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221228

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Dae-Hee Lee et al.
PloS one, 10(3), e0117224-e0117224 (2015-03-03)
The characteristics of anterior cruciate ligament (ACL)-derived mesenchymal stem cells (MSCs), such as proportion and multilineage potential, can be affected by donor age. However, the qualitative and quantitative features of ACL MSCs isolated from younger and older individuals have not...
Krisztina Hitri et al.
Vaccine, 37(29), 3866-3875 (2019-06-05)
In this work, we explore the effects of O-acetylation on the physical and immunological characteristics of the WHO International Standards of Vi polysaccharide (Vi) from both Citrobacter freundii and Salmonella enterica serovar Typhi. We find that, although structurally identical according...
Yaxi Hu et al.
Food chemistry, 176, 123-129 (2015-01-28)
A novel biosensor combining molecularly imprinted polymers and surface-enhanced Raman spectroscopy (MIPs-SERS) determines melamine in whole milk. MIPs were synthesized by bulk polymerization of melamine (template), methacrylic acid (functional monomer), ethylene glycol dimethacrylate (cross-linking agent) and 2,2'-azobisisobutyronitrile (initiator). Static and...
Ana R Ribeiro et al.
Journal of chromatography. A, 1418, 140-149 (2015-10-04)
The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of 37 micropollutants including Priority Substances (Directive 2013/39/EU), substances of...
Vinod Vellora Thekkae Padil et al.
Carbohydrate polymers, 121, 468-476 (2015-02-11)
Electrospun nanofibre membranes from blend solutions of deacetylated gum kondagogu and polyvinyl alcohol of various weight proportions were prepared. The electrospun membrane was cross linked by heating at 150°C for 6h and later modified by methane plasma treatment. Membranes were...
Gozde Unsoy et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(5), 641-648 (2014-06-02)
The use of nanotechnology in cancer treatment offers exciting opportunities, including the possibility of destroying tumors with minimal damage to healthy tissue by novel targeted drug delivery systems. pH differences between healthy and tumor microenvironment provide pH responsive release of...
Amy E Clipperton-Allen et al.
Journal of the American Association for Laboratory Animal Science : JAALAS, 54(6), 718-730 (2015-12-04)
Few studies have evaluated the long-term effects of providing environmental resources to mice. This consideration is important given that mice are often maintained in vivaria for months. We evaluated the effects of providing simple cage resources (wood wool, cotton nesting...
Florencia Harari et al.
Thyroid : official journal of the American Thyroid Association, 25(11), 1199-1208 (2015-09-04)
Impaired thyroid function is a common side effect of lithium medication. Recent data indicate that lithium exposure through drinking water, although providing much lower doses than the medication, may also affect thyroid hormone levels. However, the effects in susceptible groups...
Dong Wei et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 971, 133-140 (2014-10-08)
Dexpramipexole (DEX) was being investigated in clinical studies for the treatment of amyotrophic lateral sclerosis (ALS). To monitor the potential chiral interconversion of dexpramipexole to pramipexole (PPX) in vivo, a highly sensitive and selective chiral LC-MS/MS assay was developed and...
Ming-Chuan Wang et al.
Analytical and bioanalytical chemistry, 407(5), 1343-1356 (2014-12-10)
Tyrosine phosphorylation is an important regulator of signaling in cellular pathways, and dysregulated tyrosine phosphorylation causes several diseases. Mass spectrometry has revealed the importance of global phosphoproteomic characterization. Analysis of tyrosine phosphorylation by studying the mass-spectrometry (MS)-determined phosphoproteome remains difficult...
J C Naviaux et al.
Translational psychiatry, 4, e400-e400 (2014-06-18)
Autism spectrum disorders (ASDs) now affect 1-2% of the children born in the United States. Hundreds of genetic, metabolic and environmental factors are known to increase the risk of ASD. Similar factors are known to influence the risk of schizophrenia...
Joost Westerhout et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 57, 11-24 (2014-01-28)
Children and adults with malignant diseases have a high risk of prevalence of the tumor in the central nervous system (CNS). As prophylaxis treatment methotrexate is often given. In order to monitor methotrexate exposure in the CNS, cerebrospinal fluid (CSF)...
Elena Sánchez-López et al.
Journal of chromatography. A, 1363, 356-362 (2014-08-03)
Two chiral methodologies were developed by capillary electrophoresis (CE) with UV and mass spectrometry (MS) detection to ensure the quality control of the drug duloxetine, commercialized as a pure enantiomer. Both methods were optimized to achieve a high baseline enantioresolution...
Kurt G Pike et al.
Journal of medicinal chemistry, 58(5), 2326-2349 (2015-02-03)
High throughput screening followed by a lead generation campaign uncovered a novel series of urea containing morpholinopyrimidine compounds which act as potent and selective dual inhibitors of mTORC1 and mTORC2. We describe the continued compound optimization campaign for this series...
Ana Rita Ribeiro et al.
Journal of chromatography. A, 1363, 226-235 (2014-07-23)
The interest for environmental fate assessment of chiral pharmaceuticals is increasing and enantioselective analytical methods are mandatory. This study presents an enantioselective analytical method for the quantification of seven pairs of enantiomers of pharmaceuticals and a pair of a metabolite....
Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome.
Pinto, et al.
Neuron, 108, 887-904 (2021)
Emily K Cushnie et al.
PloS one, 9(7), e101627-e101627 (2014-07-16)
With greater than 500,000 orthopaedic procedures performed in the United States each year requiring a bone graft, the development of novel graft materials is necessary. We report that some porous polymer/ceramic composite scaffolds possess intrinsic osteoinductivity as shown through their...
Bojan Mitrovic et al.
Langmuir : the ACS journal of surfaces and colloids, 29(2), 696-700 (2012-12-19)
A cationic polymer nanobrush was synthesized, attached to a MALDI target, and used for the fractionation of peptides and proteins based on their pI, prior to analysis by MALDI-MS. The cationic polymer nanobrush was synthesized on a gold substrate by...
Joanna H Clark et al.
Journal of the American Chemical Society, 133(4), 1016-1032 (2010-12-17)
Charge transfer between metal ions occupying distinct crystallographic sublattices in an ordered material is a strategy to confer visible light absorption on complex oxides to generate potentially catalytically active electron and hole charge carriers. CaCu3Ti4O12 has distinct octahedral Ti4+ and...
Stefan Harmsen et al.
Science translational medicine, 7(271), 271ra7-271ra7 (2015-01-23)
The inability to visualize the true extent of cancers represents a significant challenge in many areas of oncology. The margins of most cancer types are not well demarcated because the cancer diffusely infiltrates the surrounding tissues. Furthermore, cancers may be...
Marzieh Enteshari Najafabadi et al.
Journal of pharmaceutical and biomedical analysis, 107, 244-250 (2015-01-28)
Magnetic nanoparticles (MNPs) conjugated with aptamer was developed for the selective extraction of adenosine in urine samples followed by electrospray ionization-ion mobility spectrometry (ESI-IMS). The ion mobility spectrum of adenosine showed two peaks at low concentrations and two more peaks...
Isolation and characterization of mesenchymal stem cells.
Odabas SA, et al.
Bone Marrow and Stem Cell Transplantation., 47-63 (2014)
Saroj Kumar Das et al.
BMC neuroscience, 16, 2-2 (2015-04-17)
Although there have been several reports on social isolation induced mood alterations, the independent contribution of monotonous environment in mediating mood alterations has been less studied. In view of the above, the present study is aimed at investigating the relative...
Sena Caglar et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 988, 25-32 (2015-03-10)
On-line solid-phase extraction (SPE) is becoming an increasingly widespread technique in the clean-up of complex matrices such as body fluids, prior to chromatographic analysis. The use of small SPE columns instead of disposable SPE cartridges allows multiple injections and complete...
Michael J Boundy et al.
Journal of chromatography. A, 1387, 1-12 (2015-02-24)
Routine regulatory monitoring of paralytic shellfish toxins (PST) commonly employs oxidative derivitisation and complex liquid chromatography fluorescence detection methods (LC-FL). The pre-column oxidation LC-FL method is currently implemented in New Zealand and the United Kingdom. When using this method positive...
Camilla Benevides Freitas et al.
Talanta, 147, 335-341 (2015-11-26)
This report describes the development of an analytical methodology on microchip electrophoresis (ME) devices coupled with capacitively coupled contactless conductivity detection (C(4)D) to monitor inorganic anions in environmental samples. The buffer composition as well as detection operating parameters were optimized...
Konstantin Chingin et al.
Analytical chemistry, 84(15), 6856-6862 (2012-07-12)
We introduce an online multiple-junction capillary isoelectric focusing fractionator (OMJ-CIEF) for separation of biological molecules in solution by pI. In OMJ-CIEF, the separation capillary is divided into seven equal sections joined with each other via tubular Nafion membrane insertions. Each...
Hanzhi Wu et al.
Talanta, 131, 640-644 (2014-10-05)
Biologically active peptides play a role in plant signaling and defense. Elderberry juice is known to contain a variety of anthocyanin compounds, a sub-set of polyphenols, which are responsible for the deep purple color of the juice. In this paper...
Hong Li et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 20(8), 1121-1129 (2014-04-15)
A novel approach to personalizing postgrafting immunosuppression in hematopoietic cell transplantation (HCT) recipients is evaluating inosine monophosphate dehydrogenase (IMPDH) activity as a drug-specific biomarker of mycophenolic acid (MPA)-induced immunosuppression. This prospective study evaluated total MPA, unbound MPA, and total MPA...
Huanchen Wang et al.
Biochemistry, 54(42), 6462-6474 (2015-10-01)
Iron-sulfur (Fe-S) clusters are widely distributed protein cofactors that are vital to cellular biochemistry and the maintenance of bioenergetic homeostasis, but to our knowledge, they have never been identified in any phosphatase. Here, we describe an iron-sulfur cluster in Asp1...
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