mediating mood alterations has been less studied. In view of the above, the present study is aimed at investigating the relative
Marzieh Enteshari Najafabadi et al.
Journal of pharmaceutical and biomedical analysis, 107, 244-250 (2015-01-28)
Magnetic nanoparticles (MNPs) conjugated with aptamer was developed for the selective extraction of adenosine in urine samples followed by electrospray ionization-ion mobility spectrometry (ESI-IMS). The ion mobility spectrum of adenosine showed two peaks at low concentrations and two more peaks
Konstantin Chingin et al.
Analytical chemistry, 84(15), 6856-6862 (2012-07-12)
We introduce an online multiple-junction capillary isoelectric focusing fractionator (OMJ-CIEF) for separation of biological molecules in solution by pI. In OMJ-CIEF, the separation capillary is divided into seven equal sections joined with each other via tubular Nafion membrane insertions. Each
Hanzhi Wu et al.
Talanta, 131, 640-644 (2014-10-05)
Biologically active peptides play a role in plant signaling and defense. Elderberry juice is known to contain a variety of anthocyanin compounds, a sub-set of polyphenols, which are responsible for the deep purple color of the juice. In this paper
Bojan Mitrovic et al.
Langmuir : the ACS journal of surfaces and colloids, 29(2), 696-700 (2012-12-19)
A cationic polymer nanobrush was synthesized, attached to a MALDI target, and used for the fractionation of peptides and proteins based on their pI, prior to analysis by MALDI-MS. The cationic polymer nanobrush was synthesized on a gold substrate by
Hong Li et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 20(8), 1121-1129 (2014-04-15)
A novel approach to personalizing postgrafting immunosuppression in hematopoietic cell transplantation (HCT) recipients is evaluating inosine monophosphate dehydrogenase (IMPDH) activity as a drug-specific biomarker of mycophenolic acid (MPA)-induced immunosuppression. This prospective study evaluated total MPA, unbound MPA, and total MPA
Stefan Harmsen et al.
Science translational medicine, 7(271), 271ra7-271ra7 (2015-01-23)
The inability to visualize the true extent of cancers represents a significant challenge in many areas of oncology. The margins of most cancer types are not well demarcated because the cancer diffusely infiltrates the surrounding tissues. Furthermore, cancers may be
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