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45642

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Lynea A Murphy et al.
Toxicology and applied pharmacology, 260(2), 146-154 (2012-03-01)
Propiconazole is a mouse hepatotumorigenic fungicide designed to inhibit CYP51, a key enzyme in the biosynthesis of ergosterol in fungi and is widely used in agriculture to prevent fungal growth. Metabolomic studies in mice revealed that propiconazole increased levels of
S J Taj-Aldeen et al.
Infection, 40(6), 703-707 (2012-09-25)
Rhinosinusitis infection due to Saksenaea vasiformis is extremely rare. The present case describes a rhino-orbital infection in a 21-month-old Chadian immunocompetent male child with a 2-month history of excessive tearing from the right eye, followed by swelling of the right
Zhi-Hua Li et al.
Environmental toxicology, 28(3), 119-126 (2011-03-09)
In this study, the toxic effects of propiconazole (PCZ), a triazole fungicide present in aquatic environment, were studied in juvenile rainbow trout, Oncorhynchus mykiss, by acute toxicity test with the concentration of 5.04 mg/L (96 h LC50). Morphological indices, hematological
Jes Jessen Rasmussen et al.
Aquatic toxicology (Amsterdam, Netherlands), 118-119, 54-61 (2012-04-21)
Previously, laboratory experiments have revealed that freely diluted azole fungicides potentiate the direct toxic effect of pyrethroid insecticides on Daphnia magna. More ecologically relevant exposure scenarios where pesticides are adsorbed have not been addressed. In this study we exposed beech
Arthur W Garrison et al.
International journal of environmental research and public health, 8(8), 3453-3467 (2011-09-13)
Propiconazole is a chiral fungicide used in agriculture for control of many fungal diseases on a variety of crops. This use provides opportunities for pollution of soil and, subsequently, groundwater. The rate of loss of propiconazole from the water phase
Kevin A Thomas et al.
Environmental toxicology and chemistry, 30(3), 622-631 (2011-02-08)
Rates of pesticide degradation in aquatic ecosystems often differ between those observed within laboratory studies and field trials. Under field conditions, a number of additional processes may well have a significant role, yet are excluded from standard laboratory studies, for
Pengfei Leng et al.
Die Pharmazie, 67(6), 534-541 (2012-07-25)
According to its physical and chemical properties, the composition of difenoconazole/propiconazole microemulsion was as follows: xylene as solvent, emulsifier HSH as surfactant and methanol as cosurfactant. The optimal formulation of difenoconazole/propiconazole microemulsion was oil/SAA/water = 1/2/5 (w/w), in which the
Jon Hulvey et al.
Applied and environmental microbiology, 78(18), 6674-6682 (2012-07-17)
We investigated genetic factors that govern the reduced propiconazole sensitivity of Sclerotinia homoeocarpa field isolates collected during a 2-year field efficacy study on dollar spot disease of turf in five New England sites. These isolates displayed a >50-fold range of
HPLC method for simultaneous determination of fungicides: carbendazim, metalaxyl, folpet, and propiconazole in must and wine
Lopez F.L, et al.
Journal of Agricultural and Food Chemistry, 37(3), 684-687 (1989)
Fuxing Zhu et al.
Pest management science, 68(7), 1003-1009 (2012-02-22)
The long-term preservation of interesting phenotypes in plant pathogenic fungi allows for follow-up studies in the future. Twelve storage approaches were investigated to determine their effects on instability of propiconazole resistance for three demethylation inhibitor (DMI) fungicide-resistant and two DMI-sensitive
70th International Symposium on Molecular Spectroscopy (2004)
M Pugliese et al.
Communications in agricultural and applied biological sciences, 77(3), 75-78 (2012-01-01)
Silicon is the second most abundant element on earth's surface and its use can stimulate natural defense mechanisms in plants. The effect of silicate from scraps of photovoltaic industries against powdery mildew on zucchini (Cucurbita pepo) was evaluated under greenhouse
Chao Wang et al.
Journal of agricultural and food chemistry, 59(15), 8507-8512 (2011-06-28)
Propiconazole (PCZ) is an N-substituted triazole used as a fungicide on fruits, grains, seeds, hardwoods, and conifers. Although the triazole fungicides have shorter half-lives and lower bioaccumulation than the organochlorine pesticides, possible detrimental effects on the aquatic ecosystem and human
Yu Ri An et al.
Toxicology, 303, 94-98 (2012-11-20)
MicroRNA (miRNA) plays an important role in various diseases and in cellular and molecular responses to toxicants. In the present study, we investigated differential expression of miRNAs in response to three triazole fungicides (myclobutanil, propiconazole, and triadimefon). The human hepatoma
Jana Šťávová et al.
Analytica chimica acta, 702(2), 205-212 (2011-08-16)
Fungicides and insecticides are commonly used preservatives to protect wood products against microbiological degradations. Currently, there is a lack of analytical methods addressing the quantitative determination of a wide range of wood preserving species in wood matrices. In this study
Thomas Hartwig et al.
PloS one, 7(5), e36625-e36625 (2012-05-17)
Brassinosteroids (BRs) are steroidal hormones that play pivotal roles during plant development. In addition to the characterization of BR deficient mutants, specific BR biosynthesis inhibitors played an essential role in the elucidation of BR function in plants. However, high costs
Kunal Roy et al.
European journal of medicinal chemistry, 44(7), 2913-2922 (2009-01-09)
Twenty-eight structurally diverse cytochrome 3A4 (CYP3A4) inhibitors have been subjected to quantitative structure-activity relationship (QSAR) studies. The analyses were performed with electronic, spatial, topological, and thermodynamic descriptors calculated using Cerius 2 version 10 software. The statistical tools used were linear
Stephen Nesnow et al.
Chemico-biological interactions, 194(1), 79-89 (2011-08-26)
Propiconazole induces hepatocellular carcinomas and hepatocellular adenomas in mice and promotes liver tumors in rats. Transcriptional, proteomic, metabolomic and biochemical studies of hepatic tissues from mice treated with propiconazole under the conditions of the chronic bioassay indicated that propiconazole induced
Susan Hester et al.
Toxicological sciences : an official journal of the Society of Toxicology, 127(1), 54-65 (2012-02-16)
Conazoles are fungicides used as agricultural pesticides and pharmaceutical products. We investigated whether a common core of toxicological and transcriptional responses underlies the observed carcinogenic effects of three conazoles: cyproconazole, epoxiconazole, and propiconazole. In studies where mice were fed diets
Richard A Currie et al.
Toxicology, 321, 80-88 (2014-03-29)
Toxicogenomics (TGx) is employed frequently to investigate underlying molecular mechanisms of the compound of interest and, thus, has become an aid to mode of action determination. However, the results and interpretation of a TGx dataset are influenced by the experimental
Jet C Van De Steene et al.
Journal of the American Society for Mass Spectrometry, 19(5), 713-718 (2008-03-18)
When developing an LC-MS/MS-method matrix effects are a major issue. The effect of co-eluting compounds arising from the matrix can result in signal enhancement or suppression. During method development much attention should be paid to diminishing matrix effects as much
Sheela G Agrawal et al.
Journal of environmental quality, 40(4), 1273-1280 (2011-06-30)
Golf courses are vulnerable to phosphate (PO) and pesticide loss by infiltration of the sandy, porous grass rooting media used and through subsurface tile drainage. In this study, an effort was made to remove PO, chlorothalonil, mefenoxam, and propiconazole in
Maryline Calonne et al.
Chemosphere, 87(4), 376-383 (2012-01-14)
The increasing concentrations impact (0.02, 0.2 and 2 mg L(-1)) of a Sterol Biosynthesis Inhibitor (SBI) fungicide, propiconazole, was evaluated on development and sterol metabolism of two non-target organisms: mycorrhizal or non-mycorrhizal transformed chicory roots and the arbuscular mycorrhizal fungus
Sarah Y Skolness et al.
Toxicological sciences : an official journal of the Society of Toxicology, 132(2), 284-297 (2013-01-23)
Conazoles are designed to inhibit cytochrome P450 (CYP) 14α-demethylase, an enzyme key to fungal cell wall formation. In vertebrates, conazoles may inhibit other CYPs, potentially disrupting processes like sex steroid synthesis. Propiconazole is a current-use pesticide that is among the
Anja Coors et al.
Environmental toxicology and chemistry, 31(6), 1239-1248 (2012-04-11)
Wood preservative products are used globally to protect wood from fungal decay and insects. We investigated the aquatic toxicity of five commercial wood preservative products, the biocidal active substances and some formulation additives contained therein, as well as six generic
P A Paul et al.
Phytopathology, 101(9), 1122-1132 (2011-05-11)
The use of foliar fungicides on field corn has increased greatly over the past 5 years in the United States in an attempt to increase yields, despite limited evidence that use of the fungicides is consistently profitable. To assess the
Barbara S Shane et al.
Environmental and molecular mutagenesis, 53(1), 1-9 (2012-02-14)
Propiconazole (PPZ) is a conazole fungicide that is not mutagenic, clastogenic, or DNA damaging in standard in vitro and in vivo genetic toxicity tests for gene mutations, chromosome aberrations, DNA damage, and cell transformation. However, it was demonstrated to be
Eveline Snelders et al.
PloS one, 7(3), e31801-e31801 (2012-03-08)
Azoles play an important role in the management of Aspergillus diseases. Azole resistance is an emerging global problem in Aspergillus fumigatus, and may develop through patient therapy. In addition, an environmental route of resistance development has been suggested through exposure
Jeffrey A Ross et al.
Mutagenesis, 27(5), 541-549 (2012-04-12)
The mouse liver tumorigenic conazole fungicides triadimefon and propiconazole have previously been shown to be in vivo mouse liver mutagens in the Big Blue™ transgenic mutation assay when administered in feed at tumorigenic doses, whereas the nontumorigenic conazole myclobutanil was
Anna-Maija Nyman et al.
Ecotoxicology (London, England), 21(7), 1828-1840 (2012-05-09)
Toxicokinetic-toxicodynamic (TKTD) models quantify the time-course of internal concentration, which is defined by uptake, elimination and biotransformation (TK), and the processes which lead to the toxic effects (TD). TKTD models show potential in predicting pesticide effects in fluctuating concentrations, but
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