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Matthew K Gelber et al.
Lab on a chip, 15(7), 1736-1741 (2015-02-12)
Here we demonstrate a method for creating multilayer or 3D microfluidics by casting a curable resin around a water-soluble, freestanding sacrificial mold. We use a purpose-built 3D printer to pattern self-supporting filaments of the sugar alcohol isomalt, which we then
Masoud Samet et al.
Organic & biomolecular chemistry, 13(7), 2170-2176 (2014-12-24)
Different strategies are employed in designing strong and selective anion receptors but stereoelectronic effects have been largely ignored. In this work, the stereo configuration of a non-interacting ether is found to have a large impact of more than two orders
Di Wen et al.
PLoS genetics, 11(3), e1005038-e1005038 (2015-03-17)
Corpus allatum (CA) ablation results in juvenile hormone (JH) deficiency and pupal lethality in Drosophila. The fly CA produces and releases three sesquiterpenoid hormones: JH III bisepoxide (JHB3), JH III, and methyl farnesoate (MF). In the whole body extracts, MF
Daniel Lee et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(45), 16047-16058 (2015-09-24)
Silicon nanoparticles (NPs) serve a wide range of optical, electronic, and biological applications. Chemical grafting of various molecules to Si NPs can help to passivate their reactive surfaces, "fine-tune" their properties, or even give them further interesting features. In this
Kelly M Mabry et al.
Biomaterials, 74, 31-41 (2015-10-05)
Valvular interstitial cells (VICs) actively maintain and repair heart valve tissue; however, persistent activation of VICs to a myofibroblast phenotype can lead to aortic stenosis. To better understand and quantify how microenvironmental cues influence VIC phenotype and myofibroblast activation, we
Jérôme Cotton et al.
Journal of agricultural and food chemistry, 62(46), 11335-11345 (2014-10-31)
Analytical methods for food control are mainly focused on restricted lists of well-known contaminants. This paper shows that liquid chromatography-high-resolution mass spectrometry (LC/ESI-HRMS) associated with the data mining tools developed for metabolomics can address this issue by enabling (i) targeted
Sonika Batra et al.
Biomedical chromatography : BMC, 28(6), 815-825 (2014-05-28)
Enantiomeric separation of racemic mexiletine and fluoxetine was achieved using three chiral derivatizing reagents (CDRs) based on (S)-naproxen. Diastereomers were synthesized by reaction of mexiletine or fluoxetine with the CDRs and were separated on a C18 column under reversed-phase conditions
Qingyu Dou et al.
International journal of molecular sciences, 16(9), 22299-22318 (2015-09-22)
Nicotinamide phosphoribosyltransferase (NAMPT) has crucial roles for myocardial development, cardiomyocyte energy metabolism and cell death/survival by regulating NAD⁺-dependent sirtuin-1 (SIRT1) deacetylase. This study aimed to determine if the single nucleotide polymorphisms (SNPs) of the NAMPT gene may affect the susceptibility
Daniel J Rubin et al.
ACS nano, 9(3), 3360-3368 (2015-03-12)
The rigid geometry and tunable chemistry of D,L-cyclic peptides makes them an intriguing building-block for the rational design of nano- and microscale hierarchically structured materials. Herein, we utilize a combination of electron microscopy, nanomechanical characterization including depth sensing-based bending experiments
D Pasupuleti et al.
Journal of chromatography. A, 1421, 162-170 (2015-10-03)
Alkyl esters of fatty acids (FAAEs) with carbon numbers from 8 to 20 formed protonated monomers and proton bound dimers through atmospheric pressure chemical ionization reactions and these gas ions were characterized for their field dependent mobility coefficients using differential
Shannon L Haughney et al.
Nanoscale, 6(22), 13770-13778 (2014-10-07)
Acute respiratory infections represent a significant portion of global morbidity and mortality annually. There is a critical need for efficacious vaccines against respiratory pathogens. To vaccinate against respiratory disease, pulmonary delivery is an attractive route because it mimics the route
S Rudnick-Glick et al.
Journal of nanobiotechnology, 13, 80-80 (2015-11-19)
Bisphosphonate (BP) compounds are widely used in the treatment of bone disorders. This group of drugs with a high affinity to Ca(+2) ions is rapidly attracted to bone mineral, especially in areas of high resorption. We have engineered unique biodegradable
Marco Parolini et al.
Journal of hazardous materials, 285, 1-10 (2014-12-03)
Synthetic musk compounds (SMCs) are extensively used as fragrances in several personal care products and have been recognized as emerging aquatic pollutants. Among SMCs, galaxolide (HHCB) and tonalide (AHTN) are extensively used and have been measured in aquatic ecosystems worldwide.
Wojciech Prus et al.
The Science of the total environment, 518-519, 266-279 (2015-03-17)
The organic contamination of Antarctic soils and terrestrial sediments from nearby of five polar scientific stations on King George Island (Antarctica) was investigated. Gas chromatography-mass spectrometry (GC-MS) was applied to find composition of dichloromethane extracts of soil and terrestrial sediments.
Yunxia Jiang et al.
International journal of pharmaceutics, 475(1-2), 475-484 (2014-09-16)
The purpose of this study was to develop a sustained-release drug delivery system based on the injectable PLGA microspheres loaded with andrographolide. The andrographolide loaded PLGA microspheres were prepared by emulsion solvent evaporation method with optimization of formulation using response
Naghmeh Soltani et al.
The Science of the total environment, 505, 712-723 (2014-12-03)
This study investigates trace elements and PAHs content in road dust of Isfahan metropolis, central Iran. The mean concentrations of As, Cd, Cu, Ni, Pb, Sb and Zn are 22.15, 2.14, 182.26, 66.63, 393.33, 6.95 and 707.19 mg kg(-1), respectively.
Daishun Ling et al.
ACS nano, 8(8), 8027-8039 (2014-08-06)
Hepatocellular carcinoma (HCC) has one of the worst prognoses for survival as it is poorly responsive to both conventional chemotherapy and mechanism-directed therapy. This results from a lack of therapeutic concentration in the tumor tissue coupled with the highly toxic
Yu Zhang et al.
Environmental science and pollution research international, 21(16), 9468-9476 (2013-08-15)
Nonylphenol ethoxylates (NPEOs) with low ethoxylation degree (NPav₂EO; containing two ethoxy units on average) and estrogenic properties are the intermediate products of nonionic surfactant NPEOs. To better understand the environmental fate of low-ethoxylated NPEOs, phylogenetically diverse low-ethoxylated NPEO-degrading bacteria were
Abd Almonem Doolaanea et al.
Journal of microencapsulation, 31(6), 600-608 (2014-04-05)
The aim of this study is to investigate the cell uptake of Nigella sativa oil (NSO)-PLGA microparticle by neuron-like PC-12 cells in comparison to surfactants; hydrophilic (Tween 80 & Triton X100) and hydrophobic (Span 80). Solvent evaporation was used to
Tao Jiang et al.
International journal of pharmaceutics, 475(1-2), 547-557 (2014-09-10)
Delivering drugs specifically to bone tissue is very challenging due to the architecture and structure of bone tissue. Poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles (NPs) hold great promise for the delivery of therapeutics to bone tissue. The goal of the present research
Akiyoshi Hirata et al.
Journal of the American Chemical Society, 136(32), 11546-11554 (2014-07-19)
A polyamide containing N-methylpyrrole (Py) and N-methylimidazole (Im), designated PIPA, binds with high affinity and specificity to specific nucleotide sequences in the minor groove of double-helical DNA. Based on a recent report of the synthesis of PIPA for telomere visualization
Seyedsina Moeinzadeh et al.
Tissue engineering. Part A, 21(1-2), 134-146 (2014-07-23)
An attractive approach to reduce the undesired side effects of bone morphogenetic proteins (BMPs) in regenerative medicine is to use osteoinductive peptide sequences derived from BMPs. Although the structure and function of BMPs have been studied extensively, there is limited
Rosa Ana Pérez et al.
Analytical and bioanalytical chemistry, 407(7), 1913-1924 (2015-02-04)
Two magnetic solid-phase extraction methods (mSPE) were developed and compared for the extraction and preconcentration of polychlorinated biphenyls (PCBs) from water and soil leachates. Analyses were carried out by gas chromatography coupled to triple quadrupole mass spectrometry. The mSPE extraction
Nathalie Bock et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(2), 366-377 (2014-03-25)
The fabrication of tailored microparticles for delivery of therapeutics is a challenge relying upon a complex interplay between processing parameters and materials properties. The emerging use of electrospraying allows better tailoring of particle morphologies and sizes than current techniques, critical
Kai Yu et al.
Environmental technology, 36(5-8), 1008-1015 (2014-10-18)
The polycyclic aromatic hydrocarbons (PAHs) in crumb tyre rubber were firstly degraded under UV irradiation in the presence of rutile TiO2 and hydrogen peroxide. The effects of light intensity, catalyst amount, oxidant amount, initial pH value, co-solvent content, and reaction
Markus W Tackenberg et al.
International journal of pharmaceutics, 478(2), 597-605 (2014-12-17)
Essential oils and other liquid active pharmaceutical ingredients (APIs) are frequently microencapsulated to improve shelf life, handling, and for tailoring release. A glassy solid solution (GSS), a single-phase system, where the excipient is plasticized by the API, could be an
Shohei Takai et al.
Journal of applied toxicology : JAT, 36(1), 35-47 (2015-04-23)
Drug-induced liver injury (DILI) is the most frequent cause of post-marketing warnings and withdrawals. Amiodarone (AMD), an antiarrhythmic, presents a risk of liver injury in humans, and its metabolites, formed by cytochrome P450 3A4, are likely more toxic to hepatocytes
Maria João Rocha et al.
Archives of environmental contamination and toxicology, 67(3), 389-401 (2014-07-13)
The Lima River is a Spanish–Portuguese water body. Notwithstanding the fact that the river incorporates protected natural areas, levels of endocrine-disrupting compounds (EDCs) within its waters have never been measured; such EDCs include the following: natural and pharmaceutical oestrogens (17β-estradiol
Christ De Rooij et al.
Environmental monitoring and assessment, 97(1-3), 3-22 (2004-09-21)
This risk assessment on dichloromethane was carried out specifically for the marine environment, following methodology given in the EU risk assessment Regulation (1488/94) and Guidance Document of the EU New and Existing Substances Regulation (TGD, 1997). The study consists of
Romina Vitale et al.
ChemMedChem, 9(2), 323-336 (2014-01-10)
N-Acylethanolamine acid amidase (NAAA) is a cysteine amidase that preferentially hydrolyzes saturated or monounsaturated fatty acid ethanolamides (FAEs), such as palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), which are endogenous agonists of nuclear peroxisome proliferator-activated receptor-α (PPAR-α). Compounds that feature an α-amino-β-lactone
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