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Le T Lu et al.
Nanoscale, 7(46), 19596-19610 (2015-11-07)
In our present work, magnetic cobalt ferrite (CoFe2O4) nanoparticles have been successfully synthesised by thermal decomposition of Fe(III) and Co(II) acetylacetonate compounds in organic solvents in the presence of oleic acid (OA)/ oleylamine (OLA) as surfactants and 1,2-hexadecanediol (HDD) or
Emanuela Pannia et al.
Behavioural brain research, 278, 1-11 (2014-09-30)
High multivitamin (10-fold, HV) and high folic acid (Fol) diets fed to pregnant Wistar rats increase body weight and characteristics of the metabolic syndrome in their offspring. Our objective was to determine the effects of a HV maternal diet on
Maria Danielma Dos Santos Reis et al.
Immunity & ageing : I & A, 12, 18-18 (2015-10-31)
Thymic involution is thought to be an important factor of age related immunodeficiency. Understanding the molecular mechanisms of human thymic senescence may lead to the discovery of novel therapeutic approaches aimed at the reestablishment of central and peripheral T cell
Christina A Von Roemeling et al.
Oncotarget, 5(14), 5320-5334 (2014-07-01)
Currently there is a lack of targeted therapies that lead to long-term attenuation or regression of disease in patients with advanced clear cell renal cell carcinoma (ccRCC). Our group has implemented a high-throughput genetic analysis coupled with a high-throughput proliferative
Philip Jermann et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(33), E3415-E3421 (2014-08-06)
Trimethylation of histone H3 at lysine 27 (H3K27me3) is a chromatin mark associated with Polycomb-mediated gene repression. Despite its critical role in development, it remains largely unclear how this mark is targeted to defined loci in mammalian cells. Here, we
Emma Brooks et al.
The Science of the total environment, 537, 203-212 (2015-08-19)
Rising dissolved organic carbon (DOC) concentrations in many upland UK catchments represents a challenge for drinking water companies, in particular due to the role of DOC as a precursor in the formation of trihalomethanes (THMs). Whereas traditionally, the response of
Ying Han et al.
International journal of clinical and experimental pathology, 8(6), 7131-7139 (2015-08-12)
This study aimed to characterize the miR-21 and evaluated its clinical significance. Total RNA was extracted from 30 pairs of fresh specimens of cervical cancer and normal tissues. The expression levels of the miR-21-3p and miR-21-5p were detected by quantitative
Rahul Bhattacharjee et al.
Biology of reproduction, 92(3), 65-65 (2015-01-09)
The signaling enzyme glycogen synthase kinase 3 (GSK3) exists as two isoforms-GSK3A and GSK3B. Protein phosphorylation by GSK3 has important signaling roles in several cells. In our past work, we found that both isoforms of GSK3 are present in mouse
Patrick Danaher et al.
Forensic science international. Genetics, 14, 18-30 (2014-10-04)
A DNA profile from the perpetrator does not reveal, per se, the circumstances by which it was transferred. Body fluid identification by mRNA profiling may allow extraction of contextual 'activity level' information from forensic samples. Here we describe the development
Ziyao Zhou et al.
PloS one, 10(2), e0116935-e0116935 (2015-02-07)
In the giant panda, adaptation to a high-fiber environment is a first step for the adequate functioning of intestinal bacteria, as the high cellulose content of the gut due to the panda's vegetarian appetite results in a harsh environment. As
Tsutomu Ishi-i et al.
Organic & biomolecular chemistry, 13(6), 1818-1828 (2014-12-17)
In this study, we report a preparation and an aggregate emission behavior of an amphiphilic donor-acceptor dye, which is composed of a triphenylamine-benzothiadiazole donor-acceptor chromophore and two water-soluble hexa(ethylene glycol) chains. The dye is strongly fluorescent in nonpolar solutions such
Birgit Andrée et al.
Basic research in cardiology, 109(6), 441-441 (2014-09-19)
Generating cellularized 3D constructs with clinical relevant dimensions is challenged by nutrition supply. This is of utmost importance for cardiac tissue engineering, since cardiomyocytes are extremely sensitive to malnutrition and hypoxia in vitro and after implantation. To develop a perfusable
High activity and regenerability of a palladium-gold catalyst for chloroform degradation.
Velazquez JC, et al.
Journal of Chemical Technology and Biotechnology (2015)
Yuya Tanaka et al.
Journal of bacteriology, 196(18), 3249-3258 (2014-07-02)
The transcriptional regulator GntR1 downregulates the genes for gluconate catabolism and pentose phosphate pathway in Corynebacterium glutamicum. Gluconate lowers the DNA binding affinity of GntR1, which is probably the mechanism of gluconate-dependent induction of these genes. In addition, GntR1 positively
Charles D Rutter et al.
Applied microbiology and biotechnology, 99(17), 7359-7368 (2015-07-02)
Lipids are naturally derived products that offer an attractive, renewable alternative to petroleum-based hydrocarbons. While naturally produced long-chain fatty acids can replace some petroleum analogs, medium-chain fatty acid would more closely match the desired physical and chemical properties of currently
Sara Huerta-Yepez et al.
International journal of oncology, 45(3), 1184-1192 (2014-06-28)
Multiple myeloma (MM) patients initially respond to conventional therapy, however, many develop resistance and have recurrences. We have reported in other tumors that the transcription factor Yin Yang 1 (YY1) is a resistant factor and, thus, we hypothesized that YY1
Simona Pisanti et al.
Journal of cellular physiology, 230(12), 2905-2914 (2015-02-17)
The endocannabinoid system, through cannabinoid receptor signaling by endocannabinoids, is involved in a wide range of functions and physiopathological conditions. To date, very little is known concerning the role of the endocannabinoids in the control and regulation of cell proliferation.
Slavyana Ivanova et al.
International journal of molecular sciences, 16(9), 21813-21831 (2015-09-16)
Squalene (SQ) possesses a wide range of pharmacological activities (antioxidant, drug carrier, detoxifier, hydrating, emollient) that can be of benefit to the ocular surface. It can come in contact with human meibum (hMGS; the most abundant component of the tear
U Taschler et al.
British journal of pharmacology, 172(17), 4419-4429 (2015-06-16)
Monoglyceride lipase (MGL) degrades 2-arachidonoyl glycerol (2-AG), an endogenous agonist of cannabinoid receptors (CB1/2 ). Because the CB1 receptor is involved in the control of gut function, we investigated the effects of pharmacological inhibition and genetic deletion of MGL on
Sunil A Sheth et al.
PloS one, 10(6), e0129735-e0129735 (2015-06-16)
Prior efforts to identify a blood biomarker of brain injury have relied almost exclusively on proteins; however their low levels at early time points and poor correlation with injury severity have been limiting. Lipids, on the other hand, are the
Breeana G Anderson et al.
Biochemistry, 53(26), 4302-4315 (2014-06-20)
Type IB topoisomerases unwind positive and negative DNA supercoils and play a key role in removing supercoils that would otherwise accumulate at replication and transcription forks. An interesting question is whether topoisomerase activity is regulated by the topological state of
C Lisa Kurtz et al.
Scientific reports, 5, 12911-12911 (2015-08-08)
MicroRNAs (miRNAs) are important regulators and potential therapeutic targets of metabolic disease. In this study we show by in vivo administration of locked nucleic acid (LNA) inhibitors that suppression of endogenous miR-29 lowers plasma cholesterol levels by ~40%, commensurate with
Megan M Maurer et al.
Food chemistry, 165, 475-482 (2014-07-21)
Carotenoid identification and quantitation is critical for the development of improved nutrition plant varieties. Industrial analysis of carotenoids is typically carried out on multiple crops with potentially thousands of samples per crop, placing critical needs on speed and broad utility
Jun Cheng et al.
Bioresource technology, 191, 66-72 (2015-05-20)
Instant catapult steam explosion (ICSE) was employed to disrupt wet microalgal cells for efficient lipid extraction. Physicochemical properties of exploded cells were investigated through SEM, TEM, FTIR, and TGA. The exploded cells increased in fractal dimension (1.53-1.65) when preheat time
Cholesterol-rich lipid rafts play an important role in the Cyprinid herpesvirus 3 replication cycle.
Graham Brogden et al.
Veterinary microbiology, 179(3-4), 204-212 (2015-06-11)
The Cyprinus herpesvirus 3 (CyHV-3) is a member of the new Alloherpesviridae virus family in the Herpesvirales order. CyHV-3 has been implicated in a large number of disease outbreaks in carp populations causing up to 100% mortality. The aim of
Sabina Sangaletti et al.
Cancer research, 74(17), 4706-4719 (2014-07-19)
The matricellular protein osteopontin (OPN, Spp-1) is widely associated with cancer aggressiveness when produced by tumor cells, but its impact is uncertain when produced by leukocytes in the context of the tumor stroma. In a broad study using Spp1(-/-) mice
Kathy Zhang et al.
mAbs, 7(1), 42-52 (2014-12-09)
Antibody-targeted nanoparticles have the potential to significantly increase the therapeutic index of cytotoxic anti-cancer therapies by directing them to tumor cells. Using antibodies or their fragments requires careful engineering because multiple parameters, including affinity, internalization rate and stability, all need
Eva Vavříková et al.
International journal of molecular sciences, 16(6), 11983-11995 (2015-05-29)
A panel of lipases was screened for the selective acetylation and alcoholysis of silychristin and silychristin peracetate, respectively. Acetylation at primary alcoholic group (C-22) of silychristin was accomplished by lipase PS (Pseudomonas cepacia) immobilized on diatomite using vinyl acetate as
Sophie M Fröhlich et al.
The Analyst, 140(17), 6089-6099 (2015-07-23)
Cardiovascular diseases present amongst the highest mortality risks in Western civilization and are frequently caused by arteriosclerotic vessel failure. Coronary artery and peripheral vessel reconstruction necessitates the use of small diameter systems that are mechanically stress-resistant and biocompatible. Expanded polytetrafluorethylene
Kyung-Mi Joo et al.
Talanta, 137, 109-119 (2015-03-17)
A rapid, sensitive, accurate and specific ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) method for the detection of N-nitrosodiethanolamine (NDELA), a highly toxic contaminant in cosmetic raw materials and products was developed and validated. Systematized sample preparation steps
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