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Xin Deng et al.
European journal of medicinal chemistry, 89, 540-548 (2014-12-03)
Chemotherapy is an important approach used to treat cancer, but severe side effects and emerging drug resistance restrict its clinical application. In this present study, we found that peptide B1 showed specific cytotoxicity to tumor cells. Moreover, a helix-wheel plot
Tao Yin et al.
PloS one, 9(12), e114581-e114581 (2014-12-19)
According to the cancer stem cells (CSCs) theory, malignant tumors may be heterogeneous in which a small population of CSCs drive the progression of cancer. Because of their intrinsic abilities, CSCs may survive a variety of treatments and then lead
Kristin Zscharnack et al.
Analytica chimica acta, 854, 145-152 (2014-12-07)
H2O2 is a widely occurring molecule which is also a byproduct of a number of enzymatic reactions. It can therefore be used to quantify the corresponding enzymatic substrates. In this study, the time-resolved fluorescence emission of a previously described complex
Viswanath Das et al.
Journal of neuroscience research, 92(9), 1155-1166 (2014-05-03)
An important aspect of synaptic plasticity in the brain is axonal transport of essential components such as mitochondria from the soma to the synapse. For uninterrupted transport of cellular cargo down the axon, functional microtubules are required. Altered microtubule dynamics
G Mangan et al.
Acta physiologica (Oxford, England), 212(1), 75-85 (2014-05-28)
The purpose of this study was to determine whether 17β-estradiol (E2) enhances the activation, proliferation and differentiation of muscle satellite cells (SC) following eccentric exercise either via insulin-like growth factor-1 (IGF-1) or through phosphatidylinositol 3-kinase (PI3K) signalling. This study used
Line Rørbæk Olsen et al.
Analytical and bioanalytical chemistry, 407(8), 2149-2158 (2014-11-19)
Desorption electrospray ionization (DESI) mass spectrometry (MS) imaging was used to image locusts dosed with the antihistamine drug terfenadine. The study was conducted in order to elucidate a relatively high elimination rate of terfenadine from the locust hemolymph. In this
Yvette M Carter et al.
Cancer biology & therapy, 15(5), 510-515 (2014-02-14)
Neuroblastoma is a common neuroendocrine (NE) tumor that presents in early childhood, with a high incidence of malignancy and recurrence. The glycogen synthase kinase-3 (GSK-3) pathway is a potential therapeutic target, as this pathway has been shown to be crucial
Aparna Lakshmanan et al.
Thyroid : official journal of the American Thyroid Association, 24(5), 878-887 (2014-01-10)
Selectively increased radioiodine accumulation in thyroid cells by thyrotropin (TSH) allows targeted treatment of thyroid cancer. However, the extent of TSH-stimulated radioiodine accumulation in some thyroid tumors is not sufficient to confer therapeutic efficacy. Hence, it is of clinical importance
D B Bas et al.
European journal of pain (London, England), 19(2), 260-270 (2014-06-20)
Mounting evidence points to individual contributions of tumour necrosis factor-alpha (TNF) and the c-Jun N-terminal kinase (JNK) pathway to the induction and maintenance of various pain states. Here we explore the role of spinal TNF and JNK in carrageenan-induced hypersensitivity.
Jun Ren et al.
American journal of respiratory and critical care medicine, 191(6), 704-710 (2015-01-17)
Apnea of prematurity, which is prevalent among infants born at less than 34 weeks gestation, is treated with caffeine, theophylline, or aminophylline. However, not all newborns respond adequately to, or tolerate, methylxanthine administration, and thus alternative pharmacological therapies are required.
Jessian L Munoz et al.
Molecular cancer therapeutics, 13(10), 2399-2411 (2014-07-24)
Glioblastoma multiforme (GBM) commonly resists the frontline chemotherapy treatment temozolomide. The multidrug resistance gene (MDR1) and its protein, P-glycoprotein (P-gp), are associated with chemoresistance. This study investigated the mechanisms underlying MDR1-mediated resistance by GBM to temozolomide. P-gp trafficking was studied
Thomas S Lisse et al.
Molecular endocrinology (Baltimore, Md.), 28(10), 1698-1706 (2014-09-03)
Alopecia (hair loss) in vitamin D receptor (VDR)-null mice is due to absence of ligand-independent actions of the VDR that are required for initiation of postmorphogenic hair cycles. Investigations were undertaken to determine whether the VDR is required for the
Julie Ladeby Erichsen et al.
Basic & clinical pharmacology & toxicology, 116(4), 329-336 (2014-09-16)
Human neural stem cells (NSCs) from the developing embryo or the subventricular zone of the adult brain can potentially elicit brain repair after injury or disease, either via endogenous cell proliferation or by cell transplantation. Profound knowledge of the diverse
Dorota Bądziul et al.
Pharmacological reports : PR, 66(2), 292-300 (2014-06-10)
High expression of HSP27 and HSP72 in glioma cells has been closely associated with chemoresistance and decreased sensitivity to programmed cell death induction. Therefore, it is important to devise therapies that effectively target invasive cancer cells by inducing cell death.
Denis Schmidt et al.
ACS chemical biology, 10(3), 715-724 (2014-11-15)
The G protein-coupled receptors of the C-X-C subfamily form a group among the chemokine receptors whose endogenous ligands are peptides with a common Cys-X-Cys motif. The CXC chemokine receptors 3 and 4 (CXCR3, CXCR4), which are investigated in this study
Charuspong Dissaranan et al.
Cell transplantation, 23(11), 1395-1406 (2013-07-23)
Vaginal delivery is a risk factor for stress urinary incontinence (SUI). Mesenchymal stem cells (MSCs) home to injured organs and can facilitate repair. The goal of this study was to determine if MSCs home to pelvic organs after simulated childbirth
Claudia Penna et al.
Basic research in cardiology, 109(4), 418-418 (2014-05-27)
Melusin is a muscle-specific protein which interacts with β1 integrin cytoplasmic domain and acts as chaperone protein. Its overexpression induces improved resistance to cardiac overload delaying left ventricle dilation and reducing the occurrence of heart failure. Here, we investigated possible
Hideki Sugii et al.
Bone, 66, 62-71 (2014-06-15)
Periodontal ligament (PDL) tissue plays an important role in tooth preservation by structurally maintaining the connection between the tooth root and the bone. The mechanisms involved in the healing and regeneration of damaged PDL tissue, caused by bacterial infection, caries
Flora Tolentino et al.
Journal of ethnopharmacology, 164, 89-95 (2015-02-15)
Rubus niveus Thunb. plant belongs to Rosaceae family and have been used traditionally to treat wounds, burns, inflammation, dysentery, diarrhea and for curing excessive bleeding during menstrual cycle. The present study was undertaken to investigate the in vivo genotoxicity of
Chiharu Mizuguchi et al.
Biochimica et biophysica acta, 1841(12), 1716-1724 (2014-10-05)
Human apolipoprotein E (apoE) isoforms exhibit different conformational stabilities and lipid-binding properties that give rise to altered cholesterol metabolism among the isoforms. Using Trp-substituted mutations and site- directed fluorescence labeling, we made a comprehensive comparison of the conformational organization of
Carl Jorns et al.
Cell transplantation, 23(8), 1009-1018 (2014-09-10)
Hepatocyte transplantation is an upcoming treatment for patients with metabolic liver diseases. Repeated cell infusions over 1-2 days improve clinical outcome. Isolated hepatocytes are usually cold stored in preservation solutions between repeated infusions. However, during cold storage isolated hepatocytes undergo
Boaz Arzi et al.
Stem cells and development, 24(7), 814-823 (2014-11-19)
Mesenchymal stem cells (MSCs) are a promising therapeutic option for various immune-mediated and inflammatory disorders due to their potent immunomodulatory and trophic properties. Naturally occurring diseases in large animal species may serve as surrogate animal models of human disease, as
Xiaolin Yang et al.
Pathology oncology research : POR, 20(3), 641-648 (2014-02-04)
TPX2 (targeting protein for xenopus kinesin-like protein 2), a microtubule-associated protein, plays an important role in the formation of the mitotic spindle. Abnormal expression of TPX2 in various types of malignant tumors has been reported, but less is known for
Theodore Hu et al.
Scientific reports, 4, 5810-5810 (2014-07-25)
Cancer is a leading cause of death worldwide. Because the cytotoxic effects of conventional chemotherapies often harm normal tissue cells along with cancer cells, conventional chemotherapies cause many unwanted or intolerable side effects. Thus, there is an unmet medical need
Tyler L Harris et al.
ACS chemical neuroscience, 5(8), 632-636 (2014-07-08)
Botulinum neurotoxicity is characterized by peripheral neuromuscular blockade/flaccid paralysis that can lead to respiratory failure and ultimately death. Current therapeutic options provide relief in a pre-exposure scenario, but there are no clinically approved postexposure medical countermeasures. Here, we introduce a
Tianxing Gong et al.
Journal of biomedical materials research. Part A, 102(7), 2295-2304 (2013-08-16)
Injectable bone cements have been well characterized and studied in non-load bearing bone fixation and bone screw augmentation applications. Current calcium phosphate cement or poly(methyl methacrylate) cement have drawbacks like low mechanical strength and in situ exothermic properties. This leads
Kimberly Cornish Carmony et al.
Chembiochem : a European journal of chemical biology, 16(2), 284-292 (2014-12-06)
In addition to two well-recognized proteasome subtypes-constitutive proteasomes and immunoproteasomes-mounting evidence also suggests the existence of intermediate proteasome subtypes containing unconventional mixtures of catalytic subunits. Although they appear to play unique biological roles, the lack of practical methods for detecting
Jun Liu et al.
International journal of biological macromolecules, 69, 1-4 (2014-05-17)
A neutral polysaccharide fraction (CGPP) was extracted from Gynostemma pentaphyllum by water extraction and ethanol precipitation. Gas chromatography (GC) analysis showed that the CGPP was mainly composed of mannose, glucose, arabinose, rhamnose, galactose and glucuronic acid in molar ratios of
Monica Verdoia et al.
Platelets, 25(5), 367-372 (2013-11-29)
Periprocedural myocardial infarction (PMI) represents a relatively common complication of percutaneous coronary intervention (PCI) and large interests have been focused on platelets in order to prevent such a complication. The single nucleotide polymorphism Leu33Pro of platelet glycoprotein IIIa has been
Katharina Wittmann et al.
Tissue engineering. Part A, 21(7-8), 1343-1353 (2015-01-21)
The development of vascularized and functional adipose tissue substitutes is required to improve soft tissue augmentation. In this study, vascularized adipose tissue constructs were generated using uncultured cells from the stromal-vascular fraction (SVF) of adipose tissue as an alternative cell
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